Protein: FANCL
E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL)

Gene: FANCL
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q9NW38

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1446242

UBE2T
Ubiquitin-conjugating enzyme E2 T

15

0

Small-scale

0.935

High

1383938

UBE2W
Ubiquitin-conjugating enzyme E2 W

3

2

Small-scale

0.840

High

1451053

FANCL
E3 ubiquitin-protein ligase FANCL

2

1

Small-scale

0.768

High

1417497

FACD2
Fanconi anemia group D2 protein

13

2

Small-scale

0.760

High

1450550

FANCI
Fanconi anemia group I protein

8

3

Small-scale

0.745

High

187568

FANCA
Fanconi anemia group A protein

15

0

Small-scale

0.727

High

1314878

FANCM
Fanconi anemia group M protein

10

0

Small-scale

0.718

High

185244

FANCG
Fanconi anemia group G protein

5

1

Small-scale

0.702

High

1081784

FP100
Fanconi anemia core complex-associated protein 100

4

0

Small-scale

0.663

High

1451054

MIC19
MICOS complex subunit MIC19

3

0

High-throughput

0.646

High

1333226

FANCB
Fanconi anemia group B protein

3

0

Small-scale

0.630

High

1446505

FANCF
Fanconi anemia group F protein

3

0

Small-scale

0.619

High

1025903

FANCC
Fanconi anemia group C protein

3

0

Small-scale

0.613

High

478302

HXD4
Homeobox protein Hox-D4

2

1

High-throughput

0.606

High

551289

PCNA
Proliferating cell nuclear antigen

2

0

Small-scale

0.603

High

590503

GATA1
Erythroid transcription factor

2

0

High-throughput

0.580

High

1036553

ID2
DNA-binding protein inhibitor ID-2

2

0

High-throughput

0.580

High

1186865

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.580

High

1198054

KR132
Keratin-associated protein 13-2

2

0

High-throughput

0.580

High

1231247

NB5R2
NADH-cytochrome b5 reductase 2

2

0

High-throughput

0.580

High

1238975

UFSP1
Ufm1-specific protease 1

2

0

High-throughput

0.580

High

1244226

MORN3
MORN repeat-containing protein 3

2

0

High-throughput

0.580

High

1307069

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.580

High

1392623

SNF8
Vacuolar-sorting protein SNF8

2

0

High-throughput

0.580

High

1412500

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

2

0

High-throughput

0.580

High

1416182

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.580

High

1428919

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

2

0

High-throughput

0.580

High

1451056

ZN581
Zinc finger protein 581

2

0

High-throughput

0.580

High

1451064

RNF11
RING finger protein 11

2

0

High-throughput

0.580

High

70881

CENPX
Centromere protein X

2

0

Small-scale

0.559

High

1239793

FAP20
Fanconi anemia core complex-associated protein 20

2

0

Small-scale

0.559

High

1086327

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.549

High

1307527

RBM45
RNA-binding protein 45

1

0

High-throughput

0.549

High

1338520

DOCK8
Dedicator of cytokinesis protein 8

1

0

High-throughput

0.549

High

1411336

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.549

High

1448107

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.549

High

1451058

RIM3A
RIMS-binding protein 3A

1

0

High-throughput

0.549

High

1451060

IKZF3
Zinc finger protein Aiolos

1

0

High-throughput

0.549

High

1451063

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.549

High

1126806

HES1
Transcription factor HES-1

1

0

Small-scale

0.529

High

1360351

ATRIP
ATR-interacting protein

1

0

Small-scale

0.529

High

192870

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

621990

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

1023628

CYC
Cytochrome c

1

0

High-throughput

0.513

High

1148880

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

0

High-throughput

0.513

High

1413600

FAP24
Fanconi anemia core complex-associated protein 24

1

0

Small-scale

0.513

High

213378

ARHG9
Rho guanine nucleotide exchange factor 9

1

0

High-throughput

0.493

High

887597

PSB3
Proteasome subunit beta type-3

1

0

High-throughput

0.493

High

1239213

ZN774
Zinc finger protein 774

1

0

High-throughput

0.493

High

1451055

ZN224
Zinc finger protein 224

1

0

High-throughput

0.493

High

1451057

ZMAT5
Zinc finger matrin-type protein 5

1

0

High-throughput

0.493

High

1451062

SNX7
Sorting nexin-7

1

1

High-throughput

0.489

High

1106720

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.484

High

1451061

CAPS1
Calcium-dependent secretion activator 1

1

1

High-throughput

0.481

High

1451065

SNX11
Sorting nexin-11

1

1

High-throughput

0.470

High

60256

A2RRN7
CADPS protein

1

1

High-throughput

0.470

High

1103407

CTBP1
C-terminal-binding protein 1

1

0

Small-scale

0.460

High

578556

BRAF
Serine/threonine-protein kinase B-raf

1

0

High-throughput

0.458

High

799515

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

856949

BAG6
Large proline-rich protein BAG6

1

0

Small-scale

0.458

High

1324642

CENPS
Centromere protein S

1

0

Small-scale

0.458

High

1415242

KIFC3
Kinesin-like protein KIFC3

3

0

High-throughput

0.352

High

477113

IL6RA
Interleukin-6 receptor subunit alpha

2

0

High-throughput

0.328

High

1293920

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

0

High-throughput

0.328

High

1451059

CLC2D
C-type lectin domain family 2 member D

2

0

High-throughput

0.328

High

66312

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

2

0

High-throughput

0.316

High

350309

DDAH2
Putative hydrolase DDAH2

2

0

High-throughput

0.316

High

1203505

ACTMP
Actin maturation protease

2

0

High-throughput

0.316

High

1212702

GT253
Inactive glycosyltransferase 25 family member 3

2

0

High-throughput

0.316

High

1410560

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

2

0

High-throughput

0.316

High

705578

GRN
Progranulin

1

0

High-throughput

0.299

High

1314617

IHO1
Interactor of HORMAD1 protein 1

1

0

High-throughput

0.299

High

1340029

GP150
Probable G-protein coupled receptor 150

1

0

High-throughput

0.279

Low

70506

CRTP1
Cysteine-rich tail protein 1

1

0

High-throughput

0.268

Low

1186151

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.268

Low

1220053

TTC23
Tetratricopeptide repeat protein 23

1

0

High-throughput

0.268

Low

1312910

Q8IXS7
SRGAP3 protein

1

0

High-throughput

0.268

Low

959539

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025