Protein: HNF1B
Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1)

Gene: HNF1B
Organism: Homo sapiens
Interactions: 189
UniProt ID: P35680

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001221 - transcription coregulator binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

775818

PHS
Pterin-4-alpha-carbinolamine dehydratase

6

6

High-throughput

0.737

High

635169

HNF1A
Hepatocyte nuclear factor 1-alpha

5

13

Small-scale

0.713

High

775907

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

2

6

High-throughput

0.611

High

209957

CRX
Cone-rod homeobox protein

2

19

High-throughput

0.606

High

733237

OTX2
Homeobox protein OTX2

2

19

High-throughput

0.606

High

775815

AF10
Protein AF-10

2

5

High-throughput

0.606

High

775821

PO6F2
POU domain, class 6, transcription factor 2

2

20

High-throughput

0.606

High

775833

VAC14
Protein VAC14 homolog

2

1

High-throughput

0.606

High

775863

UFSP1
Ufm1-specific protease 1

2

2

High-throughput

0.606

High

775865

KR261
Keratin-associated protein 26-1

2

1

High-throughput

0.606

High

775800

HNF1B
Hepatocyte nuclear factor 1-beta

2

16

Small-scale

0.595

High

675387

TYY1
Transcriptional repressor protein YY1

1

9

High-throughput

0.561

High

775854

CJ055
Uncharacterized protein C10orf55

2

1

High-throughput

0.553

High

775916

BPIA1
BPI fold-containing family A member 1

2

1

High-throughput

0.553

High

775828

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

4

High-throughput

0.536

High

224945

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.501

High

226517

TLX2
T-cell leukemia homeobox protein 2

1

19

High-throughput

0.501

High

239921

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.501

High

289123

PRDM1
PR domain zinc finger protein 1

1

5

High-throughput

0.501

High

662202

PAX7
Paired box protein Pax-7

1

18

High-throughput

0.501

High

685115

PAX6
Paired box protein Pax-6

1

18

High-throughput

0.501

High

775801

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.501

High

775802

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.501

High

775809

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.501

High

775810

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.501

High

775817

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.501

High

775820

H31
Histone H3.1

1

5

Small-scale

0.501

High

775825

PAX2
Paired box protein Pax-2

1

16

High-throughput

0.501

High

775830

PAX8
Paired box protein Pax-8

1

16

High-throughput

0.501

High

775847

TBR1
T-box brain protein 1

1

12

High-throughput

0.501

High

775855

OTUD3
OTU domain-containing protein 3

1

1

Small-scale

0.501

High

775886

SP7
Transcription factor Sp7

1

4

High-throughput

0.501

High

775897

LHX4
LIM/homeobox protein Lhx4

1

12

High-throughput

0.501

High

775912

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.501

High

593037

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

Small-scale

0.481

High

617082

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

3

Small-scale

0.481

High

317443

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.479

High

131140

CLIC1
Chloride intracellular channel protein 1

1

1

High-throughput

0.479

High

138976

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

142869

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

154637

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161422

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174317

ZN609
Zinc finger protein 609

1

20

High-throughput

0.479

High

177441

ZN536
Zinc finger protein 536

1

7

High-throughput

0.479

High

180727

TIF1A
Transcription intermediary factor 1-alpha

1

15

High-throughput

0.479

High

194516

KDM6A
Lysine-specific demethylase 6A

1

10

High-throughput

0.479

High

245595

ZEB2
Zinc finger E-box-binding homeobox 2

1

13

High-throughput

0.479

High

261374

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

6

High-throughput

0.479

High

277154

ZN217
Zinc finger protein 217

1

4

High-throughput

0.479

High

278254

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

297480

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

High-throughput

0.479

High

323211

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

High-throughput

0.479

High

341531

EYA4
Protein phosphatase EYA4

1

20

High-throughput

0.479

High

344877

WIZ
Protein Wiz

1

8

High-throughput

0.479

High

376736

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

3

High-throughput

0.479

High

487023

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

505526

ATX1L
Ataxin-1-like

1

12

High-throughput

0.479

High

534716

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

554172

BMP4
Bone morphogenetic protein 4

1

3

High-throughput

0.479

High

557903

XRCC6
X-ray repair cross-complementing protein 6

1

7

High-throughput

0.479

High

559732

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

586237

ZEP1
Zinc finger protein 40

1

12

High-throughput

0.479

High

588058

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

643424

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

High-throughput

0.479

High

764486

CTNB1
Catenin beta-1

1

3

High-throughput

0.479

High

775803

ZEB1
Zinc finger E-box-binding homeobox 1

1

7

High-throughput

0.479

High

775804

IF4A3
Eukaryotic initiation factor 4A-III

1

4

High-throughput

0.479

High

775805

CUX1
Homeobox protein cut-like 1

1

19

High-throughput

0.479

High

775806

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

775808

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

775812

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

High-throughput

0.479

High

775813

HIRA
Protein HIRA

1

9

High-throughput

0.479

High

775814

ATX1
Ataxin-1

1

12

High-throughput

0.479

High

775816

AF17
Protein AF-17

1

4

High-throughput

0.479

High

775819

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.479

High

775822

FOXK2
Forkhead box protein K2

1

18

High-throughput

0.479

High

775823

SATB1
DNA-binding protein SATB1

1

9

High-throughput

0.479

High

775824

EWS
RNA-binding protein EWS

1

8

High-throughput

0.479

High

775826

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

775827

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

775829

RING1
E3 ubiquitin-protein ligase RING1

1

15

High-throughput

0.479

High

775832

TLE5
TLE family member 5

1

20

High-throughput

0.479

High

775834

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

775835

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.479

High

775836

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

775837

FOXC1
Forkhead box protein C1

1

18

High-throughput

0.479

High

775838

GPS2
G protein pathway suppressor 2

1

4

High-throughput

0.479

High

775839

TCOF
Treacle protein

1

18

High-throughput

0.479

High

775840

GSE1
Genetic suppressor element 1

1

4

High-throughput

0.479

High

775841

MEF2D
Myocyte-specific enhancer factor 2D

1

4

High-throughput

0.479

High

775842

ARI5B
AT-rich interactive domain-containing protein 5B

1

20

High-throughput

0.479

High

775843

RBBP5
Retinoblastoma-binding protein 5

1

9

High-throughput

0.479

High

775844

PCBP1
Poly(rC)-binding protein 1

1

3

High-throughput

0.479

High

775845

NCOA2
Nuclear receptor coactivator 2

1

20

High-throughput

0.479

High

775846

ZFHX3
Zinc finger homeobox protein 3

1

13

High-throughput

0.479

High

775849

ZN260
Zinc finger protein 260

1

2

High-throughput

0.479

High

775850

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

775851

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

10

High-throughput

0.479

High

775853

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

6

High-throughput

0.479

High

775856

LIN9
Protein lin-9 homolog

1

2

High-throughput

0.479

High

775857

ZMYM4
Zinc finger MYM-type protein 4

1

8

High-throughput

0.479

High

775858

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

775859

NIPBL
Nipped-B-like protein

1

11

High-throughput

0.479

High

775860

LIN54
Protein lin-54 homolog

1

1

High-throughput

0.479

High

775861

TET2
Methylcytosine dioxygenase TET2

1

1

High-throughput

0.479

High

775862

HMBX1
Homeobox-containing protein 1

1

15

High-throughput

0.479

High

775864

NFRKB
Nuclear factor related to kappa-B-binding protein

1

17

High-throughput

0.479

High

775866

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

10

High-throughput

0.479

High

775867

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

12

High-throughput

0.479

High

775868

MCAF1
Activating transcription factor 7-interacting protein 1

1

20

High-throughput

0.479

High

775869

BCOR
BCL-6 corepressor

1

10

High-throughput

0.479

High

775870

UBN2
Ubinuclein-2

1

20

High-throughput

0.479

High

775871

PAXI1
PAX-interacting protein 1

1

20

High-throughput

0.479

High

775873

ASXL2
Putative Polycomb group protein ASXL2

1

17

High-throughput

0.479

High

775874

POGZ
Pogo transposable element with ZNF domain

1

5

High-throughput

0.479

High

775875

LDB1
LIM domain-binding protein 1

1

7

High-throughput

0.479

High

775876

PB1
Protein polybromo-1

1

16

High-throughput

0.479

High

775877

ZFHX4
Zinc finger homeobox protein 4

1

12

High-throughput

0.479

High

775879

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

775880

MGAP
MAX gene-associated protein

1

13

High-throughput

0.479

High

775881

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.479

High

775882

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

775883

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

775884

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

775885

KDM2B
Lysine-specific demethylase 2B

1

9

High-throughput

0.479

High

775888

MORC4
MORC family CW-type zinc finger protein 4

1

5

High-throughput

0.479

High

775889

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

775890

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

10

High-throughput

0.479

High

775891

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

775892

MAML1
Mastermind-like protein 1

1

20

High-throughput

0.479

High

775893

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

775894

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

775895

CBP
CREB-binding protein

1

20

High-throughput

0.479

High

775896

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

775898

MBD6
Methyl-CpG-binding domain protein 6

1

16

High-throughput

0.479

High

775899

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

12

High-throughput

0.479

High

775900

EP400
E1A-binding protein p400

1

18

High-throughput

0.479

High

775901

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

775902

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

775903

PCGF1
Polycomb group RING finger protein 1

1

15

High-throughput

0.479

High

775904

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

1

High-throughput

0.479

High

775905

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

1

High-throughput

0.479

High

775906

SP130
Histone deacetylase complex subunit SAP130

1

20

High-throughput

0.479

High

775908

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

5

High-throughput

0.479

High

775909

ING2
Inhibitor of growth protein 2

1

9

High-throughput

0.479

High

775911

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

775913

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

6

High-throughput

0.479

High

775914

BRMS1
Breast cancer metastasis-suppressor 1

1

6

High-throughput

0.479

High

775915

SHCAF
SIN3-HDAC complex-associated factor

1

2

High-throughput

0.479

High

775917

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

775918

UBN1
Ubinuclein-1

1

11

High-throughput

0.479

High

775919

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

775920

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.479

High

775921

ING3
Inhibitor of growth protein 3

1

5

High-throughput

0.479

High

775922

BCLF1
Bcl-2-associated transcription factor 1

1

4

High-throughput

0.479

High

775923

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

20

High-throughput

0.479

High

775924

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

20

High-throughput

0.479

High

775925

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

14

High-throughput

0.479

High

775926

TRPS1
Zinc finger transcription factor Trps1

1

11

High-throughput

0.479

High

775927

DACH1
Dachshund homolog 1

1

3

High-throughput

0.479

High

775928

SIX4
Homeobox protein SIX4

1

20

High-throughput

0.479

High

775929

ING1
Inhibitor of growth protein 1

1

10

High-throughput

0.479

High

775930

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

775931

ZN608
Zinc finger protein 608

1

11

High-throughput

0.479

High

775932

PRR12
Proline-rich protein 12

1

20

High-throughput

0.479

High

775933

SOX13
Transcription factor SOX-13

1

20

High-throughput

0.479

High

775934

SATB2
DNA-binding protein SATB2

1

9

High-throughput

0.479

High

775935

RUVB2
RuvB-like 2

1

1

High-throughput

0.479

High

775937

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

775939

TR150
Thyroid hormone receptor-associated protein 3

1

5

High-throughput

0.479

High

775940

ZN281
Zinc finger protein 281

1

6

High-throughput

0.479

High

775941

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

775942

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

775943

CABIN
Calcineurin-binding protein cabin-1

1

18

High-throughput

0.479

High

775944

NCOA3
Nuclear receptor coactivator 3

1

20

High-throughput

0.479

High

611786

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

612526

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

775807

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

775811

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.458

High

775831

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.458

High

775910

EPC1
Enhancer of polycomb homolog 1

1

0

High-throughput

0.458

High

775936

POLH
DNA polymerase eta

1

0

High-throughput

0.458

High

775938

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

775848

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

775852

PRC2B
Protein PRRC2B

1

20

High-throughput

0.437

High

775878

PRSR1
Proline and serine-rich protein 1

1

19

High-throughput

0.437

High

775872

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

775887

OXER1
Oxoeicosanoid receptor 1

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025