Protein: INT12
Integrator complex subunit 12 (Int12) (PHD finger protein 22)

Gene: INT12, INTS12
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q96CB8

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008270 - zinc ion binding
GO:0016180 - snRNA processing
GO:0032039 - integrator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994330

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

4

1

Small-scale

0.699

High

1323824

INT1
Integrator complex subunit 1

4

1

High-throughput

0.683

High

1100949

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.656

High

998658

H31
Histone H3.1

1

1

High-throughput

0.618

High

1017096

H33
Histone H3.3

1

1

High-throughput

0.618

High

906139

AL3A2
Aldehyde dehydrogenase family 3 member A2

3

1

High-throughput

0.609

High

717930

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

0

High-throughput

0.602

High

775248

FUS
RNA-binding protein FUS

1

0

High-throughput

0.586

High

1141253

BRD3
Bromodomain-containing protein 3

1

0

High-throughput

0.586

High

130570

SPT5H
Transcription elongation factor SPT5

2

0

High-throughput

0.585

High

1135770

HAPR1
HUWE1-associated protein modifying stress responses 1

2

0

High-throughput

0.580

High

665324

EDNRB
Endothelin receptor type B

2

2

High-throughput

0.574

High

771198

APJ
Apelin receptor

2

3

High-throughput

0.574

High

936103

PAR2
Proteinase-activated receptor 2

2

6

High-throughput

0.574

High

396675

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1385767

INT6
Integrator complex subunit 6

2

0

Small-scale

0.559

High

1362508

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

2

1

High-throughput

0.558

High

1385764

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

Small-scale

0.549

High

182715

GP182
G-protein coupled receptor 182

2

5

High-throughput

0.549

High

956971

CXCR4
C-X-C chemokine receptor type 4

2

6

High-throughput

0.549

High

1101620

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

6

High-throughput

0.549

High

977559

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

1

High-throughput

0.536

High

1385743

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

High-throughput

0.536

High

1385745

INT14
Integrator complex subunit 14

1

1

High-throughput

0.536

High

208876

ZBT24
Zinc finger and BTB domain-containing protein 24

1

0

High-throughput

0.513

High

542156

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

601975

ZNF8
Zinc finger protein 8

1

0

High-throughput

0.513

High

603676

JUNB
Transcription factor JunB

1

0

High-throughput

0.513

High

621707

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.513

High

621932

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

723042

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

787768

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

912211

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.513

High

923520

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

959021

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

997927

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.513

High

1042771

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

0

High-throughput

0.513

High

1065352

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1152379

ZN174
Zinc finger protein 174

1

0

High-throughput

0.513

High

1295283

P66A
Transcriptional repressor p66-alpha

1

0

High-throughput

0.513

High

1357361

NAT14
Probable N-acetyltransferase 14

1

0

High-throughput

0.513

High

1385749

NELFA
Negative elongation factor A

1

0

High-throughput

0.513

High

1385761

FOXJ2
Forkhead box protein J2

1

0

High-throughput

0.513

High

1385768

FZD10
Frizzled-10

1

0

High-throughput

0.513

High

887100

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.505

High

210416

MTLR
Motilin receptor

1

3

High-throughput

0.489

High

406920

MAS
Proto-oncogene Mas

1

6

High-throughput

0.489

High

587358

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

1

1

High-throughput

0.489

High

719827

V2R
Vasopressin V2 receptor

1

1

High-throughput

0.489

High

833852

P2RY2
P2Y purinoceptor 2

1

5

High-throughput

0.489

High

143180

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

474195

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

520269

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

1087933

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

1124389

ELOA1
Elongin-A

1

1

Small-scale

0.479

High

1133594

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

1314960

ELOA2
Elongin-A2

1

1

High-throughput

0.479

High

1351118

SP7
Transcription factor Sp7

1

1

High-throughput

0.479

High

1366983

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1385763

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

218606

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

242532

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

558319

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

589366

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

675619

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

696165

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768848

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

980114

H4
Histone H4

1

0

High-throughput

0.458

High

1141851

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

1198197

PDCD4
Programmed cell death protein 4

1

0

High-throughput

0.458

High

1212127

OTUD3
OTU domain-containing protein 3

1

0

High-throughput

0.458

High

1229186

INT3
Integrator complex subunit 3

1

0

High-throughput

0.458

High

1243321

INT5
Integrator complex subunit 5

1

0

High-throughput

0.458

High

1276616

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1287000

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

0

Small-scale

0.458

High

1385747

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1385748

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.458

High

1385752

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

1385757

INT10
Integrator complex subunit 10

1

0

Small-scale

0.458

High

1385760

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

541048

PIM1
Serine/threonine-protein kinase pim-1

1

0

High-throughput

0.426

High

869511

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

High-throughput

0.426

High

954726

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

1111177

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1130377

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1335883

RN169
E3 ubiquitin-protein ligase RNF169

1

0

Small-scale

0.426

High

638491

FPR1
fMet-Leu-Phe receptor

1

5

High-throughput

0.407

High

669350

ACKR3
Atypical chemokine receptor 3

1

5

High-throughput

0.407

High

722803

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

1

High-throughput

0.407

High

886117

CXCR3
C-X-C chemokine receptor type 3

1

4

High-throughput

0.407

High

1291856

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

5

High-throughput

0.407

High

1385759

TA2R7
Taste receptor type 2 member 7

3

0

High-throughput

0.347

High

50652

HACL2
2-hydroxyacyl-CoA lyase 2

3

0

High-throughput

0.345

High

1128937

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

1204606

AR13A
ADP-ribosylation factor-like protein 13A

2

0

High-throughput

0.328

High

850902

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

2

0

High-throughput

0.318

High

1317037

FAM9A
Protein FAM9A

2

0

High-throughput

0.316

High

1385758

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.313

High

225380

ERD23
ER lumen protein-retaining receptor 3

1

0

High-throughput

0.279

Low

289366

CTAG2
Cancer/testis antigen 2

1

0

High-throughput

0.279

Low

303691

JTB
Protein JTB

1

0

High-throughput

0.279

Low

627907

TCO2
Transcobalamin-2

1

0

High-throughput

0.279

Low

847789

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.279

Low

914321

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

1234703

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.279

Low

1281713

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

0

High-throughput

0.279

Low

1291651

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1313633

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

1

0

High-throughput

0.279

Low

1329466

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

1350853

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1385754

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

0

High-throughput

0.279

Low

1385756

LIN7C
Protein lin-7 homolog C

1

0

High-throughput

0.279

Low

1385762

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.279

Low

1385765

CTNA3
Catenin alpha-3

1

0

High-throughput

0.279

Low

1385766

DKKL1
Dickkopf-like protein 1

1

0

High-throughput

0.279

Low

229783

CALU
Calumenin

1

0

High-throughput

0.269

Low

422838

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

774547

BASI
Basigin

1

0

High-throughput

0.249

Low

1049650

1433F
14-3-3 protein eta

1

0

High-throughput

0.249

Low

1101297

SLAF1
Signaling lymphocytic activation molecule

1

0

High-throughput

0.249

Low

1241925

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1256919

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

1385750

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

166385

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.232

Low

704056

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.232

Low

1385744

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.232

Low

1385746

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.232

Low

1385751

ZDH11
Palmitoyltransferase ZDHHC11

1

0

High-throughput

0.232

Low

1385753

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.232

Low

1385755

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low

1385769

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025