Protein: PPR21
Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (Ferry endosomal RAB5 effector complex subunit 2) (Fy-2) (KLRAQ motif-containing protein 1)

Gene: PPR21, PPP1R21
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q6ZMI0

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005769 - early endosome
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1251844

FERY3
Ferry endosomal RAB5 effector complex subunit 3

2

0

High-throughput

0.602

High

348281

QORL1
Quinone oxidoreductase-like protein 1

2

0

High-throughput

0.585

High

1199989

KLH26
Kelch-like protein 26

2

1

High-throughput

0.574

High

1247791

KLH24
Kelch-like protein 24

2

1

High-throughput

0.574

High

1251825

KBTB6
Kelch repeat and BTB domain-containing protein 6

2

2

High-throughput

0.574

High

1251833

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

3

High-throughput

0.574

High

1251837

BTBD9
BTB/POZ domain-containing protein 9

2

2

High-throughput

0.574

High

691779

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.536

High

703627

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.536

High

994269

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

High-throughput

0.536

High

563955

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

1251851

SHLB1
Endophilin-B1

1

1

High-throughput

0.515

High

814540

FEN1
Flap endonuclease 1

1

0

High-throughput

0.513

High

821128

TXLNA
Alpha-taxilin

1

0

High-throughput

0.513

High

932893

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.513

High

1057187

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.513

High

1251830

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

1

0

High-throughput

0.513

High

1251832

TBCK
TBC domain-containing protein kinase-like protein

1

0

High-throughput

0.513

High

1251842

RABE2
Rab GTPase-binding effector protein 2

1

0

High-throughput

0.513

High

1251845

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

0

High-throughput

0.513

High

1251855

PCDBB
Protocadherin beta-11

1

0

High-throughput

0.513

High

1251838

SH3G2
Endophilin-A1

1

1

High-throughput

0.508

High

717511

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.493

High

47354

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.493

High

216725

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

280675

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.493

High

562157

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

843687

HD
Huntingtin

1

0

High-throughput

0.493

High

856757

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.493

High

927366

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

981555

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.493

High

1096059

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

1251834

JPH3
Junctophilin-3

1

0

High-throughput

0.493

High

318499

TOX4
TOX high mobility group box family member 4

1

1

High-throughput

0.489

High

1112887

CUL2
Cullin-2

1

1

High-throughput

0.489

High

560429

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

631300

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

942694

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

1251823

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

967811

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

Small-scale

0.457

High

529986

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

1031426

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1114906

CUL4A
Cullin-4A

1

1

High-throughput

0.437

High

1210881

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.437

High

934768

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

1251829

WDTC1
WD and tetratricopeptide repeats protein 1

3

0

High-throughput

0.345

High

1251831

TCP1L
T-complex protein 10A homolog 1

3

0

High-throughput

0.345

High

477104

IL6RA
Interleukin-6 receptor subunit alpha

2

0

High-throughput

0.328

High

771546

TSP2
Thrombospondin-2

2

0

High-throughput

0.328

High

1251828

FXL14
F-box/LRR-repeat protein 14

2

0

High-throughput

0.328

High

1251841

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

2

0

High-throughput

0.328

High

1251843

SH22A
SH2 domain-containing protein 2A

2

0

High-throughput

0.310

High

1251827

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

161482

KMT2D
Histone-lysine N-methyltransferase 2D

1

0

High-throughput

0.279

Low

249867

STX10
Syntaxin-10

1

0

High-throughput

0.279

Low

709133

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.279

Low

892040

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.279

Low

1024316

METK1
S-adenosylmethionine synthase isoform type-1

1

0

High-throughput

0.279

Low

1041450

ACY1
Aminoacylase-1

1

0

High-throughput

0.279

Low

1098218

MYBPH
Myosin-binding protein H

1

0

High-throughput

0.279

Low

1215461

CE162
Centrosomal protein of 162 kDa

1

0

High-throughput

0.279

Low

1234592

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.279

Low

1251826

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

0

High-throughput

0.279

Low

1251840

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.279

Low

1251847

RN181
E3 ubiquitin-protein ligase RNF181

1

0

High-throughput

0.279

Low

1251848

IMPCT
Protein IMPACT

1

0

High-throughput

0.279

Low

1251850

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.279

Low

1251852

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.279

Low

159981

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.268

Low

167297

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.268

Low

361703

F13A
Coagulation factor XIII A chain

1

0

High-throughput

0.268

Low

384460

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.268

Low

441550

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

442372

GELS
Gelsolin

1

0

High-throughput

0.268

Low

570466

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.268

Low

622194

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

650246

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

713108

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.268

Low

937042

CASP6
Caspase-6

1

0

High-throughput

0.268

Low

1023562

CYC
Cytochrome c

1

0

High-throughput

0.268

Low

1133888

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

1251824

Q86V38
Atrophin 1

1

0

High-throughput

0.268

Low

1251836

KLK6
Kallikrein-6

1

0

High-throughput

0.268

Low

1251839

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

880933

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

1251853

FBX7
F-box only protein 7

1

0

High-throughput

0.261

Low

106139

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

218359

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

1181249

ZN750
Zinc finger protein 750

1

0

Small-scale

0.249

Low

1240741

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.249

Low

1251822

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1251835

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.249

Low

1251849

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1251854

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1251846

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

116526

H7C417
CRAL-TRIO domain-containing protein

1

0

High-throughput

0.232

Low

127113

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.232

Low

1167066

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025