Protein: ACSL4
Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4)

Gene: ACSL4
Organism: Homo sapiens
Interactions: 164
UniProt ID: O60488

Gene Ontology (top 5):
GO:0001676 - long-chain fatty acid metabolic process
GO:0004467 - long-chain fatty acid-CoA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

249394

ACSL3
Fatty acid CoA ligase Acsl3

3

7

High-throughput

0.847

High

249421

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

3

2

High-throughput

0.667

High

249471

S39AC
Zinc transporter ZIP12

3

7

High-throughput

0.662

High

249518

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

3

5

High-throughput

0.662

High

240222

PRKN
E3 ubiquitin-protein ligase parkin

3

7

Small-scale

0.640

High

249486

EID3
EP300-interacting inhibitor of differentiation 3

3

0

High-throughput

0.638

High

249385

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

7

Small-scale

0.618

High

249410

NEP
Neprilysin

2

0

High-throughput

0.602

High

249442

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.602

High

249417

CFTR
Cystic fibrosis transmembrane conductance regulator

2

3

High-throughput

0.601

High

249491

TOIP2
Torsin-1A-interacting protein 2

3

0

High-throughput

0.585

High

249450

VA0D1
V-type proton ATPase subunit d 1

2

0

High-throughput

0.585

High

249402

GCR
Glucocorticoid receptor

2

6

Small-scale

0.584

High

249423

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

4

Small-scale

0.584

High

249455

RHOB
Rho-related GTP-binding protein RhoB

2

10

High-throughput

0.584

High

249509

TCPQM
T-complex protein 1 subunit theta-like 2

2

0

High-throughput

0.576

High

249392

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.561

High

249406

KPCB
Protein kinase C beta type

1

1

Small-scale

0.561

High

249490

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

2

1

High-throughput

0.558

High

249408

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.554

High

249512

HTAI2
Protein HTATIP2

1

0

Small-scale

0.549

High

249454

LCN6
Epididymal-specific lipocalin-6

2

1

High-throughput

0.549

High

249389

SH3L1
Adapter SH3BGRL

2

0

High-throughput

0.547

High

161908

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

1

High-throughput

0.536

High

182428

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.536

High

183894

S22A2
Solute carrier family 22 member 2

1

5

High-throughput

0.536

High

249400

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

4

High-throughput

0.536

High

249409

ASGR2
Asialoglycoprotein receptor 2

1

2

High-throughput

0.536

High

249412

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.536

High

249416

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

3

High-throughput

0.536

High

249426

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

5

High-throughput

0.536

High

249430

DHI1
11-beta-hydroxysteroid dehydrogenase 1

1

1

High-throughput

0.536

High

249438

OPRX
Nociceptin receptor

1

2

High-throughput

0.536

High

249439

EAA3
Excitatory amino acid transporter 3

1

5

High-throughput

0.536

High

249443

GPR12
G-protein coupled receptor 12

1

3

High-throughput

0.536

High

249469

AAAT
Neutral amino acid transporter B(0)

1

5

High-throughput

0.536

High

249482

T150A
Transmembrane protein 150A

1

1

High-throughput

0.536

High

249485

SPART
Spartin

1

5

Small-scale

0.536

High

249492

COQ8A
Atypical kinase COQ8A, mitochondrial

1

1

High-throughput

0.536

High

249503

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.536

High

249516

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

1

High-throughput

0.536

High

249523

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

249533

DSE
Dermatan-sulfate epimerase

1

0

High-throughput

0.518

High

249502

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.515

High

124993

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

190287

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

249419

NAGAB
Alpha-N-acetylgalactosaminidase

1

0

High-throughput

0.513

High

249432

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

249441

ABCG1
ATP-binding cassette sub-family G member 1

1

0

High-throughput

0.513

High

249459

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.513

High

249472

TJAP1
Tight junction-associated protein 1

1

0

High-throughput

0.513

High

249493

ACTT2
Actin-related protein T2

1

0

High-throughput

0.513

High

249497

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.513

High

249505

ORAI1
Calcium release-activated calcium channel protein 1

1

0

High-throughput

0.513

High

249513

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

1

0

High-throughput

0.513

High

249519

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

249536

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

249405

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

249427

1433T
14-3-3 protein theta

1

1

High-throughput

0.501

High

249470

NTRK3
NT-3 growth factor receptor

1

10

High-throughput

0.500

High

249429

DMB
HLA class II histocompatibility antigen, DM beta chain

1

3

High-throughput

0.489

High

249447

FOXA3
Hepatocyte nuclear factor 3-gamma

1

5

High-throughput

0.489

High

249448

FOXL2
Forkhead box protein L2

1

5

High-throughput

0.489

High

249479

FOXI2
Forkhead box protein I2

1

5

High-throughput

0.489

High

249484

S22A9
Organic anion transporter 7

1

5

High-throughput

0.489

High

249500

FOXJ1
Forkhead box protein J1

1

4

High-throughput

0.489

High

249501

TF3B
Transcription factor IIIB 90 kDa subunit

1

3

High-throughput

0.489

High

249506

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

249515

FOXQ1
Forkhead box protein Q1

1

6

High-throughput

0.489

High

249532

RSP14
Radial spoke head 14 homolog

1

1

High-throughput

0.489

High

137575

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.479

High

156746

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

214644

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

High-throughput

0.479

High

249386

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

249388

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

2

High-throughput

0.479

High

249393

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.479

High

249396

RASN
GTPase NRas

1

7

High-throughput

0.479

High

249397

RASH
GTPase HRas

1

5

High-throughput

0.479

High

249398

RASK
GTPase KRas

1

7

High-throughput

0.479

High

249401

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

249404

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

249414

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

249415

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

249420

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

249422

RAB5A
Ras-related protein Rab-5A

1

3

Small-scale

0.479

High

249431

PML
Protein PML

1

2

High-throughput

0.479

High

249445

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.479

High

249449

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

249451

RHOA
Transforming protein RhoA

1

10

High-throughput

0.479

High

249456

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

249457

TYB10
Thymosin beta-10

1

1

High-throughput

0.479

High

249458

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

Small-scale

0.479

High

249462

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

249466

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

1

High-throughput

0.479

High

249468

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

249478

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

249480

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

249483

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

4

Small-scale

0.479

High

249489

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

249496

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

2

High-throughput

0.479

High

249499

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

249507

RN185
E3 ubiquitin-protein ligase RNF185

1

1

High-throughput

0.479

High

249508

NEB2
Neurabin-2

1

1

High-throughput

0.479

High

249514

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

1

High-throughput

0.479

High

249520

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

249522

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

249525

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.479

High

249528

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.479

High

249530

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

249531

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

164194

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

249390

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

249403

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

249433

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

249435

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

249436

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

249437

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

249446

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

0

High-throughput

0.458

High

249453

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.458

High

249460

VIGLN
Vigilin

1

0

High-throughput

0.458

High

249461

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.458

High

249474

MIC10
MICOS complex subunit MIC10

1

0

Small-scale

0.458

High

249504

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.458

High

249524

ANTR1
Anthrax toxin receptor 1

1

0

Small-scale

0.458

High

249527

MTCH1
Mitochondrial carrier homolog 1

1

0

High-throughput

0.458

High

249534

SHLB1
Endophilin-B1

1

0

Small-scale

0.458

High

183993

S22A1
Solute carrier family 22 member 1

1

5

High-throughput

0.445

High

249391

S22A5
Organic cation/carnitine transporter 2

1

5

High-throughput

0.445

High

249407

HEPS
Serine protease hepsin

1

2

High-throughput

0.445

High

249413

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

249424

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

3

High-throughput

0.445

High

249444

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

5

High-throughput

0.445

High

249467

S39AE
Metal cation symporter ZIP14

1

7

High-throughput

0.445

High

249473

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

249477

S39A4
Zinc transporter ZIP4

1

7

High-throughput

0.445

High

249481

SV2B
Synaptic vesicle glycoprotein 2B

1

3

High-throughput

0.445

High

249498

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.445

High

249510

S39A3
Zinc transporter ZIP3

1

7

High-throughput

0.445

High

249517

S39A8
Metal cation symporter ZIP8

1

7

High-throughput

0.445

High

249395

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

249418

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

249428

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

249434

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

249452

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

249526

ANLN
Anillin

1

1

High-throughput

0.437

High

249387

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

249399

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

249411

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

1

0

High-throughput

0.426

High

249425

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

249464

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

249488

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

249494

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

0

High-throughput

0.426

High

249529

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

249535

FLVC1
Choline/ethanolamine transporter FLVCR1

1

0

High-throughput

0.426

High

249440

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.407

High

249475

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

249487

FXL16
F-box/LRR-repeat protein 16

1

2

High-throughput

0.407

High

249495

TB22A
TBC1 domain family member 22A

3

0

High-throughput

0.347

High

249521

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

2

0

High-throughput

0.305

High

249463

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

249465

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.279

Low

249511

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

249476

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025