Protein: DEFI8
Differentially expressed in FDCP 8 homolog (DEF-8)

Gene: DEFI8, DEF8
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q6ZN54

Gene Ontology (top 5):
GO:0008270 - zinc ion binding
GO:0032418 - lysosome localization
GO:0045780 - positive regulation of bone resorption
GO:1900029 - positive regulation of ruffle assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157525

PKN2
Serine/threonine-protein kinase N2

2

19

High-throughput

0.726

High

1243008

PKN3
Serine/threonine-protein kinase N3

2

16

High-throughput

0.726

High

1251216

DUSTY
Dual serine/threonine and tyrosine protein kinase

2

6

High-throughput

0.726

High

1252599

PASK
PAS domain-containing serine/threonine-protein kinase

2

9

High-throughput

0.726

High

1252607

E2AK4
eIF-2-alpha kinase GCN2

2

3

High-throughput

0.726

High

1252587

PKHM3
Pleckstrin homology domain-containing family M member 3

1

3

High-throughput

0.691

High

1252593

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

8

High-throughput

0.691

High

901328

RAB7A
Ras-related protein Rab-7a

2

6

Small-scale

0.675

High

833743

KDM5C
Lysine-specific demethylase 5C

2

1

High-throughput

0.628

High

1252588

WDFY3
WD repeat and FYVE domain-containing protein 3

2

1

High-throughput

0.628

High

343606

OXSR1
Serine/threonine-protein kinase OSR1

1

12

High-throughput

0.618

High

1252589

ZN417
Zinc finger protein 417

2

1

High-throughput

0.606

High

1252600

ZN587
Zinc finger protein 587

2

1

High-throughput

0.606

High

345190

ZMYM6
Zinc finger MYM-type protein 6

2

0

High-throughput

0.602

High

650247

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.594

High

155859

DPYL4
Dihydropyrimidinase-related protein 4

2

1

High-throughput

0.574

High

161728

APAF
Apoptotic protease-activating factor 1

2

5

High-throughput

0.574

High

229537

NRDC
Nardilysin

2

1

High-throughput

0.574

High

1151557

TRIP6
Thyroid receptor-interacting protein 6

2

12

High-throughput

0.574

High

1252590

ALMS1
Centrosome-associated protein ALMS1

2

1

High-throughput

0.574

High

1252591

DMXL2
DmX-like protein 2

2

5

High-throughput

0.574

High

1252598

RADIL
Ras-associating and dilute domain-containing protein

2

6

High-throughput

0.574

High

1252604

IF122
Intraflagellar transport protein 122 homolog

2

3

High-throughput

0.574

High

1252605

PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

2

2

High-throughput

0.574

High

1252609

MCM8
DNA helicase MCM8

2

1

High-throughput

0.574

High

1252608

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.513

High

563958

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.494

High

916673

PPP5
Serine/threonine-protein phosphatase 5

1

3

High-throughput

0.489

High

1108576

TBB3
Tubulin beta-3 chain

1

4

High-throughput

0.489

High

1252594

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.489

High

1252606

DTL
Denticleless protein homolog

1

4

High-throughput

0.489

High

1252610

TBE
Tubulin epsilon chain

1

6

High-throughput

0.489

High

1252596

TRI63
E3 ubiquitin-protein ligase TRIM63

1

7

High-throughput

0.481

High

1252603

TRI55
Tripartite motif-containing protein 55

1

7

High-throughput

0.481

High

242056

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

1252612

PKHM1
Pleckstrin homology domain-containing family M member 1

1

4

Small-scale

0.479

High

1133889

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

11

High-throughput

0.470

High

1232421

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

445009

S10A9
Protein S100-A9

1

1

Small-scale

0.457

High

893961

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

1113474

CUL3
Cullin-3

1

2

High-throughput

0.437

High

1208364

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

8

High-throughput

0.437

High

1056807

FMR1
Fragile X messenger ribonucleoprotein 1

1

9

High-throughput

0.417

High

369357

A1AT
Alpha-1-antitrypsin

1

5

High-throughput

0.407

High

787666

SPB5
Serpin B5

1

6

High-throughput

0.407

High

213618

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

2

0

High-throughput

0.328

High

938657

ALR
FAD-linked sulfhydryl oxidase ALR

2

0

High-throughput

0.328

High

1149311

STIL
SCL-interrupting locus protein

2

0

High-throughput

0.328

High

1231261

BLT3A
Bridge-like lipid transfer protein family member 3A

2

0

High-throughput

0.328

High

1252597

ATG2B
Autophagy-related protein 2 homolog B

2

0

High-throughput

0.328

High

1252601

MSTO1
Protein misato homolog 1

2

0

High-throughput

0.328

High

1252611

HPS5
BLOC-2 complex member HPS5

2

0

High-throughput

0.328

High

1252595

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.282

High

298605

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.279

Low

1193585

CE022
UPF0489 protein C5orf22

1

0

High-throughput

0.279

Low

1206981

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

High-throughput

0.279

Low

892112

KLK7
Kallikrein-7

1

0

High-throughput

0.232

Low

1252592

POF1B
Protein POF1B

1

0

High-throughput

0.232

Low

1252602

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025