Protein: ARHG6
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)

Gene: ARHG6, ARHGEF6
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q15052

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005911 - cell-cell junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026910

PAK2
Serine/threonine-protein kinase PAK 2

9

16

Small-scale

0.973

High

1026167

PAK1
Serine/threonine-protein kinase PAK 1

9

16

High-throughput

0.973

High

1049706

ARHG7
Rho guanine nucleotide exchange factor 7

6

14

Small-scale

0.948

High

1050107

GIT2
ARF GTPase-activating protein GIT2

6

20

High-throughput

0.946

High

1066061

GIT1
ARF GTPase-activating protein GIT1

6

20

Small-scale

0.945

High

209055

NCK2
Cytoplasmic protein NCK2

3

19

High-throughput

0.861

High

925289

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.827

High

1066054

SPN90
NCK-interacting protein with SH3 domain

2

3

High-throughput

0.811

High

1049952

SCRIB
Protein scribble homolog

2

4

Small-scale

0.776

High

894026

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.754

High

200775

ARHG9
Rho guanine nucleotide exchange factor 9

2

14

High-throughput

0.737

High

1066026

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

8

High-throughput

0.726

High

158102

TX1B3
Tax1-binding protein 3

1

12

High-throughput

0.691

High

557698

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.691

High

586759

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.691

High

1066060

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

11

High-throughput

0.691

High

243142

SH21A
SH2 domain-containing protein 1A

1

20

Small-scale

0.683

High

928917

SKP1
S-phase kinase-associated protein 1

3

2

High-throughput

0.667

High

1066041

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

0

High-throughput

0.661

High

1066046

SH3G3
Endophilin-A3

1

18

High-throughput

0.656

High

863098

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

0

High-throughput

0.638

High

823398

PAXI
Paxillin

3

11

High-throughput

0.633

High

1066053

FBX28
F-box only protein 28

4

1

High-throughput

0.630

High

238964

LPXN
Leupaxin

2

12

High-throughput

0.628

High

1066051

SYNCI
Syncoilin

2

8

High-throughput

0.628

High

1043658

ASPP2
Apoptosis-stimulating of p53 protein 2

1

9

High-throughput

0.621

High

1066040

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

8

Small-scale

0.621

High

148836

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.618

High

545388

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

738545

TGFR1
TGF-beta receptor type-1

1

5

Small-scale

0.618

High

739979

TGFR2
TGF-beta receptor type-2

1

5

Small-scale

0.618

High

892381

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

1066025

ARHG6
Rho guanine nucleotide exchange factor 6

1

14

Small-scale

0.618

High

1066028

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.618

High

1066031

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.618

High

1066032

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1066045

NEB2
Neurabin-2

1

15

High-throughput

0.618

High

253016

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

1020667

TRAF2
TNF receptor-associated factor 2

2

7

High-throughput

0.606

High

1066033

K1C27
Keratin, type I cytoskeletal 27

2

1

High-throughput

0.606

High

1066039

PNMA1
Paraneoplastic antigen Ma1

2

2

High-throughput

0.606

High

1066047

TRI54
Tripartite motif-containing protein 54

2

10

High-throughput

0.606

High

904578

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

982027

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

985543

Q05BL1
TP53BP2 protein

1

8

High-throughput

0.594

High

1066027

RHG44
Rho GTPase-activating protein 44

2

9

High-throughput

0.594

High

400072

ICAM1
Intercellular adhesion molecule 1

2

3

High-throughput

0.574

High

1066052

MED4
Mediator of RNA polymerase II transcription subunit 4

2

2

High-throughput

0.574

High

935777

HBB
Hemoglobin subunit beta

2

2

High-throughput

0.571

High

936040

HBA
Hemoglobin subunit alpha

2

2

High-throughput

0.571

High

1066055

SLAI2
SLAIN motif-containing protein 2

2

1

High-throughput

0.571

High

944029

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.553

High

994881

GOGA2
Golgin subfamily A member 2

2

6

High-throughput

0.553

High

564535

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

1066044

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1066050

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

670834

PRDX5
Peroxiredoxin-5, mitochondrial

2

0

High-throughput

0.547

High

801701

RAGP1
Ran GTPase-activating protein 1

2

0

High-throughput

0.547

High

245979

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.536

High

1066035

NT5D3
5'-nucleotidase domain-containing protein 3

1

1

High-throughput

0.536

High

1066049

RBM38
RNA-binding protein 38

1

3

High-throughput

0.536

High

60579

VP37C
Vacuolar protein sorting-associated protein 37C

2

1

High-throughput

0.521

High

531835

PDIA4
Protein disulfide-isomerase A4

2

5

High-throughput

0.521

High

782243

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.515

High

685959

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

1034751

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

6

Small-scale

0.512

High

1066042

GASP2
G-protein coupled receptor-associated sorting protein 2

1

1

High-throughput

0.508

High

1066058

IKZF3
Zinc finger protein Aiolos

1

0

High-throughput

0.493

High

1066029

TM154
Transmembrane protein 154

1

1

High-throughput

0.489

High

150574

ABLM1
Actin-binding LIM protein 1

1

10

High-throughput

0.479

High

423234

PDIA1
Protein disulfide-isomerase

1

6

High-throughput

0.479

High

610407

CBL
E3 ubiquitin-protein ligase CBL

1

19

Small-scale

0.479

High

670955

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

1

High-throughput

0.479

High

790782

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

11

High-throughput

0.479

High

944253

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

Small-scale

0.479

High

969707

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

1066034

PABP2
Polyadenylate-binding protein 2

1

5

High-throughput

0.479

High

1066036

NUTM1
NUT family member 1

1

0

High-throughput

0.460

High

675047

KPYR
Pyruvate kinase PKLR

1

0

Small-scale

0.458

High

813482

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

962788

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High

941693

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

2

Small-scale

0.457

High

1066043

SPTCS
Spatacsin

1

1

Small-scale

0.457

High

708916

MCM7
DNA replication licensing factor MCM7

1

6

Small-scale

0.445

High

981251

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.437

High

1066048

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.437

High

1066038

ARF
Tumor suppressor ARF

1

0

High-throughput

0.426

High

1066059

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.407

High

1066056

RWD2A
RWD domain-containing protein 2A

2

0

High-throughput

0.316

High

1066030

TM108
Transmembrane protein 108

1

0

High-throughput

0.265

Low

1066057

ZN580
Zinc finger protein 580

1

0

High-throughput

0.265

Low

253980

MTG16
Protein CBFA2T3

1

0

High-throughput

0.251

Low

1066037

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

825043

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024