Protein: PFD6
Prefoldin subunit 6 (Protein Ke2)

Gene: PFD6, PFDN6
Organism: Homo sapiens
Interactions: 166
UniProt ID: O15212

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0005737 - cytoplasm
GO:0006457 - protein folding
GO:0016272 - prefoldin complex
GO:0050821 - protein stabilization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

182190

PFD4
Prefoldin subunit 4

6

2

High-throughput

0.945

High

182102

PFD3
Prefoldin subunit 3

5

2

High-throughput

0.927

High

182201

UXT
Protein UXT

5

4

Small-scale

0.927

High

182204

PFD2
Prefoldin subunit 2

5

2

High-throughput

0.919

High

182066

RMP
Unconventional prefoldin RPB5 interactor 1

5

6

Small-scale

0.915

High

182176

PFD5
Prefoldin subunit 5

5

4

Small-scale

0.912

High

182061

PFD1
Prefoldin subunit 1

4

1

High-throughput

0.892

High

182191

PDRG1
p53 and DNA damage-regulated protein 1

3

1

High-throughput

0.847

High

182184

RPAP3
RNA polymerase II-associated protein 3

6

1

Small-scale

0.730

High

182086

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

4

2

High-throughput

0.694

High

182103

DCAF7
DDB1- and CUL4-associated factor 7

3

6

High-throughput

0.671

High

182105

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

3

2

Small-scale

0.671

High

182109

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

3

7

High-throughput

0.667

High

182174

DCAF5
DDB1- and CUL4-associated factor 5

3

7

High-throughput

0.667

High

182183

SKI8
Superkiller complex protein 8

3

6

High-throughput

0.667

High

182120

MK07
Mitogen-activated protein kinase 7

4

0

High-throughput

0.661

High

182152

TBA1A
Tubulin alpha-1A chain

3

5

High-throughput

0.643

High

182203

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

3

0

High-throughput

0.638

High

182079

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

1

High-throughput

0.628

High

182197

PIHD1
PIH1 domain-containing protein 1

3

0

Small-scale

0.628

High

180175

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

1

High-throughput

0.611

High

182195

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

4

High-throughput

0.611

High

182211

RUVB2
RuvB-like 2

2

2

High-throughput

0.611

High

182123

HDAC1
Histone deacetylase 1

2

0

High-throughput

0.602

High

182091

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.586

High

182122

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

5

High-throughput

0.584

High

182164

POC1B
POC1 centriolar protein homolog B

2

6

High-throughput

0.584

High

182175

DAA10
Dynein axonemal assembly factor 10

2

1

High-throughput

0.584

High

182058

MAGB4
Melanoma-associated antigen B4

2

0

High-throughput

0.580

High

182068

MBD3
Methyl-CpG-binding domain protein 3

2

0

High-throughput

0.580

High

182139

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.580

High

182205

FBX2
F-box only protein 2

2

0

High-throughput

0.580

High

182082

TBG1
Tubulin gamma-1 chain

2

5

High-throughput

0.571

High

182067

RPA1
DNA-directed RNA polymerase I subunit RPA1

2

3

High-throughput

0.558

High

182128

RBBP7
Histone-binding protein RBBP7

2

5

High-throughput

0.558

High

182093

CEBPG
CCAAT/enhancer-binding protein gamma

2

1

High-throughput

0.553

High

182078

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.547

High

161900

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

1

High-throughput

0.536

High

182088

GRK6
G protein-coupled receptor kinase 6

1

1

High-throughput

0.536

High

182098

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.536

High

182112

TBA1B
Tubulin alpha-1B chain

1

5

High-throughput

0.536

High

182114

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.536

High

182129

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

182133

DC4L1
DDB1- and CUL4-associated factor 4-like protein 1

1

1

High-throughput

0.536

High

182147

KSR2
Kinase suppressor of Ras 2

1

2

High-throughput

0.536

High

182153

STRAA
STE20-related kinase adapter protein alpha

1

1

High-throughput

0.536

High

182212

RUVB1
RuvB-like 1

1

2

High-throughput

0.536

High

182070

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.533

High

182121

ERCC8
DNA excision repair protein ERCC-8

2

7

Small-scale

0.533

High

182143

TBA3E
Tubulin alpha-3E chain

1

4

High-throughput

0.515

High

182200

WRP73
WD repeat-containing protein WRAP73

1

8

High-throughput

0.515

High

182062

KI21B
Kinesin-like protein KIF21B

1

0

High-throughput

0.513

High

182065

KS6A5
Ribosomal protein S6 kinase alpha-5

1

0

High-throughput

0.513

High

182125

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

182131

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

0

High-throughput

0.513

High

182155

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.513

High

182208

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.513

High

142239

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.489

High

182059

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

6

High-throughput

0.489

High

182081

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

1

High-throughput

0.489

High

182084

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

4

High-throughput

0.489

High

182106

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

High-throughput

0.489

High

156572

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

4

High-throughput

0.479

High

164979

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

3

High-throughput

0.479

High

182072

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

182076

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

182096

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

182099

ARP3
Actin-related protein 3

1

3

High-throughput

0.479

High

182100

ACTZ
Alpha-centractin

1

2

High-throughput

0.479

High

182111

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

182113

TBA4A
Tubulin alpha-4A chain

1

4

High-throughput

0.479

High

182135

DCAF6
DDB1- and CUL4-associated factor 6

1

9

High-throughput

0.479

High

182136

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

182144

SKI3
Superkiller complex protein 3

1

1

High-throughput

0.479

High

182156

FBXW8
F-box/WD repeat-containing protein 8

1

4

High-throughput

0.479

High

182158

WDTC1
WD and tetratricopeptide repeats protein 1

1

7

High-throughput

0.479

High

182160

POC1A
POC1 centriolar protein homolog A

1

7

High-throughput

0.479

High

182166

DCA11
DDB1- and CUL4-associated factor 11

1

6

High-throughput

0.479

High

182180

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

5

High-throughput

0.479

High

182213

FBW1A
F-box/WD repeat-containing protein 1A

1

2

High-throughput

0.479

High

131581

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

182069

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

182071

RASK
GTPase KRas

1

0

High-throughput

0.458

High

182073

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

182087

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

182090

RGS6
Regulator of G-protein signaling 6

1

0

High-throughput

0.458

High

182097

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

182110

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.458

High

182115

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High

182116

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

182124

CUL3
Cullin-3

1

0

High-throughput

0.458

High

182127

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

182149

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

182151

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

182168

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

182169

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.458

High

182170

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.458

High

182177

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

0

High-throughput

0.458

High

182178

DUS9
Dual specificity protein phosphatase 9

1

0

High-throughput

0.458

High

182185

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

182202

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

182107

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

High-throughput

0.445

High

182137

DCAF8
DDB1- and CUL4-associated factor 8

1

8

High-throughput

0.445

High

182063

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

1

High-throughput

0.437

High

182074

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

182104

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.437

High

182117

TLE2
Transducin-like enhancer protein 2

1

6

High-throughput

0.437

High

182118

RON
Macrophage-stimulating protein receptor

1

1

High-throughput

0.437

High

182126

SKI2
Superkiller complex protein 2

1

1

High-throughput

0.437

High

182142

CDC73
Parafibromin

1

1

High-throughput

0.437

High

182145

TTC33
Tetratricopeptide repeat protein 33

1

1

High-throughput

0.437

High

182146

WDR82
WD repeat-containing protein 82

1

7

High-throughput

0.437

High

182154

WDR53
WD repeat-containing protein 53

1

6

High-throughput

0.437

High

182161

NUP43
Nucleoporin Nup43

1

8

High-throughput

0.437

High

182162

COP1
E3 ubiquitin-protein ligase COP1

1

7

High-throughput

0.437

High

182167

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

182172

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.437

High

182179

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.437

High

182186

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

4

High-throughput

0.437

High

182192

DCA13
DDB1- and CUL4-associated factor 13

1

4

High-throughput

0.437

High

182198

WSB2
WD repeat and SOCS box-containing protein 2

1

6

High-throughput

0.437

High

182199

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

1

High-throughput

0.437

High

182206

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.437

High

182207

ALK
ALK tyrosine kinase receptor

1

1

High-throughput

0.437

High

182209

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.437

High

182210

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.437

High

182214

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.437

High

117722

ASURF
ASNSD1 upstream open reading frame protein

1

0

High-throughput

0.426

High

182095

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

182138

DC122
DDB1- and CUL4-associated factor 12-like protein 2

1

1

High-throughput

0.407

High

182089

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

182194

RPC5
DNA-directed RNA polymerase III subunit RPC5

2

0

High-throughput

0.318

High

182119

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

2

0

High-throughput

0.316

High

182165

CCHCR
Coiled-coil alpha-helical rod protein 1

2

0

High-throughput

0.316

High

182181

KIFC3
Kinesin-like protein KIFC3

2

0

High-throughput

0.316

High

182189

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

0

High-throughput

0.316

High

182157

ARG39
Rho guanine nucleotide exchange factor 39

2

0

High-throughput

0.298

High

182060

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.282

High

182092

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.279

Low

182094

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.279

Low

182132

PCGF3
Polycomb group RING finger protein 3

1

0

High-throughput

0.279

Low

182134

KR133
Keratin-associated protein 13-3

1

0

High-throughput

0.279

Low

182150

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.279

Low

182159

DB123
Beta-defensin 123

1

0

High-throughput

0.279

Low

182163

UHMK1
Serine/threonine-protein kinase Kist

1

0

High-throughput

0.279

Low

182080

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

182173

THA11
THAP domain-containing protein 11

1

0

Small-scale

0.265

Low

182057

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.249

Low

182064

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.249

Low

182075

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.249

Low

182083

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

182085

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

182101

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low

182108

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.249

Low

182130

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

0

High-throughput

0.249

Low

182140

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

182141

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

182182

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.249

Low

182187

RC3H2
Roquin-2

1

0

High-throughput

0.249

Low

182193

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.249

Low

182196

ASND1
Asparagine synthetase domain-containing protein 1

1

0

High-throughput

0.249

Low

182215

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.249

Low

182077

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low

182148

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low

182171

ESPB1
Epididymal sperm-binding protein 1

1

0

High-throughput

0.232

Low

182188

RAB18
Ras-related protein Rab-18

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025