Protein: PLSI
Plastin-1 (Intestine-specific plastin) (I-plastin)

Gene: PLSI, PLS1
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q14651

Gene Ontology (top 5):
GO:0001951 - intestinal D-glucose absorption
GO:0005200 - structural constituent of cytoskeleton
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568239

PLST
Plastin-3

4

17

High-throughput

0.895

High

568147

PLSL
Plastin-2

3

15

High-throughput

0.861

High

1129076

PDIA6
Protein disulfide-isomerase A6

3

6

High-throughput

0.861

High

683457

IKBA
NF-kappa-B inhibitor alpha

2

20

High-throughput

0.811

High

1129119

FSD1
Fibronectin type III and SPRY domain-containing protein 1

2

13

High-throughput

0.811

High

1119662

CDK13
Cyclin-dependent kinase 13

2

16

High-throughput

0.789

High

772803

MYH9
Myosin-9

1

15

High-throughput

0.691

High

908323

GUC2F
Retinal guanylyl cyclase 2

1

8

High-throughput

0.691

High

946410

MTPN
Myotrophin

1

20

High-throughput

0.691

High

1129118

EFC4B
EF-hand calcium-binding domain-containing protein 4B

1

4

High-throughput

0.691

High

553400

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

3

4

High-throughput

0.667

High

636852

GSTM3
Glutathione S-transferase Mu 3

3

3

High-throughput

0.667

High

787645

SPB5
Serpin B5

3

4

High-throughput

0.667

High

1129131

SPG21
Maspardin

1

0

High-throughput

0.656

High

954470

PRPS1
Ribose-phosphate pyrophosphokinase 1

3

0

High-throughput

0.638

High

1129101

METL6
tRNA N(3)-cytidine methyltransferase METTL6

3

0

High-throughput

0.638

High

1129108

NKD2
Protein naked cuticle homolog 2

3

0

High-throughput

0.638

High

1129112

DDRGK
DDRGK domain-containing protein 1

3

0

High-throughput

0.638

High

1129115

UIF
UAP56-interacting factor

3

0

High-throughput

0.638

High

248529

O10H3
Olfactory receptor 10H3

2

1

High-throughput

0.628

High

1129113

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

11

High-throughput

0.628

High

1129134

FKBPL
FK506-binding protein-like

2

10

High-throughput

0.628

High

682032

RBTN1
Rhombotin-1

1

15

High-throughput

0.618

High

1129082

ANR39
Ankyrin repeat domain-containing protein 39

1

19

High-throughput

0.618

High

157376

CTRO
Citron Rho-interacting kinase

1

18

High-throughput

0.618

High

541488

FGFR1
Fibroblast growth factor receptor 1

1

14

High-throughput

0.618

High

715585

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

High-throughput

0.618

High

952820

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

995591

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.618

High

1129077

CDK10
Cyclin-dependent kinase 10

1

5

High-throughput

0.618

High

1129090

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1129123

S2532
Solute carrier family 25 member 32

3

4

High-throughput

0.609

High

1030292

GALK2
N-acetylgalactosamine kinase

2

0

High-throughput

0.602

High

1129110

F136A
Protein FAM136A

2

0

High-throughput

0.602

High

1129135

RCAN3
Calcipressin-3

2

0

High-throughput

0.602

High

221128

SPY2
Protein sprouty homolog 2

2

0

High-throughput

0.585

High

1129083

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.575

High

155944

SOCS3
Suppressor of cytokine signaling 3

1

16

High-throughput

0.536

High

697112

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.536

High

716556

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

3

High-throughput

0.536

High

733352

CCR1
C-C chemokine receptor type 1

1

6

High-throughput

0.536

High

915088

CAZA1
F-actin-capping protein subunit alpha-1

1

10

High-throughput

0.536

High

1127804

KRT81
Keratin, type II cuticular Hb1

1

5

High-throughput

0.536

High

1129078

K1H1
Keratin, type I cuticular Ha1

1

12

High-throughput

0.536

High

1129084

OTUD3
OTU domain-containing protein 3

1

1

High-throughput

0.536

High

1129098

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

1129130

CLIC5
Chloride intracellular channel protein 5

1

3

High-throughput

0.536

High

301053

RL1D1
Ribosomal L1 domain-containing protein 1

1

2

High-throughput

0.515

High

1081294

LMOD3
Leiomodin-3

1

3

High-throughput

0.515

High

274582

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

276778

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.513

High

391698

MT2
Metallothionein-2

1

0

High-throughput

0.513

High

560969

GP1BB
Platelet glycoprotein Ib beta chain

1

0

High-throughput

0.513

High

1129079

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.513

High

1129089

IN80C
INO80 complex subunit C

1

0

High-throughput

0.513

High

1129093

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

1129094

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1129099

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.513

High

1129100

SLAI1
SLAIN motif-containing protein 1

1

0

High-throughput

0.513

High

1129102

DTD1
D-aminoacyl-tRNA deacylase 1

1

0

High-throughput

0.513

High

1129105

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

0

High-throughput

0.513

High

1129124

RM46
Large ribosomal subunit protein mL46

1

0

High-throughput

0.513

High

1129133

GSKIP
GSK3B-interacting protein

1

0

High-throughput

0.513

High

1129125

TPK1
Thiamine pyrophosphokinase 1

1

0

High-throughput

0.493

High

345180

ZMYM6
Zinc finger MYM-type protein 6

1

1

High-throughput

0.489

High

1129081

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.489

High

1129096

FA24B
Protein FAM24B

1

1

High-throughput

0.489

High

1129127

GSX1
GS homeobox 1

1

1

High-throughput

0.489

High

159653

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

15

High-throughput

0.479

High

247905

NUPR1
Nuclear protein 1

1

7

High-throughput

0.479

High

293690

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

315586

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

324866

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

425501

ISG15
Ubiquitin-like protein ISG15

1

14

High-throughput

0.479

High

507975

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.479

High

582794

EZRI
Ezrin

1

18

High-throughput

0.479

High

651328

CBL
E3 ubiquitin-protein ligase CBL

1

6

High-throughput

0.479

High

872325

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

884334

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

2

High-throughput

0.479

High

970499

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

975034

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

1114818

CUL4A
Cullin-4A

1

10

High-throughput

0.479

High

1129073

RB39A
Ras-related protein Rab-39A

1

6

High-throughput

0.479

High

1129074

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1129075

KIF14
Kinesin-like protein KIF14

1

13

High-throughput

0.479

High

1129085

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.479

High

1129087

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.479

High

1129092

KI21A
Kinesin-like protein KIF21A

1

1

High-throughput

0.479

High

1129095

RHG24
Rho GTPase-activating protein 24

1

10

High-throughput

0.479

High

1129103

NUDC2
NudC domain-containing protein 2

1

6

High-throughput

0.479

High

1129107

TP4A1
Protein tyrosine phosphatase type IVA 1

1

3

High-throughput

0.479

High

1129111

CHM4C
Charged multivesicular body protein 4c

1

20

High-throughput

0.479

High

1129114

SCLT1
Sodium channel and clathrin linker 1

1

20

High-throughput

0.479

High

1129116

RUFY1
RUN and FYVE domain-containing protein 1

1

19

High-throughput

0.479

High

1129117

LYST
Lysosomal-trafficking regulator

1

10

High-throughput

0.479

High

1129122

ACE2
Angiotensin-converting enzyme 2

1

5

High-throughput

0.479

High

1129126

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1129128

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

1129129

ANLN
Anillin

1

12

High-throughput

0.479

High

1129132

AKA7G
A-kinase anchor protein 7 isoform gamma

1

1

High-throughput

0.479

High

178779

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.458

High

716864

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

224421

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

1

High-throughput

0.445

High

827783

STAT3
Signal transducer and activator of transcription 3

1

6

High-throughput

0.445

High

1129088

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

695459

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.437

High

1129086

DCA15
DDB1- and CUL4-associated factor 15

1

2

High-throughput

0.437

High

1129106

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1029089

E2F1
Transcription factor E2F1

1

0

High-throughput

0.426

High

429891

JUN
Transcription factor Jun

1

8

High-throughput

0.407

High

1129097

ZN321
Putative protein ZNF321

1

1

High-throughput

0.407

High

664924

CRHBP
Corticotropin-releasing factor-binding protein

3

0

High-throughput

0.347

High

943673

RWD2B
RWD domain-containing protein 2B

3

0

High-throughput

0.347

High

1129121

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

3

0

High-throughput

0.347

High

1129091

CI139
Putative uncharacterized protein LINC02908

2

0

High-throughput

0.328

High

1129104

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.328

High

1129120

CNPD1
Protein CNPPD1

2

0

High-throughput

0.328

High

1129136

LIPG
Endothelial lipase

2

0

High-throughput

0.328

High

297056

DHRS3
Short-chain dehydrogenase/reductase 3

1

0

High-throughput

0.279

Low

302255

STC2
Stanniocalcin-2

1

0

High-throughput

0.279

Low

343148

CXL14
C-X-C motif chemokine 14

1

0

High-throughput

0.279

Low

1129080

CART

1

0

High-throughput

0.279

Low

1129109

BORC7
BLOC-1-related complex subunit 7

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025