Protein: HARS1
Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)

Gene: HARS1
Organism: Homo sapiens
Interactions: 57
UniProt ID: P12081

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004821 - histidine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551698

SYHM
Histidine--tRNA ligase, mitochondrial

5

14

High-throughput

0.922

High

551684

HARS1
Histidine--tRNA ligase, cytoplasmic

2

15

Small-scale

0.789

High

551721

SGCZ
Zeta-sarcoglycan

3

1

High-throughput

0.599

High

551723

TNIK
TRAF2 and NCK-interacting protein kinase

2

3

High-throughput

0.590

High

551711

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

High-throughput

0.571

High

551689

EF1B
Elongation factor 1-beta

1

1

Small-scale

0.561

High

551690

EF1G
Elongation factor 1-gamma

1

3

Small-scale

0.561

High

551701

TTC3
E3 ubiquitin-protein ligase TTC3

1

8

High-throughput

0.541

High

58694

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

0

High-throughput

0.513

High

551688

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

0

High-throughput

0.513

High

185389

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

551702

PRS8
26S proteasome regulatory subunit 8

1

1

High-throughput

0.481

High

156894

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

240606

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

400204

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

411267

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

536390

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

551687

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

551692

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

551695

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

551699

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

551703

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

551705

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.479

High

551707

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

551709

PDK2
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

551714

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

551716

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

551717

ASB11
Ankyrin repeat and SOCS box protein 11

1

2

High-throughput

0.479

High

551718

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

551719

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.479

High

551720

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

551725

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

551694

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

551696

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

551715

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

142271

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.445

High

528960

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

551708

DAG1
Dystroglycan 1

1

1

Small-scale

0.445

High

551710

NEDD8
Ubiquitin-like protein NEDD8

1

1

Small-scale

0.445

High

551712

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

551722

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

551724

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

352901

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

371035

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

551685

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

551691

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

551693

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

551686

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

551706

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

261068

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

551700

GPC3
Glypican-3

1

1

High-throughput

0.407

High

551704

Q08AT0
SGCZ protein

1

1

High-throughput

0.407

High

551697

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

377383

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

551713

SPG17
Sperm-associated antigen 17

1

0

High-throughput

0.249

Low

330027

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025