Protein: GRDN
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)

Gene: GRDN, CCDC88A
Organism: Homo sapiens
Interactions: 224
UniProt ID: Q3V6T2

Gene Ontology (top 5):
GO:0001965 - G-protein alpha-subunit binding
GO:0003779 - actin binding
GO:0005080 - protein kinase C binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005092 - GDP-dissociation inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982073

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

444740

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

4

7

Small-scale

0.700

High

683394

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

904637

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

259943

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

4

High-throughput

0.667

High

429901

CATL1
Procathepsin L

3

3

High-throughput

0.667

High

909625

1433E
14-3-3 protein epsilon

3

7

High-throughput

0.667

High

681881

AKT1
RAC-alpha serine/threonine-protein kinase

2

20

Small-scale

0.643

High

885538

MLF1
Myeloid leukemia factor 1

3

0

High-throughput

0.638

High

299261

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

2

12

High-throughput

0.628

High

1031210

SKP2
S-phase kinase-associated protein 2

2

2

High-throughput

0.628

High

1113815

RPGF5
Rap guanine nucleotide exchange factor 5

2

1

High-throughput

0.628

High

338508

EGFR
Epidermal growth factor receptor

2

11

Small-scale

0.624

High

1113782

GRDN
Girdin

1

19

Small-scale

0.618

High

1113802

HOOK3
Protein Hook homolog 3

1

16

High-throughput

0.618

High

319864

HERC2
E3 ubiquitin-protein ligase HERC2

2

11

High-throughput

0.611

High

391407

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

7

High-throughput

0.611

High

646944

1433T
14-3-3 protein theta

2

20

High-throughput

0.611

High

795634

MAGA1
Melanoma-associated antigen 1

2

12

High-throughput

0.611

High

927105

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1113813

PARD3
Partitioning defective 3 homolog

2

15

High-throughput

0.611

High

1113855

JADE2
E3 ubiquitin-protein ligase Jade-2

3

2

High-throughput

0.609

High

1113783

RFTN2
Raftlin-2

2

0

High-throughput

0.602

High

1113843

NDEL1
Nuclear distribution protein nudE-like 1

2

15

High-throughput

0.590

High

1113856

DISC1
Disrupted in schizophrenia 1 protein

2

5

High-throughput

0.590

High

1113784

TFDP3
Transcription factor Dp family member 3

2

0

High-throughput

0.585

High

325758

LATS1
Serine/threonine-protein kinase LATS1

2

20

High-throughput

0.584

High

350211

RASK
GTPase KRas

2

20

High-throughput

0.584

High

567083

CXA1
Gap junction alpha-1 protein

2

7

Small-scale

0.584

High

577027

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

3

High-throughput

0.584

High

914103

RB11A
Ras-related protein Rab-11A

2

5

High-throughput

0.584

High

915716

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

665897

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

3

Small-scale

0.578

High

1113857

EXOC1
Exocyst complex component 1

2

1

High-throughput

0.576

High

1113828

CC136
Coiled-coil domain-containing protein 136

2

16

High-throughput

0.574

High

411404

INSR
Insulin receptor

1

20

Small-scale

0.561

High

542888

BRAF
Serine/threonine-protein kinase B-raf

1

11

High-throughput

0.541

High

568689

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

18

High-throughput

0.541

High

177316

HDAC3
Histone deacetylase 3

1

20

High-throughput

0.536

High

201943

WDR62
WD repeat-containing protein 62

1

15

High-throughput

0.536

High

302292

SC31A
Protein transport protein Sec31A

1

18

High-throughput

0.536

High

376251

ANXA1
Annexin A1

1

9

High-throughput

0.536

High

383838

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

9

High-throughput

0.536

High

416633

S10A6
Protein S100-A6

1

20

High-throughput

0.536

High

638971

S100P
Protein S100-P

1

20

High-throughput

0.536

High

675177

CLIP1
CAP-Gly domain-containing linker protein 1

1

16

High-throughput

0.536

High

740161

NUP62
Nuclear pore glycoprotein p62

1

12

High-throughput

0.536

High

781554

CETN2
Centrin-2

1

2

High-throughput

0.536

High

803562

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.536

High

821772

NEST
Nestin

1

19

High-throughput

0.536

High

851522

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.536

High

862295

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

1

High-throughput

0.536

High

881734

PER3
Period circadian protein homolog 3

1

10

High-throughput

0.536

High

919096

RAN
GTP-binding nuclear protein Ran

1

12

High-throughput

0.536

High

1029246

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

1053709

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

1

High-throughput

0.536

High

1056418

IRF3
Interferon regulatory factor 3

1

3

High-throughput

0.536

High

1058440

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.536

High

1070824

RCN1
Reticulocalbin-1

1

10

High-throughput

0.536

High

1076956

MARE1
Microtubule-associated protein RP/EB family member 1

1

7

High-throughput

0.536

High

1113819

CELF1
CUGBP Elav-like family member 1

1

6

High-throughput

0.536

High

1113823

TRI52
E3 ubiquitin-protein ligase TRIM52

1

8

High-throughput

0.536

High

1113827

FUBP3
Far upstream element-binding protein 3

1

10

High-throughput

0.536

High

1113837

SRSF8
Serine/arginine-rich splicing factor 8

1

9

High-throughput

0.536

High

1113840

RBM4
RNA-binding protein 4

1

13

High-throughput

0.536

High

1113841

DUS16
Dual specificity protein phosphatase 16

1

13

High-throughput

0.536

High

1113842

BACH2
Transcription regulator protein BACH2

1

9

High-throughput

0.536

High

1113849

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1113854

DLRB1
Dynein light chain roadblock-type 1

1

1

High-throughput

0.536

High

1113863

CYH4
Cytohesin-4

1

2

High-throughput

0.536

High

154608

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.513

High

519003

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

537924

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.513

High

1101705

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

1113797

BRNP3
BMP/retinoic acid-inducible neural-specific protein 3

1

0

High-throughput

0.513

High

1113804

BBS7
Bardet-Biedl syndrome 7 protein

1

0

High-throughput

0.513

High

1113826

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

1113838

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.513

High

1113870

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

729660

VGFR2
Vascular endothelial growth factor receptor 2

1

5

Small-scale

0.501

High

674448

UFO
Tyrosine-protein kinase receptor UFO

1

13

High-throughput

0.500

High

661274

S10A2
Protein S100-A2

1

20

High-throughput

0.489

High

1113785

CF141
Uncharacterized protein C6orf141

1

1

High-throughput

0.489

High

1113786

RBM26
RNA-binding protein 26

1

9

High-throughput

0.489

High

1113809

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

17

High-throughput

0.489

High

1113832

IWS1
Protein IWS1 homolog

1

6

High-throughput

0.489

High

116581

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

1

High-throughput

0.479

High

120469

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

162808

XPO1
Exportin-1

1

7

High-throughput

0.479

High

164130

ARHGA
Rho guanine nucleotide exchange factor 10

1

15

High-throughput

0.479

High

178563

STX7
Syntaxin-7

1

4

High-throughput

0.479

High

212850

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

227627

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

232898

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

12

High-throughput

0.479

High

279577

FLOT1
Flotillin-1

1

5

High-throughput

0.479

High

305472

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.479

High

315714

SC24B
Protein transport protein Sec24B

1

1

High-throughput

0.479

High

318148

DIRA3
GTP-binding protein Di-Ras3

1

11

High-throughput

0.479

High

318634

EYA4
Eyes absent homolog 4

1

3

High-throughput

0.479

High

348699

RASN
GTPase NRas

1

19

High-throughput

0.479

High

384941

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.479

High

411743

LCK
Tyrosine-protein kinase Lck

1

14

High-throughput

0.479

High

433795

LYN
Tyrosine-protein kinase Lyn

1

14

High-throughput

0.479

High

436338

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

507043

LAMP1
Lysosome-associated membrane glycoprotein 1

1

6

High-throughput

0.479

High

508036

FGFR1
Fibroblast growth factor receptor 1

1

17

High-throughput

0.479

High

545414

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

564553

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

589199

ANXA7
Annexin A7

1

9

High-throughput

0.479

High

600585

EPHA1
Ephrin type-A receptor 1

1

5

High-throughput

0.479

High

601523

FGFR2
Fibroblast growth factor receptor 2

1

17

High-throughput

0.479

High

666610

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.479

High

670051

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

684075

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

716699

CTNA1
Catenin alpha-1

1

4

High-throughput

0.479

High

717133

CTNB1
Catenin beta-1

1

11

High-throughput

0.479

High

726862

FUS
RNA-binding protein FUS

1

9

High-throughput

0.479

High

740537

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

768435

CAPG
Macrophage-capping protein

1

14

High-throughput

0.479

High

793340

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

803929

NSF
Vesicle-fusing ATPase

1

7

High-throughput

0.479

High

835390

GSK3A
Glycogen synthase kinase-3 alpha

1

16

High-throughput

0.479

High

835802

GSK3B
Glycogen synthase kinase-3 beta

1

19

High-throughput

0.479

High

852504

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

876402

AFAD
Afadin

1

20

High-throughput

0.479

High

892403

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

894079

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

895105

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.479

High

900534

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

901171

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

908642

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

912933

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

919740

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

1

High-throughput

0.479

High

921592

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

15

High-throughput

0.479

High

925322

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

925885

AP2B1
AP-2 complex subunit beta

1

9

High-throughput

0.479

High

940440

CXAR
Coxsackievirus and adenovirus receptor

1

4

High-throughput

0.479

High

951040

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

972972

RASF7
Ras association domain-containing protein 7

1

2

High-throughput

0.479

High

974849

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1017651

STX4
Syntaxin-4

1

4

High-throughput

0.479

High

1022111

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.479

High

1051301

DCTN1
Dynactin subunit 1

1

20

High-throughput

0.479

High

1051558

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

6

High-throughput

0.479

High

1068548

PLEC
Plectin

1

20

High-throughput

0.479

High

1070216

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.479

High

1076602

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1083267

RBBP7
Histone-binding protein RBBP7

1

18

High-throughput

0.479

High

1083852

NTRK2
BDNF/NT-3 growth factors receptor

1

19

High-throughput

0.479

High

1101650

AAK1
AP2-associated protein kinase 1

1

17

High-throughput

0.479

High

1113788

MT21C
Protein-lysine methyltransferase METTL21C

1

10

High-throughput

0.479

High

1113789

CP135
Centrosomal protein of 135 kDa

1

17

High-throughput

0.479

High

1113790

A16L1
Autophagy-related protein 16-1

1

16

High-throughput

0.479

High

1113791

RNF43
E3 ubiquitin-protein ligase RNF43

1

9

High-throughput

0.479

High

1113792

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1113794

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.479

High

1113796

MOB2
MOB kinase activator 2

1

6

High-throughput

0.479

High

1113798

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1113801

LUZP1
Leucine zipper protein 1

1

18

High-throughput

0.479

High

1113806

CXD3
Gap junction delta-3 protein

1

7

High-throughput

0.479

High

1113808

WDTC1
WD and tetratricopeptide repeats protein 1

1

20

High-throughput

0.479

High

1113810

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1113811

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.479

High

1113814

MT21A
Protein N-lysine methyltransferase METTL21A

1

10

High-throughput

0.479

High

1113816

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

20

High-throughput

0.479

High

1113817

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1113818

KAT6A
Histone acetyltransferase KAT6A

1

15

High-throughput

0.479

High

1113820

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

18

High-throughput

0.479

High

1113829

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1113831

FMNL2
Formin-like protein 2

1

5

High-throughput

0.479

High

1113833

NUP88
Nuclear pore complex protein Nup88

1

1

High-throughput

0.479

High

1113834

BARD1
BRCA1-associated RING domain protein 1

1

8

High-throughput

0.479

High

1113835

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.479

High

1113836

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

1113839

CP250
Centrosome-associated protein CEP250

1

17

High-throughput

0.479

High

1113845

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

9

Small-scale

0.479

High

1113846

VP33B
Vacuolar protein sorting-associated protein 33B

1

2

High-throughput

0.479

High

1113847

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.479

High

1113848

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1113850

MOB1A
MOB kinase activator 1A

1

6

High-throughput

0.479

High

1113851

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1113852

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

9

High-throughput

0.479

High

1113853

E41LA
Band 4.1-like protein 4A

1

14

High-throughput

0.479

High

1113861

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

9

High-throughput

0.479

High

1113862

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1113865

MARE3
Microtubule-associated protein RP/EB family member 3

1

7

High-throughput

0.479

High

1113866

PHOCN
MOB-like protein phocein

1

6

High-throughput

0.479

High

1113867

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

5

High-throughput

0.479

High

1113868

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

2

Small-scale

0.479

High

1113869

SAR1B
Small COPII coat GTPase SAR1B

1

7

High-throughput

0.479

High

201023

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.458

High

1084024

OCLN
Occludin

1

0

High-throughput

0.458

High

1113787

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

1113800

PEG10
Retrotransposon-derived protein PEG10

1

0

Small-scale

0.458

High

1113803

DEN6A
Protein DENND6A

1

0

High-throughput

0.458

High

1113812

URGCP
Up-regulator of cell proliferation

1

0

High-throughput

0.458

High

1113858

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.458

High

791618

HD
Huntingtin

1

4

High-throughput

0.457

High

988920

FMR1
Fragile X messenger ribonucleoprotein 1

1

11

High-throughput

0.457

High

1113844

PRD14
PR domain zinc finger protein 14

1

4

Small-scale

0.457

High

72998

B4DT77
Annexin

1

9

High-throughput

0.445

High

73016

B4DU58
cDNA FLJ51488, highly similar to Macrophage capping protein

1

14

High-throughput

0.445

High

111067

I3L0N3
Vesicle-fusing ATPase

1

7

High-throughput

0.445

High

120937

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

High-throughput

0.445

High

717891

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.445

High

1113805

CNTRB
Centrobin

1

16

High-throughput

0.445

High

1113807

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.445

High

1113830

CEP63
Centrosomal protein of 63 kDa

1

17

High-throughput

0.445

High

1113859

PIHD1
PIH1 domain-containing protein 1

1

4

Small-scale

0.445

High

232199

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.437

High

1101044

QSER1
Glutamine and serine-rich protein 1

1

7

High-throughput

0.437

High

1113793

FBX42
F-box only protein 42

1

16

High-throughput

0.437

High

1113795

PAXI1
PAX-interacting protein 1

1

13

High-throughput

0.437

High

1113799

DET1
DET1 homolog

1

2

High-throughput

0.437

High

1113821

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

19

High-throughput

0.437

High

1113825

PF21A
PHD finger protein 21A

1

20

High-throughput

0.437

High

1113860

SEP10
Septin-10

1

4

High-throughput

0.437

High

1113864

RCOR1
REST corepressor 1

1

7

High-throughput

0.437

High

854425

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.279

Low

1113824

EME1
Crossover junction endonuclease EME1

1

0

High-throughput

0.279

Low

203452

MTG8R
Protein CBFA2T2

1

0

Small-scale

0.261

Low

81721

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

Small-scale

0.249

Low

1113822

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024