Protein: SPPL3
Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)

Gene: SPPL3
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q8TCT6

Gene Ontology (top 5):
GO:0005791 - rough endoplasmic reticulum
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane
GO:0006465 - signal peptide processing
GO:0007204 - positive regulation of cytosolic calcium ion concentration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

854557

S15A1
Solute carrier family 15 member 1

2

1

High-throughput

0.628

High

855359

5HT3A
5-hydroxytryptamine receptor 3A

2

10

High-throughput

0.628

High

1057564

ACHD
Acetylcholine receptor subunit delta

2

8

High-throughput

0.628

High

1153288

AAAT
Neutral amino acid transporter B(0)

2

1

High-throughput

0.628

High

1159087

C3AR
C3a anaphylatoxin chemotactic receptor

2

3

High-throughput

0.628

High

1291752

S22AG
Solute carrier family 22 member 16

2

4

High-throughput

0.628

High

1316332

AGRG5
Adhesion G-protein coupled receptor G5

2

4

High-throughput

0.628

High

1350001

S39A8
Metal cation symporter ZIP8

2

6

High-throughput

0.628

High

1350002

YIPF3
Protein YIPF3

2

1

High-throughput

0.628

High

1350005

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

2

3

High-throughput

0.628

High

1350010

P2RX2
P2X purinoceptor 2

2

1

High-throughput

0.628

High

1142510

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.602

High

1292014

TPRA1
Transmembrane protein adipocyte-associated 1

2

0

High-throughput

0.602

High

1349997

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

1349998

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

2

0

High-throughput

0.602

High

1350003

S22A4
Solute carrier family 22 member 4

2

4

High-throughput

0.601

High

926808

VMAT1
Chromaffin granule amine transporter

2

5

High-throughput

0.574

High

133286

P2Y10
Putative P2Y purinoceptor 10

1

6

High-throughput

0.536

High

165997

FFAR1
Free fatty acid receptor 1

1

5

High-throughput

0.536

High

182684

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.536

High

607960

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

8

High-throughput

0.536

High

640429

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

5

High-throughput

0.536

High

719820

V2R
Vasopressin V2 receptor

1

1

High-throughput

0.536

High

733025

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.536

High

851183

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

6

High-throughput

0.536

High

867650

GPR12
G-protein coupled receptor 12

1

2

High-throughput

0.536

High

888935

TMEDA
Transmembrane emp24 domain-containing protein 10

1

5

High-throughput

0.536

High

907039

CCR6
C-C chemokine receptor type 6

1

4

High-throughput

0.536

High

1022432

IDD
Integral membrane protein DGCR2/IDD

1

2

High-throughput

0.536

High

1101602

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

5

High-throughput

0.536

High

1239019

NIPA3
Magnesium transporter NIPA3

1

2

High-throughput

0.536

High

1330322

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.536

High

1348610

S7A14
Solute carrier family 7 member 14

1

1

High-throughput

0.536

High

1349999

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.536

High

1350004

TSN10
Tetraspanin-10

1

1

High-throughput

0.536

High

1350008

AT133
Polyamine-transporting ATPase 13A3

1

8

High-throughput

0.536

High

1350014

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.536

High

378642

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.513

High

611925

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

612712

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.513

High

832434

OPRX
Nociceptin receptor

1

0

High-throughput

0.513

High

975824

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.513

High

986117

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.513

High

1027610

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

1057816

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.513

High

1350000

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

1350011

SC5A6
Sodium-dependent multivitamin transporter

1

0

High-throughput

0.513

High

1308907

S22A9
Organic anion transporter 7

1

4

High-throughput

0.489

High

1350007

TM231
Transmembrane protein 231

1

1

High-throughput

0.489

High

1350012

SL9A8
Sodium/hydrogen exchanger 8

1

1

High-throughput

0.489

High

845084

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.445

High

1139517

S39AE
Metal cation symporter ZIP14

1

6

High-throughput

0.445

High

1274082

MOT14
Monocarboxylate transporter 14

1

1

High-throughput

0.445

High

1337875

ZNT7
Zinc transporter 7

1

3

High-throughput

0.445

High

130846

DFFA
DNA fragmentation factor subunit alpha

1

0

High-throughput

0.426

High

704050

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.426

High

1350006

GHITM
Growth hormone-inducible transmembrane protein

1

3

High-throughput

0.407

High

1350009

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.279

Low

1350013

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.279

Low

1291430

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025