Protein: SGO1
Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1)

Gene: SGO1
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q5FBB7

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0000776 - kinetochore
GO:0000779 - condensed chromosome, centromeric region
GO:0000922 - spindle pole
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994249

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

8

1

Small-scale

0.753

High

977513

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

5

1

High-throughput

0.716

High

717841

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

4

1

High-throughput

0.699

High

853289

CBX5
Chromobox protein homolog 5

4

2

Small-scale

0.698

High

1143885

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

4

4

Small-scale

0.686

High

1131667

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

4

4

Small-scale

0.679

High

1014119

CBX1
Chromobox protein homolog 1

3

2

Small-scale

0.661

High

1103127

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

3

4

Small-scale

0.650

High

238536

RAD21
Double-strand-break repair protein rad21 homolog

3

0

Small-scale

0.638

High

1204372

STAG2
Cohesin subunit SA-2

3

0

Small-scale

0.638

High

1097327

CBX3
Chromobox protein homolog 3

2

2

Small-scale

0.606

High

275897

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

2

1

High-throughput

0.601

High

317182

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

2

2

High-throughput

0.601

High

718131

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

2

1

High-throughput

0.601

High

1029309

SET
Protein SET

2

1

High-throughput

0.601

High

1143925

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

2

4

High-throughput

0.601

High

1158051

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

2

4

High-throughput

0.601

High

342904

HERC2
E3 ubiquitin-protein ligase HERC2

2

0

High-throughput

0.576

High

1204376

WDR48
WD repeat-containing protein 48

2

0

High-throughput

0.576

High

1204377

WDR20
WD repeat-containing protein 20

2

0

High-throughput

0.576

High

1130066

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

Small-scale

0.571

High

1177566

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

Small-scale

0.554

High

1144567

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.537

High

967152

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

1

High-throughput

0.536

High

1204383

CDCA5
Sororin

1

0

Small-scale

0.530

High

1200121

BOREA
Borealin

1

0

Small-scale

0.518

High

278365

NCOR1
Nuclear receptor corepressor 1

1

0

High-throughput

0.513

High

722718

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

High-throughput

0.513

High

870135

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

0

High-throughput

0.513

High

922220

CATC
Dipeptidyl peptidase 1

1

0

High-throughput

0.513

High

944814

PCBP3
Poly(rC)-binding protein 3

1

0

High-throughput

0.513

High

1055921

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.513

High

1092555

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.513

High

1204364

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.513

High

1204366

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.513

High

1204369

WAPL
Wings apart-like protein homolog

1

0

Small-scale

0.513

High

1204370

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

0

High-throughput

0.513

High

1204371

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.513

High

1204374

PAF1
RNA polymerase II-associated factor 1 homolog

1

0

High-throughput

0.513

High

1204379

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.513

High

1204381

KAT6B
Histone acetyltransferase KAT6B

1

0

High-throughput

0.513

High

1204389

KIF2C
Kinesin-like protein KIF2C

1

0

High-throughput

0.513

High

1204390

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

0

High-throughput

0.513

High

1204395

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.513

High

1204398

RNC
Ribonuclease 3

1

0

High-throughput

0.513

High

1204401

DNM3B
DNA

1

0

High-throughput

0.513

High

1204402

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.513

High

1204403

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.513

High

1204404

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.513

High

1204405

CHM2B
Charged multivesicular body protein 2b

1

0

High-throughput

0.513

High

1204399

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

2

Small-scale

0.500

High

982459

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.493

High

1204361

MTCL3
Microtubule cross-linking factor 3

1

1

High-throughput

0.489

High

998400

H31
Histone H3.1

1

1

High-throughput

0.479

High

1016915

H33
Histone H3.3

1

1

High-throughput

0.479

High

1147044

ELOC
Elongin-C

1

1

High-throughput

0.479

High

1204388

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

High-throughput

0.479

High

1204396

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

1

High-throughput

0.479

High

251771

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

Small-scale

0.458

High

413968

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

776967

PPM1A
Protein phosphatase 1A

1

0

Small-scale

0.458

High

920012

PLK1
Serine/threonine-protein kinase PLK1

1

0

Small-scale

0.458

High

980820

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1045366

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1094770

CAF1B
Chromatin assembly factor 1 subunit B

1

0

High-throughput

0.458

High

1124609

SRC8
Src substrate cortactin

1

0

High-throughput

0.458

High

1204360

OTUD3
OTU domain-containing protein 3

1

0

High-throughput

0.458

High

1204363

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.458

High

1204368

POGZ
Pogo transposable element with ZNF domain

1

0

High-throughput

0.458

High

1204378

CIP2A
Protein CIP2A

1

0

Small-scale

0.458

High

1204384

AURKB
Aurora kinase B

1

0

Small-scale

0.458

High

1204385

NSL1
Kinetochore-associated protein NSL1 homolog

1

0

High-throughput

0.458

High

1204386

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

0

High-throughput

0.458

High

1204391

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.458

High

1204392

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.458

High

1204397

INCE
Inner centromere protein

1

0

Small-scale

0.458

High

322837

MTCL2
Microtubule cross-linking factor 2

1

1

High-throughput

0.445

High

516015

SETLP
Protein SETSIP

1

1

High-throughput

0.445

High

1204394

ZN768
Zinc finger protein 768

1

1

High-throughput

0.437

High

1204375

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.426

High

95779

E5RHG8
Elongin-C

1

1

High-throughput

0.407

High

116330

H3BS42
Zinc finger protein 768

1

1

High-throughput

0.407

High

936557

AF17
Protein AF-17

2

0

High-throughput

0.328

High

1204387

NEUL4
Neuralized-like protein 4

2

0

High-throughput

0.313

High

297356

DYSF
Dysferlin

1

0

High-throughput

0.279

Low

706149

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

1204365

F10C1
Protein FRA10AC1

1

0

High-throughput

0.279

Low

1204373

KLH36
Kelch-like protein 36

1

0

High-throughput

0.279

Low

1204400

IMPCT
Protein IMPACT

1

0

High-throughput

0.279

Low

106060

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

948206

ZN445
Zinc finger protein 445

1

0

High-throughput

0.249

Low

1094688

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.249

Low

1204367

LRC8D
Volume-regulated anion channel subunit LRRC8D

1

0

Small-scale

0.249

Low

1204393

ZN644
Zinc finger protein 644

1

0

High-throughput

0.249

Low

47528

RPSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.232

Low

1204362

PR14L
Protein PRR14L

1

0

High-throughput

0.232

Low

1204380

ZN526
Zinc finger protein 526

1

0

High-throughput

0.232

Low

1204382

K0232
Uncharacterized protein KIAA0232

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025