Protein: E2F6
Transcription factor E2F6 (E2F-6)

Gene: E2F6
Organism: Homo sapiens
Interactions: 180
UniProt ID: O75461

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

265646

TFDP2
Transcription factor Dp-2

13

20

Small-scale

0.986

High

265645

TFDP1
Transcription factor Dp-1

13

20

Small-scale

0.985

High

265681

RYBP
RING1 and YY1-binding protein

8

7

Small-scale

0.753

High

265707

PCGF6
Polycomb group RING finger protein 6

7

20

Small-scale

0.746

High

265695

LMBL2
Lethal(3)malignant brain tumor-like protein 2

6

14

Small-scale

0.736

High

265625

WDR5
WD repeat-containing protein 5

6

6

Small-scale

0.735

High

265700

RING2
E3 ubiquitin-protein ligase RING2

6

20

Small-scale

0.733

High

265624

MAX
Protein max

5

10

Small-scale

0.718

High

265640

CBX3
Chromobox protein homolog 3

5

10

Small-scale

0.718

High

265677

MGAP
MAX gene-associated protein

5

5

High-throughput

0.718

High

265679

YAF2
YY1-associated factor 2

5

7

High-throughput

0.718

High

265642

HDAC1
Histone deacetylase 1

4

8

High-throughput

0.699

High

265672

COMD6
COMM domain-containing protein 6

4

1

High-throughput

0.699

High

265711

COMD4
COMM domain-containing protein 4

4

2

High-throughput

0.699

High

265636

RING1
E3 ubiquitin-protein ligase RING1

3

20

Small-scale

0.681

High

265682

COMD1
COMM domain-containing protein 1

3

2

High-throughput

0.675

High

265721

COMD8
COMM domain-containing protein 8

3

2

High-throughput

0.675

High

265596

PRS6A
26S proteasome regulatory subunit 6A

3

5

High-throughput

0.667

High

265680

MIER2
Mesoderm induction early response protein 2

3

4

High-throughput

0.667

High

265735

CARD8
Caspase recruitment domain-containing protein 8

3

0

High-throughput

0.638

High

265612

KDM5C
Lysine-specific demethylase 5C

2

1

Small-scale

0.628

High

265631

CBX1
Chromobox protein homolog 1

2

10

High-throughput

0.628

High

265691

HDAC2
Histone deacetylase 2

2

8

High-throughput

0.628

High

135191

E2F3
Transcription factor E2F3

1

18

High-throughput

0.618

High

265585

RB
Retinoblastoma-associated protein

1

20

High-throughput

0.618

High

265633

E2F1
Transcription factor E2F1

1

15

High-throughput

0.618

High

265647

E2F2
Transcription factor E2F2

1

15

High-throughput

0.618

High

265654

E2F5
Transcription factor E2F5

1

14

High-throughput

0.618

High

265658

E2F4
Transcription factor E2F4

1

14

High-throughput

0.618

High

265718

CBX8
Chromobox protein homolog 8

2

10

High-throughput

0.611

High

265714

EPC1
Enhancer of polycomb homolog 1

2

2

Small-scale

0.606

High

265616

LEG7
Galectin-7

2

0

High-throughput

0.602

High

265734

TCF19
Transcription factor 19

2

0

High-throughput

0.602

High

265610

BMI1
Polycomb complex protein BMI-1

2

20

Small-scale

0.601

High

265657

EZH2
Histone-lysine N-methyltransferase EZH2

2

6

Small-scale

0.601

High

265577

MYC
Myc proto-oncogene protein

2

18

High-throughput

0.584

High

265611

PCGF2
Polycomb group RING finger protein 2

2

20

Small-scale

0.584

High

265622

KLF3
Krueppel-like factor 3

2

13

High-throughput

0.584

High

265637

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

1

High-throughput

0.574

High

265720

ASB6
Ankyrin repeat and SOCS box protein 6

2

1

High-throughput

0.574

High

265620

SMCA4
Transcription activator BRG1

1

8

Small-scale

0.573

High

265690

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

3

High-throughput

0.542

High

198318

KLK10
Kallikrein-10

1

1

High-throughput

0.536

High

265581

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.536

High

265597

FILA
Filaggrin

1

3

High-throughput

0.536

High

265606

S10A7
Protein S100-A7

1

2

High-throughput

0.536

High

265607

CASPE
Caspase-14

1

1

High-throughput

0.536

High

265608

S10AB
Protein S100-A11

1

2

High-throughput

0.536

High

265644

TRI29
Tripartite motif-containing protein 29

1

2

High-throughput

0.536

High

265648

RRP5
Protein RRP5 homolog

1

4

High-throughput

0.536

High

265704

TBA1C
Tubulin alpha-1C chain

1

2

High-throughput

0.536

High

265709

COMD5
COMM domain-containing protein 5

1

1

High-throughput

0.536

High

265623

KR107
Keratin-associated protein 10-7

1

1

High-throughput

0.523

High

265583

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

265588

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.513

High

265595

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

265659

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.513

High

265582

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

265729

DNM3L
DNA

1

4

Small-scale

0.501

High

245764

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

265574

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.489

High

265576

CYTS
Cystatin-S

1

2

High-throughput

0.489

High

265584

APOD
Apolipoprotein D

1

2

High-throughput

0.489

High

265589

CYTT
Cystatin-SA

1

2

High-throughput

0.489

High

265590

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

265600

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.489

High

265605

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

265618

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

265656

CYTM
Cystatin-M

1

2

High-throughput

0.489

High

265665

ZMYM4
Zinc finger MYM-type protein 4

1

2

High-throughput

0.489

High

265684

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.489

High

265698

CPNS2
Calpain small subunit 2

1

2

High-throughput

0.489

High

265703

DHB14
17-beta-hydroxysteroid dehydrogenase 14

1

1

High-throughput

0.489

High

265603

DNMT1
DNA

1

3

Small-scale

0.481

High

265661

BRDT
Bromodomain testis-specific protein

1

18

Small-scale

0.481

High

265688

FOG2
Zinc finger protein ZFPM2

1

1

Small-scale

0.481

High

265722

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

5

Small-scale

0.481

High

265736

ZBT32
Zinc finger and BTB domain-containing protein 32

1

1

Small-scale

0.481

High

152565

KMT2D
Histone-lysine N-methyltransferase 2D

1

12

Small-scale

0.479

High

179490

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

197634

CRX
Cone-rod homeobox protein

1

7

High-throughput

0.479

High

225695

SOX15
Transcription factor SOX-15

1

4

High-throughput

0.479

High

231913

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.479

High

257730

SIN3B
Paired amphipathic helix protein Sin3b

1

3

Small-scale

0.479

High

265571

EED
Polycomb protein EED

1

5

Small-scale

0.479

High

265572

DNJC8
DnaJ homolog subfamily C member 8

1

4

High-throughput

0.479

High

265573

KLF8
Krueppel-like factor 8

1

15

High-throughput

0.479

High

265580

ESR1
Estrogen receptor

1

6

Small-scale

0.479

High

265586

LYN
Tyrosine-protein kinase Lyn

1

2

Small-scale

0.479

High

265587

NFIC
Nuclear factor 1 C-type

1

5

High-throughput

0.479

High

265592

MYB
Transcriptional activator Myb

1

7

High-throughput

0.479

High

265594

IRF1
Interferon regulatory factor 1

1

1

High-throughput

0.479

High

265602

DNJB1
DnaJ homolog subfamily B member 1

1

4

High-throughput

0.479

High

265604

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.479

High

265609

ELF1
ETS-related transcription factor Elf-1

1

7

High-throughput

0.479

High

265613

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

High-throughput

0.479

High

265614

ELK3
ETS domain-containing protein Elk-3

1

6

High-throughput

0.479

High

265617

CENPA
Histone H3-like centromeric protein A

1

4

High-throughput

0.479

High

265619

LHX2
LIM/homeobox protein Lhx2

1

3

High-throughput

0.479

High

265626

H4
Histone H4

1

1

High-throughput

0.479

High

265630

PHC1
Polyhomeotic-like protein 1

1

18

High-throughput

0.479

High

265634

KMT2A
Histone-lysine N-methyltransferase 2A

1

10

Small-scale

0.479

High

265635

MAD1
Max dimerization protein 1

1

12

Small-scale

0.479

High

265638

NFIA
Nuclear factor 1 A-type

1

5

High-throughput

0.479

High

265643

KLF9
Krueppel-like factor 9

1

15

High-throughput

0.479

High

265649

CBX2
Chromobox protein homolog 2

1

10

High-throughput

0.479

High

265650

NFIX
Nuclear factor 1 X-type

1

6

High-throughput

0.479

High

265651

BRD3
Bromodomain-containing protein 3

1

17

High-throughput

0.479

High

265652

IRF4
Interferon regulatory factor 4

1

1

High-throughput

0.479

High

265653

ZMY11
Zinc finger MYND domain-containing protein 11

1

15

Small-scale

0.479

High

265655

ELF2
ETS-related transcription factor Elf-2

1

5

High-throughput

0.479

High

265660

PCGF3
Polycomb group RING finger protein 3

1

20

High-throughput

0.479

High

265662

BCORL
BCL-6 corepressor-like protein 1

1

7

High-throughput

0.479

High

265667

BCOR
BCL-6 corepressor

1

7

High-throughput

0.479

High

265671

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

265673

PCGF5
Polycomb group RING finger protein 5

1

20

High-throughput

0.479

High

265674

PB1
Protein polybromo-1

1

13

Small-scale

0.479

High

265683

PHC3
Polyhomeotic-like protein 3

1

11

High-throughput

0.479

High

265685

NUP43
Nucleoporin Nup43

1

14

High-throughput

0.479

High

265686

KDM2B
Lysine-specific demethylase 2B

1

6

High-throughput

0.479

High

265692

EZH1
Histone-lysine N-methyltransferase EZH1

1

6

Small-scale

0.479

High

265693

SMRC1
SWI/SNF complex subunit SMARCC1

1

12

Small-scale

0.479

High

265694

LHX4
LIM/homeobox protein Lhx4

1

3

High-throughput

0.479

High

265696

PF21A
PHD finger protein 21A

1

6

High-throughput

0.479

High

265697

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

17

Small-scale

0.479

High

265699

CIC
Protein capicua homolog

1

8

High-throughput

0.479

High

265701

FEV
Protein FEV

1

5

High-throughput

0.479

High

265702

ELF4
ETS-related transcription factor Elf-4

1

6

High-throughput

0.479

High

265705

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

265706

KLF16
Krueppel-like factor 16

1

14

High-throughput

0.479

High

265710

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

265715

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

8

High-throughput

0.479

High

265716

SOX17
Transcription factor SOX-17

1

9

High-throughput

0.479

High

265719

DJC17
DnaJ homolog subfamily C member 17

1

5

High-throughput

0.479

High

265723

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

265724

LHX3
LIM/homeobox protein Lhx3

1

3

High-throughput

0.479

High

265725

ZMYM2
Zinc finger MYM-type protein 2

1

2

High-throughput

0.479

High

265726

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

265728

KLF15
Krueppel-like factor 15

1

15

High-throughput

0.479

High

265730

RCOR1
REST corepressor 1

1

7

High-throughput

0.479

High

265731

ELF5
ETS-related transcription factor Elf-5

1

5

High-throughput

0.479

High

265732

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

10

Small-scale

0.479

High

265733

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

3

Small-scale

0.479

High

265738

KLF12
Krueppel-like factor 12

1

13

High-throughput

0.479

High

265601

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.460

High

265639

ZBT17
Zinc finger and BTB domain-containing protein 17

1

0

Small-scale

0.460

High

265669

CENPU
Centromere protein U

1

0

Small-scale

0.460

High

265708

IN80B
INO80 complex subunit B

1

0

Small-scale

0.460

High

265712

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

Small-scale

0.460

High

262335

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

265621

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

High-throughput

0.458

High

265627

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

265663

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.458

High

265689

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

265737

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

265641

PD2R
Prostaglandin D2 receptor

1

1

Small-scale

0.437

High

265675

MIB1
E3 ubiquitin-protein ligase MIB1

1

5

High-throughput

0.437

High

265678

DHX40
Probable ATP-dependent RNA helicase DHX40

1

3

High-throughput

0.437

High

265578

IGHG1
Immunoglobulin heavy constant gamma 1

1

1

High-throughput

0.407

High

265687

POF1B
Protein POF1B

2

0

High-throughput

0.328

High

265593

ARAF
Serine/threonine-protein kinase A-Raf

1

0

High-throughput

0.282

High

259809

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

265575

PLMN
Plasminogen

1

0

High-throughput

0.279

Low

265579

SMR3B
Submaxillary gland androgen-regulated protein 3B

1

0

High-throughput

0.279

Low

265598

SPR1B
Cornifin-B

1

0

High-throughput

0.279

Low

265599

SPR2E
Small proline-rich protein 2E

1

0

High-throughput

0.279

Low

265615

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.279

Low

265628

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.279

Low

265664

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.279

Low

265666

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

265668

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

265670

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

265676

SPA12
Serpin A12

1

0

High-throughput

0.279

Low

265713

RNAS7
Ribonuclease 7

1

0

High-throughput

0.279

Low

265727

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

148209

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

265629

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.249

Low

265632

REEP5
Receptor expression-enhancing protein 5

1

0

Small-scale

0.249

Low

265717

FBRS
Probable fibrosin-1

1

0

High-throughput

0.249

Low

265591

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024