Protein: MIS12
Protein MIS12 homolog

Gene: MIS12
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9H081

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000444 - MIS12/MIND type complex
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0000940 - outer kinetochore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1429539

DSN1
Kinetochore-associated protein DSN1 homolog

14

0

Small-scale

0.933

High

1240774

PMF1
Polyamine-modulated factor 1

12

0

Small-scale

0.932

High

1394502

NSL1
Kinetochore-associated protein NSL1 homolog

11

0

Small-scale

0.929

High

1041853

CENPC
Centromere protein C

4

1

High-throughput

0.906

High

1334221

SPC24
Kinetochore protein Spc24

9

1

Small-scale

0.754

High

1339881

KNL1
Outer kinetochore KNL1 complex subunit KNL1

8

1

Small-scale

0.750

High

853403

CBX5
Chromobox protein homolog 5

6

2

Small-scale

0.732

High

224167

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

6

1

Small-scale

0.730

High

329974

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

11

0

Small-scale

0.727

High

1429543

SPC25
Kinetochore protein Spc25

9

0

Small-scale

0.723

High

164084

NDC80
Kinetochore protein NDC80 homolog

8

0

Small-scale

0.718

High

1419588

NUF2
Kinetochore protein Nuf2

6

0

Small-scale

0.705

High

1097548

CBX3
Chromobox protein homolog 3

4

2

Small-scale

0.699

High

1014197

CBX1
Chromobox protein homolog 1

3

2

High-throughput

0.675

High

1429547

MAFF
Transcription factor MafF

4

0

High-throughput

0.670

High

251806

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

3

1

Small-scale

0.662

High

1326640

KIF2B
Kinesin-like protein KIF2B

2

0

High-throughput

0.602

High

1429537

KLC2
Kinesin light chain 2

2

0

High-throughput

0.602

High

461914

HS90A
Heat shock protein HSP 90-alpha

2

0

Small-scale

0.569

High

1429550

SGT1
Protein SGT1 homolog

2

0

Small-scale

0.569

High

117234

K7EJH0
Kinetochore protein Spc24

2

1

High-throughput

0.552

High

445256

S10A6
Protein S100-A6

1

2

High-throughput

0.536

High

682604

S100P
Protein S100-P

1

2

High-throughput

0.536

High

691414

1433T
14-3-3 protein theta

1

5

High-throughput

0.536

High

730224

1433B
14-3-3 protein beta/alpha

1

5

High-throughput

0.536

High

761865

HSP74
Heat shock 70 kDa protein 4

1

2

High-throughput

0.536

High

842859

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

High-throughput

0.536

High

966855

1433G
14-3-3 protein gamma

1

5

High-throughput

0.536

High

990710

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.536

High

1049760

1433F
14-3-3 protein eta

1

5

High-throughput

0.536

High

1400791

ATAD5
ATPase family AAA domain-containing protein 5

1

1

High-throughput

0.536

High

247163

TBCD4
TBC1 domain family member 4

1

0

High-throughput

0.513

High

388292

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

946527

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.513

High

971980

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

1278215

CLAP1
CLIP-associating protein 1

1

0

High-throughput

0.513

High

1359538

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.513

High

1367879

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

0

High-throughput

0.513

High

1397058

HSFY1
Heat shock transcription factor, Y-linked

1

0

High-throughput

0.513

High

1405848

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.513

High

1429541

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1429546

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

1429548

TPPC4
Trafficking protein particle complex subunit 4

1

0

High-throughput

0.513

High

1429549

TPPC8
Trafficking protein particle complex subunit 8

1

0

High-throughput

0.513

High

387328

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.493

High

706303

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

1429545

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

1

High-throughput

0.489

High

344998

WIZ
Protein Wiz

1

1

High-throughput

0.479

High

998788

H31
Histone H3.1

1

1

High-throughput

0.479

High

1017193

H33
Histone H3.3

1

1

High-throughput

0.479

High

1053339

Q05C46
CASC5 protein

1

1

High-throughput

0.479

High

1235077

ADNP2
Activity-dependent neuroprotector homeobox protein 2

1

4

High-throughput

0.479

High

1365230

HS105
Heat shock protein 105 kDa

1

2

High-throughput

0.479

High

1395202

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

1

High-throughput

0.479

High

1396300

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

High-throughput

0.479

High

1429538

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.479

High

1429540

ZN644
Zinc finger protein 644

1

1

High-throughput

0.479

High

1429542

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

1

High-throughput

0.479

High

387749

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

1

High-throughput

0.470

High

387891

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

High-throughput

0.470

High

173336

XPO1
Exportin-1

1

0

High-throughput

0.458

High

402796

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

537876

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

727958

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

957509

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

1066482

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.458

High

1094730

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.458

High

1094808

CAF1B
Chromatin assembly factor 1 subunit B

1

0

High-throughput

0.458

High

1129737

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.458

High

1132963

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1204391

SGO1
Shugoshin 1

1

0

High-throughput

0.458

High

1244827

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1277232

POGZ
Pogo transposable element with ZNF domain

1

0

High-throughput

0.458

High

1292970

AROS
Active regulator of SIRT1

1

0

High-throughput

0.458

High

1332178

SCAI
Protein SCAI

1

0

High-throughput

0.458

High

1384513

SKA1
SKA complex subunit 1

1

0

Small-scale

0.458

High

1418390

PCGF6
Polycomb group RING finger protein 6

1

0

High-throughput

0.458

High

1429536

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.458

High

253898

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

1104087

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.279

Low

1130022

KCTD2
BTB/POZ domain-containing protein KCTD2

1

0

High-throughput

0.279

Low

1206651

TJAP1
Tight junction-associated protein 1

1

0

High-throughput

0.279

Low

1270518

MARK2
Serine/threonine-protein kinase MARK2

1

0

High-throughput

0.279

Low

1418090

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.279

Low

1429544

RM17
Large ribosomal subunit protein bL17m

1

0

High-throughput

0.279

Low

366207

HPT
Haptoglobin

1

0

High-throughput

0.269

Low

369399

A1AT
Alpha-1-antitrypsin

1

0

High-throughput

0.269

Low

379043

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.269

Low

390953

TRFE
Serotransferrin

1

0

High-throughput

0.269

Low

49212

A0M8Q9
C1 segment protein

1

0

High-throughput

0.249

Low

1212457

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025