Protein: TTC1
Tetratricopeptide repeat protein 1 (TPR repeat protein 1)

Gene: TTC1
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q99614

Gene Ontology (top 5):
GO:0005778 - peroxisomal membrane
GO:0005829 - cytosol
GO:0006457 - protein folding
GO:0051082 - unfolded protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

537770

HSP7C
Heat shock cognate 71 kDa protein

5

20

Small-scale

0.912

High

1405802

RNF41
E3 ubiquitin-protein ligase NRDP1

10

8

Small-scale

0.757

High

1405810

VAPA
Vesicle-associated membrane protein-associated protein A

7

2

High-throughput

0.749

High

761837

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.724

High

344007

HS74L
Heat shock 70 kDa protein 4L

1

20

High-throughput

0.691

High

461856

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

1405797

SPSB2
SPRY domain-containing SOCS box protein 2

4

14

High-throughput

0.691

High

333155

VAPB
Vesicle-associated membrane protein-associated protein B/C

6

2

High-throughput

0.671

High

374873

RASH
GTPase HRas

1

3

Small-scale

0.665

High

922331

LIMK2
LIM domain kinase 2

4

7

High-throughput

0.630

High

1405799

SYT11
Synaptotagmin-11

4

4

High-throughput

0.630

High

347275

BAG2
BAG family molecular chaperone regulator 2

2

4

High-throughput

0.628

High

425846

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

2

5

High-throughput

0.628

High

931078

HSP72
Heat shock-related 70 kDa protein 2

1

20

High-throughput

0.618

High

1289570

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.618

High

1340445

DDX55
ATP-dependent RNA helicase DDX55

1

2

High-throughput

0.618

High

1405796

DNJC7
DnaJ homolog subfamily C member 7

1

20

High-throughput

0.618

High

1139815

SETB1
Histone-lysine N-methyltransferase SETDB1

3

3

High-throughput

0.609

High

1405825

SRPRB
Signal recognition particle receptor subunit beta

3

4

High-throughput

0.609

High

1041462

ACY1
Aminoacylase-1

2

3

High-throughput

0.608

High

1405815

NB5R1
NADH-cytochrome b5 reductase 1

2

3

High-throughput

0.606

High

1382372

SPSB4
SPRY domain-containing SOCS box protein 4

2

14

High-throughput

0.601

High

1384498

SPSB1
SPRY domain-containing SOCS box protein 1

2

14

High-throughput

0.601

High

516065

ST1A4
Sulfotransferase 1A4

2

0

High-throughput

0.585

High

1350423

BICD2
Protein bicaudal D homolog 2

2

7

High-throughput

0.584

High

1366532

AKAP1
A-kinase anchor protein 1, mitochondrial

2

7

High-throughput

0.584

High

278949

PEX14
Peroxisomal membrane protein PEX14

2

0

Small-scale

0.563

High

1128990

I5P1
Inositol polyphosphate-5-phosphatase A

2

2

High-throughput

0.558

High

1384529

Q96BE0
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.553

High

1085466

SRBP2
Sterol regulatory element-binding protein 2

1

3

High-throughput

0.541

High

274718

DNJB6
DnaJ homolog subfamily B member 6

1

19

High-throughput

0.536

High

347883

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.536

High

1161372

HIF1A
Hypoxia-inducible factor 1-alpha

1

10

High-throughput

0.536

High

1253791

QSOX2
Sulfhydryl oxidase 2

1

8

High-throughput

0.536

High

1259448

TBA1A
Tubulin alpha-1A chain

1

13

High-throughput

0.536

High

1405808

SPHK1
Sphingosine kinase 1

1

1

High-throughput

0.536

High

1405809

HPBP1
Hsp70-binding protein 1

1

4

High-throughput

0.536

High

1405813

KLH14
Kelch-like protein 14

1

6

High-throughput

0.536

High

721453

GNA15
Guanine nucleotide-binding protein subunit alpha-15

1

8

Small-scale

0.535

High

418726

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

7

Small-scale

0.515

High

989779

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

6

Small-scale

0.515

High

415814

HSPB1
Heat shock protein beta-1

1

6

High-throughput

0.515

High

843905

HD
Huntingtin

1

2

High-throughput

0.515

High

1105165

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.513

High

1399911

SORC2
VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]

1

0

High-throughput

0.513

High

1405798

SIKE1
Suppressor of IKBKE 1

1

0

High-throughput

0.513

High

776115

SOX5
Transcription factor SOX-5

1

4

High-throughput

0.494

High

49376

PLS5
Phospholipid scramblase family member 5

1

1

High-throughput

0.489

High

129794

CBX4
E3 SUMO-protein ligase CBX4

1

1

High-throughput

0.489

High

296735

TUSC2
Tumor suppressor candidate 2

1

2

High-throughput

0.489

High

1405822

NTNG1
Netrin-G1

1

5

High-throughput

0.489

High

220798

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

2

High-throughput

0.481

High

1193557

CRY2
Cryptochrome-2

1

7

Small-scale

0.481

High

1405806

NDE1
Nuclear distribution protein nudE homolog 1

1

8

High-throughput

0.481

High

133787

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

2

High-throughput

0.479

High

156657

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

17

High-throughput

0.479

High

173266

XPO1
Exportin-1

1

6

High-throughput

0.479

High

273708

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

6

High-throughput

0.479

High

326607

MFN2
Mitofusin-2

1

2

High-throughput

0.479

High

440184

LCK
Tyrosine-protein kinase Lck

1

11

High-throughput

0.479

High

831298

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

880661

LMAN1
Protein ERGIC-53

1

4

High-throughput

0.479

High

947367

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

8

High-throughput

0.479

High

958498

ACTZ
Alpha-centractin

1

11

High-throughput

0.479

High

1147667

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

2

High-throughput

0.479

High

1199361

GLE1
mRNA export factor GLE1

1

4

High-throughput

0.479

High

1214562

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.479

High

1293651

DYR2
Dihydrofolate reductase 2, mitochondrial

1

2

High-throughput

0.479

High

1333321

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1364545

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

1405816

ANC2
Anaphase-promoting complex subunit 2

1

6

High-throughput

0.479

High

1405817

FZR1
Fizzy-related protein homolog

1

15

High-throughput

0.479

High

1405819

UBP18
Ubl carboxyl-terminal hydrolase 18

1

7

High-throughput

0.479

High

1405824

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

893524

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

8

Small-scale

0.470

High

1353167

GANC
Neutral alpha-glucosidase C

1

1

High-throughput

0.470

High

705526

GRN
Progranulin

1

1

High-throughput

0.470

High

1405811

SH3B4
SH3 domain-binding protein 4

1

1

High-throughput

0.464

High

369206

OAS1
2'-5'-oligoadenylate synthase 1

1

1

High-throughput

0.445

High

404883

PRIO
Major prion protein

1

3

High-throughput

0.445

High

564267

CFTR
Cystic fibrosis transmembrane conductance regulator

1

9

High-throughput

0.445

High

598764

ANFB
Natriuretic peptides B

1

2

High-throughput

0.445

High

1315706

DND1
Dead end protein homolog 1

1

2

High-throughput

0.445

High

1405814

RBX2
RING-box protein 2

1

1

High-throughput

0.445

High

522291

OSTP
Osteopontin

1

2

Small-scale

0.439

High

75884

B4DE84
cDNA FLJ55955, highly similar to HECT domain and RCC1-like domain-containing protein 2

1

5

High-throughput

0.437

High

106532

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

168892

PLD2
Phospholipase D2

1

7

High-throughput

0.437

High

246898

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.437

High

364173

MOS
Proto-oncogene serine/threonine-protein kinase mos

1

4

High-throughput

0.437

High

589499

RFA2
Replication protein A 32 kDa subunit

1

10

High-throughput

0.437

High

607036

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.437

High

696312

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

12

High-throughput

0.437

High

768983

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

777754

VGFR3
Vascular endothelial growth factor receptor 3

1

7

High-throughput

0.437

High

1096798

RFA4
Replication protein A 30 kDa subunit

1

10

High-throughput

0.437

High

1122909

SIM2
Single-minded homolog 2

1

10

High-throughput

0.437

High

1233440

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

1255216

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.437

High

1276696

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

1286375

NEK8
Serine/threonine-protein kinase Nek8

1

18

High-throughput

0.437

High

1288493

LBN
Limbin

1

2

High-throughput

0.437

High

1330603

PLD5
Inactive phospholipase D5

1

2

High-throughput

0.437

High

1349030

DJB14
DnaJ homolog subfamily B member 14

1

20

High-throughput

0.437

High

1385686

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.437

High

1405803

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.437

High

1405804

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

9

High-throughput

0.437

High

1405805

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.437

High

1405807

DJB12
DnaJ homolog subfamily B member 12

1

19

High-throughput

0.437

High

1405812

SEP10
Septin-10

1

2

High-throughput

0.437

High

1405818

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.437

High

1405821

DYN3
Dynamin-3

1

3

High-throughput

0.437

High

1405826

MTCH2
Mitochondrial carrier homolog 2

1

15

High-throughput

0.437

High

1144790

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

High-throughput

0.426

High

3437

A0A0S2Z528
Proline-serine-threonine phosphatase interacting protein 1 isoform 3

1

1

High-throughput

0.417

High

116774

I3L3G9
NudE neurodevelopment protein 1

1

7

High-throughput

0.417

High

81640

B5MC51
Protein phosphatase 1 regulatory subunit 14

1

11

High-throughput

0.407

High

261257

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

330286

VENTX
Homeobox protein VENTX

1

7

High-throughput

0.407

High

1397148

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

20

High-throughput

0.407

High

1405800

S12A9
Solute carrier family 12 member 9

1

17

High-throughput

0.407

High

1405820

S12A4
Solute carrier family 12 member 4

1

17

High-throughput

0.407

High

1405823

S27A6
Long-chain fatty acid transport protein 6

1

10

High-throughput

0.407

High

1405801

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

0

High-throughput

0.313

High

1060029

SCN1B
Sodium channel regulatory subunit beta-1

1

0

High-throughput

0.279

Low

1405827

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

301655

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1008051

KCJ10
ATP-sensitive inward rectifier potassium channel 10

1

0

High-throughput

0.249

Low

320489

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.232

Low

327421

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025