Protein: SYCC
Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)

Gene: SYCC, CARS1
Organism: Homo sapiens
Interactions: 56
UniProt ID: P49589

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004817 - cysteine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

687928

EF1G
Elongation factor 1-gamma

5

3

Small-scale

0.721

High

884587

EF1A2
Elongation factor 1-alpha 2

3

5

High-throughput

0.662

High

884586

EF1A1
Elongation factor 1-alpha 1

2

5

High-throughput

0.628

High

884600

ABTB1
Ankyrin repeat and BTB/POZ domain-containing protein 1

2

2

High-throughput

0.628

High

884580

SYCC
Cysteine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.618

High

714792

EF1D
Elongation factor 1-delta

2

0

High-throughput

0.602

High

241076

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

529340

TAU
Microtubule-associated protein tau

2

3

High-throughput

0.571

High

884594

A16L1
Autophagy-related protein 16-1

2

3

High-throughput

0.571

High

884606

TRI55
Tripartite motif-containing protein 55

1

7

High-throughput

0.541

High

884610

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

1

High-throughput

0.536

High

884593

KMT5B
Histone-lysine N-methyltransferase KMT5B

1

0

High-throughput

0.513

High

421714

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

884603

ERP27
Endoplasmic reticulum resident protein 27

1

1

High-throughput

0.489

High

884601

TRI63
E3 ubiquitin-protein ligase TRIM63

1

5

High-throughput

0.481

High

884589

TP4A2
Protein tyrosine phosphatase type IVA 2

1

0

Small-scale

0.480

High

131825

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

220753

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

4

Small-scale

0.479

High

345522

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

411573

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

798845

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

884581

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.479

High

884585

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

884592

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

884595

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

884597

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

884598

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

884599

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

884605

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

4

Small-scale

0.479

High

884608

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

884612

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

884613

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

4

Small-scale

0.479

High

884614

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

4

Small-scale

0.479

High

884617

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.479

High

159564

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

884591

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

884602

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

884584

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.457

High

884609

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

884611

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

884615

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

105567

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

588187

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

694910

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

767683

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

884588

SRSF4
Serine/arginine-rich splicing factor 4

1

1

High-throughput

0.437

High

884596

PB1
Protein polybromo-1

1

1

High-throughput

0.437

High

884616

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

705277

GRN
Progranulin

1

1

High-throughput

0.407

High

884607

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

884583

AF17
Protein AF-17

2

0

High-throughput

0.328

High

884604

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

0

High-throughput

0.279

Low

378009

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

884582

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low

884590

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025