Protein: MMSA
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) (Malonate-semialdehyde dehydrogenase [acylating])

Gene: MMSA, ALDH6A1
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q02252

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004491 - methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

423894

ALDH2
Aldehyde dehydrogenase, mitochondrial

3

14

High-throughput

0.861

High

1036118

AL8A1
2-aminomuconic semialdehyde dehydrogenase

3

14

High-throughput

0.770

High

1036123

DPOG2
DNA polymerase subunit gamma-2

3

0

High-throughput

0.634

High

1036110

ABRX1
BRCA1-A complex subunit Abraxas 1

2

0

High-throughput

0.602

High

1036107

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

3

High-throughput

0.584

High

528440

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

2

High-throughput

0.536

High

529659

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

271036

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

275278

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

416010

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.513

High

611839

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

1025212

HXC5
Homeobox protein Hox-C5

1

0

High-throughput

0.513

High

1036109

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1036121

BEX4
Protein BEX4

1

0

High-throughput

0.513

High

185621

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.501

High

241441

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

1036115

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1036122

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

681789

RBTN2
Rhombotin-2

1

0

High-throughput

0.460

High

536999

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

1036106

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1036112

TM10C
tRNA methyltransferase 10 homolog C

1

0

Small-scale

0.458

High

1036124

DUS12
Dual specificity protein phosphatase 12

1

0

High-throughput

0.458

High

330123

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.445

High

593584

GDC
Solute carrier family 25 member 16

1

1

High-throughput

0.445

High

653260

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.445

High

1036113

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

1036120

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

105782

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

1036111

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1036119

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

4

Small-scale

0.437

High

369176

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

1036105

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

1036114

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.426

High

1036116

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.426

High

1036117

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

1036126

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.426

High

142325

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.407

High

868051

OR1D4
Olfactory receptor 1D4

1

2

High-throughput

0.407

High

1036125

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.407

High

562004

LAMP2
Lysosome-associated membrane glycoprotein 2

2

0

High-throughput

0.328

High

866375

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.279

Low

1036108

DB136
Defensin beta 136

1

0

High-throughput

0.279

Low

377542

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

466887

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025