Protein: GRAM4
GRAM domain-containing protein 4 (Death-inducing protein)

Gene: GRAM4, GRAMD4
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q6IC98

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005789 - endoplasmic reticulum membrane
GO:0006915 - apoptotic process
GO:0031966 - mitochondrial membrane
GO:0034164 - negative regulation of toll-like receptor 9 signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1233846

MTMR9
Myotubularin-related protein 9

2

0

High-throughput

0.655

High

332159

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

2

0

High-throughput

0.580

High

951208

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

1233851

PKHF2
Pleckstrin homology domain-containing family F member 2

2

1

High-throughput

0.553

High

1145873

RBP1
RalA-binding protein 1

2

0

High-throughput

0.547

High

422327

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

213946

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.479

High

820671

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.479

High

1233845

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.479

High

1233855

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

Small-scale

0.479

High

74236

B2RWP4
TACC2 protein

1

1

High-throughput

0.470

High

141528

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

173955

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

417500

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.458

High

547625

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

Small-scale

0.458

High

724108

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

Small-scale

0.458

High

1040146

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

Small-scale

0.458

High

1048560

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

Small-scale

0.458

High

1233837

NOA1
Nitric oxide-associated protein 1

1

0

Small-scale

0.458

High

1233840

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1233847

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1233854

COPG2
Coatomer subunit gamma-2

1

0

Small-scale

0.458

High

334299

TACC2
Transforming acidic coiled-coil-containing protein 2

1

1

High-throughput

0.439

High

257884

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

Small-scale

0.437

High

1233838

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.426

High

1233839

TBC15
TBC1 domain family member 15

3

0

High-throughput

0.345

High

1200571

CTSRT
Cation channel sperm-associated targeting subunit tau

2

0

High-throughput

0.316

High

1233833

CC146
Coiled-coil domain-containing protein 146

2

0

High-throughput

0.316

High

1233834

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.316

High

1233835

FAM9B
Protein FAM9B

2

0

High-throughput

0.316

High

1233843

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.316

High

1233844

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.316

High

1233849

SH24A
SH2 domain-containing protein 4A

2

0

High-throughput

0.316

High

482620

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

0

High-throughput

0.279

Low

1233841

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.279

Low

1065669

RBL2
Retinoblastoma-like protein 2

1

0

Small-scale

0.251

Low

250660

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

Small-scale

0.249

Low

286218

CSDE1
Cold shock domain-containing protein E1

1

0

Small-scale

0.249

Low

293846

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

377604

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

476721

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.249

Low

521747

H14
Histone H1.4

1

0

Small-scale

0.249

Low

695712

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.249

Low

702982

DPOD1
DNA polymerase delta catalytic subunit

1

0

Small-scale

0.249

Low

832061

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

0

Small-scale

0.249

Low

838739

MTREX
Exosome RNA helicase MTR4

1

0

Small-scale

0.249

Low

894817

EMD
Emerin

1

0

High-throughput

0.249

Low

897309

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.249

Low

1009223

PRR3
Proline-rich protein 3

1

0

Small-scale

0.249

Low

1027045

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1057179

PRDX1
Peroxiredoxin-1

1

0

Small-scale

0.249

Low

1100011

TIF1B
Transcription intermediary factor 1-beta

1

0

Small-scale

0.249

Low

1102573

MTA1
Metastasis-associated protein MTA1

1

0

High-throughput

0.249

Low

1141691

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

1148700

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

Small-scale

0.249

Low

1159969

SRSF7
Serine/arginine-rich splicing factor 7

1

0

Small-scale

0.249

Low

1233831

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

Small-scale

0.249

Low

1233832

DJC10
DnaJ homolog subfamily C member 10

1

0

Small-scale

0.249

Low

1233836

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

1233842

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

Small-scale

0.249

Low

1233848

NAT10
RNA cytidine acetyltransferase

1

0

Small-scale

0.249

Low

1233850

PHAX
Phosphorylated adapter RNA export protein

1

0

Small-scale

0.249

Low

1233852

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

0

Small-scale

0.249

Low

1233853

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025