Protein: LYSC
Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)

Gene: LYSC, LYZ
Organism: Homo sapiens
Interactions: 156
UniProt ID: P61626

Gene Ontology (top 5):
GO:0003796 - lysozyme activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006954 - inflammatory response
GO:0019730 - antimicrobial humoral response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

963162

LYSC
Lysozyme C

1

2

Small-scale

0.701

High

963206

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.691

High

963181

IKBB
NF-kappa-B inhibitor beta

1

0

High-throughput

0.586

High

963192

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

0

High-throughput

0.578

High

963188

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

963205

FRMD1
FERM domain-containing protein 1

2

1

High-throughput

0.574

High

963229

DDX31
ATP-dependent DNA helicase DDX31

2

1

High-throughput

0.574

High

963225

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.569

High

411684

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.553

High

210739

KLK10
Kallikrein-10

1

2

High-throughput

0.536

High

443289

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.536

High

963176

CUL4B
Cullin-4B

1

1

High-throughput

0.536

High

695108

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.517

High

608244

EGLN
Endoglin

1

0

High-throughput

0.513

High

963183

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

963212

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

533632

CLUS
Clusterin

1

1

Small-scale

0.501

High

699450

PROP
Properdin

1

2

Small-scale

0.501

High

648127

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.493

High

893013

KHK
Ketohexokinase

1

0

High-throughput

0.493

High

67428

GOG8A
Golgin subfamily A member 8A

1

1

High-throughput

0.489

High

317157

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

High-throughput

0.489

High

689889

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

6

High-throughput

0.489

High

908247

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

1

High-throughput

0.489

High

963207

TTC13
Tetratricopeptide repeat protein 13

1

3

High-throughput

0.489

High

963213

TM131
Transmembrane protein 131

1

1

High-throughput

0.489

High

963218

TTC17
Tetratricopeptide repeat protein 17

1

2

High-throughput

0.489

High

963236

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

6

High-throughput

0.489

High

963244

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

1

High-throughput

0.489

High

391011

TRFL
Lactotransferrin

1

0

Small-scale

0.480

High

955018

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

167861

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

1

High-throughput

0.479

High

914232

EFNA4
Ephrin-A4

1

1

High-throughput

0.479

High

963180

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

963250

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

963184

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

1

High-throughput

0.470

High

127311

LEG8
Galectin-8

1

0

Small-scale

0.458

High

141398

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

345604

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

552935

PIP
Prolactin-inducible protein

1

0

High-throughput

0.458

High

558002

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

584652

HIS3
Histatin-3

1

0

Small-scale

0.458

High

855571

CRK
Adapter molecule crk

1

0

High-throughput

0.458

High

866973

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

963166

RL11
Large ribosomal subunit protein uL5

1

0

Small-scale

0.458

High

963167

1433Z
14-3-3 protein zeta/delta

1

0

Small-scale

0.458

High

963196

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

Small-scale

0.458

High

963208

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

963234

RNC
Ribonuclease 3

1

0

High-throughput

0.458

High

384652

CRYAB
Alpha-crystallin B chain

1

1

Small-scale

0.445

High

551780

CO6A1

1

5

High-throughput

0.445

High

554193

BMP4
Bone morphogenetic protein 4

1

2

High-throughput

0.445

High

963222

EGFL8
Epidermal growth factor-like protein 8

1

3

High-throughput

0.445

High

963249

PRG3
Proteoglycan 3

1

1

High-throughput

0.445

High

371638

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

405973

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

667704

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.437

High

713994

PML
Protein PML

1

1

High-throughput

0.437

High

761970

GRK5
G protein-coupled receptor kinase 5

1

1

High-throughput

0.437

High

891418

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.437

High

914182

EFNA3
Ephrin-A3

1

1

High-throughput

0.437

High

963174

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.437

High

963175

CUL4A
Cullin-4A

1

1

High-throughput

0.437

High

963177

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.437

High

963178

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.437

High

963179

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.437

High

963186

IF44L
Interferon-induced protein 44-like

1

1

High-throughput

0.437

High

963199

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

963216

DPF3
Zinc finger protein DPF3

1

2

Small-scale

0.437

High

963219

SPDLY
Protein Spindly

1

4

High-throughput

0.437

High

963224

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.437

High

963227

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.437

High

963235

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.437

High

229269

ANGL7
Angiopoietin-related protein 7

1

0

High-throughput

0.426

High

404755

PRIO
Major prion protein

1

0

Small-scale

0.426

High

664921

CRHBP
Corticotropin-releasing factor-binding protein

1

0

High-throughput

0.426

High

766165

NOS2
Nitric oxide synthase, inducible

1

0

Small-scale

0.426

High

963165

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.426

High

963189

RNLS
Renalase

1

0

Small-scale

0.426

High

963226

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.426

High

116513

H7C1K6
Interferon induced protein 44 like

1

1

High-throughput

0.407

High

395808

ESR1
Estrogen receptor

1

1

High-throughput

0.407

High

963215

ESR2
Estrogen receptor beta

1

1

High-throughput

0.407

High

413528

P53
Cellular tumor antigen p53

2

0

Small-scale

0.305

High

133852

FOXN3
Forkhead box protein N3

1

0

High-throughput

0.279

Low

335238

CXB5
Gap junction beta-5 protein

1

0

High-throughput

0.279

Low

563532

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.279

Low

907665

CLCN2
Chloride channel protein 2

1

0

High-throughput

0.279

Low

963163

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

963173

TWF1
Twinfilin-1

1

0

High-throughput

0.279

Low

963185

T176B
Transmembrane protein 176B

1

0

High-throughput

0.279

Low

963190

HBM
Hemoglobin subunit mu

1

0

High-throughput

0.279

Low

963193

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.279

Low

963194

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.279

Low

963200

ELOA2
Elongin-A2

1

0

High-throughput

0.279

Low

963202

FNBP4
Formin-binding protein 4

1

0

High-throughput

0.279

Low

963203

RIBC1
RIB43A-like with coiled-coils protein 1

1

0

High-throughput

0.279

Low

963204

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.279

Low

963209

O13C3
Olfactory receptor 13C3

1

0

High-throughput

0.279

Low

963220

SNX27
Sorting nexin-27

1

0

High-throughput

0.279

Low

963228

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.279

Low

963230

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

963233

PAR11
Protein mono-ADP-ribosyltransferase PARP11

1

0

High-throughput

0.279

Low

963238

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.279

Low

963245

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.279

Low

519357

MYB
Transcriptional activator Myb

1

0

Small-scale

0.269

Low

170045

AURKA
Aurora kinase A

1

0

High-throughput

0.249

Low

219855

SMAD6
Mothers against decapentaplegic homolog 6

1

0

Small-scale

0.249

Low

227458

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

293478

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

302457

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.249

Low

400589

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

615511

NELFE
Negative elongation factor E

1

0

High-throughput

0.249

Low

767865

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

774961

FUS
RNA-binding protein FUS

1

0

High-throughput

0.249

Low

822568

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.249

Low

887903

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

907358

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.249

Low

963164

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.249

Low

963168

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

963169

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

963170

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low

963171

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.249

Low

963172

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.249

Low

963182

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.249

Low

963191

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.249

Low

963195

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.249

Low

963198

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.249

Low

963201

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.249

Low

963210

NEDD1
Protein NEDD1

1

0

High-throughput

0.249

Low

963211

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.249

Low

963214

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

963231

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

963232

ANLN
Anillin

1

0

High-throughput

0.249

Low

963237

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

963239

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.249

Low

963240

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.249

Low

963242

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.249

Low

963243

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

963246

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.249

Low

963247

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.249

Low

963248

NINL
Ninein-like protein

1

0

High-throughput

0.249

Low

963251

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

0

High-throughput

0.249

Low

963252

TRI17
E3 ubiquitin-protein ligase TRIM17

1

0

Small-scale

0.249

Low

192805

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.232

Low

223616

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.232

Low

261148

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

429636

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

769691

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.232

Low

963187

CL12A
C-type lectin domain family 12 member A

1

0

High-throughput

0.232

Low

963197

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.232

Low

963217

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

0

High-throughput

0.232

Low

963221

CI085
Uncharacterized protein C9orf85

1

0

High-throughput

0.232

Low

963223

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low

963241

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025