Protein: FPPS
Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)

Gene: FPPS, FDPS
Organism: Homo sapiens
Interactions: 77
UniProt ID: P14324

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004161 - dimethylallyltranstransferase activity
GO:0004337 - (2E,6E)-farnesyl diphosphate synthase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571772

DPS1
All trans-polyprenyl-diphosphate synthase PDSS1

2

13

High-throughput

0.811

High

571779

DLP1
All trans-polyprenyl-diphosphate synthase PDSS2

2

13

High-throughput

0.811

High

571745

FPPS
Farnesyl pyrophosphate synthase

1

10

Small-scale

0.647

High

571757

ATX1
Ataxin-1

2

2

High-throughput

0.620

High

571776

RN19B
E3 ubiquitin-protein ligase RNF19B

2

1

High-throughput

0.606

High

295794

FACE1
CAAX prenyl protease 1 homolog

2

0

High-throughput

0.602

High

560827

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

2

0

High-throughput

0.602

High

571749

GCSP
Glycine dehydrogenase

2

0

High-throughput

0.602

High

571766

PSME4
Proteasome activator complex subunit 4

2

0

High-throughput

0.602

High

571780

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.602

High

240643

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

571789

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

0

High-throughput

0.580

High

350347

ABHGA
Phosphatidylserine lipase ABHD16A

2

1

High-throughput

0.553

High

230249

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.551

High

571760

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.547

High

571793

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.536

High

541307

FGFR1
Fibroblast growth factor receptor 1

1

1

Small-scale

0.527

High

130822

DFFA
DNA fragmentation factor subunit alpha

1

0

High-throughput

0.513

High

445712

ENOA
Alpha-enolase

1

0

High-throughput

0.513

High

459434

PROF1
Profilin-1

1

0

High-throughput

0.513

High

528987

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

539583

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.513

High

571746

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.513

High

571751

CDC27
Cell division cycle protein 27 homolog

1

0

High-throughput

0.513

High

571754

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.513

High

571769

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.513

High

571783

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.513

High

571785

NEB2
Neurabin-2

1

0

High-throughput

0.513

High

571786

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.513

High

571787

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.513

High

571791

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

571756

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.493

High

571768

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.493

High

571758

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

571764

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

571777

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

128747

MEN1
Menin

1

0

High-throughput

0.458

High

293144

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

362689

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

371060

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

400220

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

536413

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

571747

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

571750

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

571752

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

571753

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

571759

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

571761

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

571765

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

571767

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.458

High

571782

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

571792

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

571795

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

Small-scale

0.458

High

571796

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

571798

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.458

High

571762

TAGL
Transgelin

1

1

High-throughput

0.445

High

571763

DDR1
Epithelial discoidin domain-containing receptor 1

1

2

Small-scale

0.445

High

571788

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

411288

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

404650

PRIO
Major prion protein

1

0

High-throughput

0.426

High

571748

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

571771

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

571774

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

571784

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

571755

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

571773

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

2

0

High-throughput

0.328

High

571775

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

0

High-throughput

0.328

High

571797

PCYOX
Prenylcysteine oxidase 1

2

0

High-throughput

0.328

High

571781

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.316

High

105245

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

571790

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

318599

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

571770

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

571778

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

571794

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

268951

LIRB3
Leukocyte immunoglobulin-like receptor subfamily B member 3

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025