Protein: CBS
Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase)

Gene: CBS
Organism: Homo sapiens
Interactions: 118
UniProt ID: P35520

Gene Ontology (top 5):
GO:0001958 - endochondral ossification
GO:0001974 - blood vessel remodeling
GO:0004122 - cystathionine beta-synthase activity
GO:0004124 - cysteine synthase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

723952

CBS
Cystathionine beta-synthase

9

20

Small-scale

0.972

High

723960

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.702

High

723966

UBC9
SUMO-conjugating enzyme UBC9

4

1

Small-scale

0.694

High

278235

PIAS2
E3 SUMO-protein ligase PIAS2

3

2

High-throughput

0.667

High

723959

FXR2
RNA-binding protein FXR2

3

1

High-throughput

0.666

High

724024

ZMYM5
Zinc finger MYM-type protein 5

3

0

High-throughput

0.639

High

723975

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

1

High-throughput

0.628

High

723990

Q7KZS0
SUMO-conjugating enzyme UBC9

2

1

High-throughput

0.611

High

637338

PSA1
Proteasome subunit alpha type-1

2

0

High-throughput

0.601

High

723963

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

0

High-throughput

0.601

High

723979

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

0

High-throughput

0.586

High

723996

HID1
Protein HID1

2

0

High-throughput

0.582

High

724018

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

2

0

High-throughput

0.582

High

723985

RHGBB
Inactive Rho GTPase-activating protein 11B

2

2

High-throughput

0.571

High

723986

RHG29
Rho GTPase-activating protein 29

2

4

High-throughput

0.571

High

723970

ECHP
Peroxisomal bifunctional enzyme

2

0

High-throughput

0.571

High

724001

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

2

0

High-throughput

0.547

High

724006

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

723956

ATRX
Transcriptional regulator ATRX

1

2

High-throughput

0.541

High

723958

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

723994

HIPK1
Homeodomain-interacting protein kinase 1

1

3

High-throughput

0.541

High

724015

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

2

High-throughput

0.541

High

724026

FAF1
FAS-associated factor 1

1

1

High-throughput

0.541

High

724007

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.536

High

441909

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.518

High

641329

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.518

High

723968

SATB1
DNA-binding protein SATB1

1

0

High-throughput

0.518

High

723981

UGPA
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.518

High

723983

ZN181
Zinc finger protein 181

1

0

High-throughput

0.518

High

723997

SLF2
SMC5-SMC6 complex localization factor protein 2

1

0

High-throughput

0.518

High

724030

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.518

High

724031

CERT
Ceramide transfer protein

1

0

High-throughput

0.518

High

568566

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.515

High

159911

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.501

High

174671

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

723995

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.494

High

451200

TPM1
Tropomyosin alpha-1 chain

1

0

High-throughput

0.493

High

723961

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.493

High

259929

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

0

High-throughput

0.493

High

412056

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.493

High

716817

CTNB1
Catenin beta-1

1

0

High-throughput

0.493

High

723955

HD
Huntingtin

1

0

High-throughput

0.493

High

723980

CYH1
Cytohesin-1

1

0

High-throughput

0.493

High

724004

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

724028

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.493

High

498224

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

0

High-throughput

0.486

High

277956

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

Small-scale

0.481

High

724032

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

Small-scale

0.481

High

64666

RHG32
Rho GTPase-activating protein 32

1

4

High-throughput

0.479

High

226675

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

322255

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

475414

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

625175

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

684448

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

723953

MSX2
Homeobox protein MSX-2

1

1

High-throughput

0.479

High

723977

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

723982

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

723988

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

723989

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.479

High

723991

ZFY16
Zinc finger FYVE domain-containing protein 16

1

1

Small-scale

0.479

High

723993

GPSM1
G-protein-signaling modulator 1

1

3

Small-scale

0.479

High

723998

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.479

High

723999

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

724002

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.479

High

724003

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

724010

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

724014

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.479

High

724016

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

724017

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

724019

RHG35
Rho GTPase-activating protein 35

1

3

High-throughput

0.479

High

724025

RHG26
Rho GTPase-activating protein 26

1

4

High-throughput

0.479

High

123195

CBX4
E3 SUMO-protein ligase CBX4

1

0

Small-scale

0.460

High

724009

RANB9
Ran-binding protein 9

1

0

Small-scale

0.460

High

724021

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.460

High

724022

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.460

High

125193

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

241991

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

294454

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298213

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

326475

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

384382

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

552077

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

650507

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

719392

MERL
Merlin

1

0

High-throughput

0.458

High

723954

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

723962

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.458

High

723964

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

723965

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

723967

E2F1
Transcription factor E2F1

1

0

Small-scale

0.458

High

723969

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

723972

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

723973

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

723974

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

723976

CUL3
Cullin-3

1

0

High-throughput

0.458

High

723978

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

723984

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.458

High

723992

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

724000

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

724005

OPTN
Optineurin

1

0

High-throughput

0.458

High

724008

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

724011

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

724012

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

724020

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

724023

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

724027

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

437943

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.445

High

532405

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.445

High

723971

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

High-throughput

0.437

High

305996

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.426

High

503553

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

723987

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

724013

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

608418

GALA
Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide

1

0

High-throughput

0.268

Low

100546

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

719816

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

723957

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

724029

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024