Protein: KRIT1
Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)

Gene: KRIT1
Organism: Homo sapiens
Interactions: 40
UniProt ID: O00522

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0003158 - endothelium development
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

139111

ITBP1
Integrin beta-1-binding protein 1

7

0

Small-scale

0.923

High

139138

CCM2
Cerebral cavernous malformations 2 protein

11

1

Small-scale

0.761

High

139140

TLRN1
Talin rod domain-containing protein 1

2

1

High-throughput

0.694

High

139147

HEG1
Protein HEG homolog 1

3

10

Small-scale

0.687

High

139112

NPT2B
Sodium-dependent phosphate transport protein 2B

2

1

High-throughput

0.628

High

139131

TEBP
Prostaglandin E synthase 3

2

2

High-throughput

0.628

High

139126

RAP1A
Ras-related protein Rap-1A

1

20

Small-scale

0.621

High

126356

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

139113

RASK
GTPase KRas

1

20

High-throughput

0.618

High

139114

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

139115

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

139118

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

139122

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

139124

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.618

High

139125

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

139127

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

139132

RAB35
Ras-related protein Rab-35

1

7

High-throughput

0.618

High

139141

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

139144

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

139120

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

4

High-throughput

0.606

High

139121

RAP1B
Ras-related protein Rap-1b

1

20

Small-scale

0.575

High

139128

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

3

Small-scale

0.561

High

139119

RAB2A
Ras-related protein Rab-2A

1

5

High-throughput

0.553

High

139129

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

7

High-throughput

0.541

High

139130

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

1

High-throughput

0.536

High

139142

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

14

High-throughput

0.536

High

139136

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

Small-scale

0.529

High

139116

RGS4
Regulator of G-protein signaling 4

1

3

Small-scale

0.501

High

139117

DAPK1
Death-associated protein kinase 1

1

17

Small-scale

0.479

High

139123

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

139133

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

139134

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

2

Small-scale

0.479

High

139145

PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

1

3

Small-scale

0.479

High

139148

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.479

High

139135

SNIP1
Smad nuclear-interacting protein 1

1

1

Small-scale

0.437

High

139137

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

4

Small-scale

0.437

High

139139

PDC10
Programmed cell death protein 10

1

0

Small-scale

0.426

High

139146

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.426

High

139143

TRPV4
Transient receptor potential cation channel subfamily V member 4

1

6

Small-scale

0.408

High

139110

UBFD1
Ubiquitin domain-containing protein UBFD1

2

0

High-throughput

0.328

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025