Protein: G6PI
Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36)

Gene: G6PI, GPI
Organism: Homo sapiens
Interactions: 154
UniProt ID: P06744

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0001707 - mesoderm formation
GO:0002639 - positive regulation of immunoglobulin production
GO:0004347 - glucose-6-phosphate isomerase activity
GO:0005125 - cytokine activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

240499

PRKN
E3 ubiquitin-protein ligase parkin

3

2

High-throughput

0.640

High

446366

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.628

High

446361

G6PI
Glucose-6-phosphate isomerase

1

3

High-throughput

0.618

High

425254

ISG15
Ubiquitin-like protein ISG15

2

2

High-throughput

0.584

High

352849

AGR2
Anterior gradient protein 2 homolog

2

0

Small-scale

0.576

High

446476

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

Small-scale

0.561

High

446384

RS27
Small ribosomal subunit protein eS27

2

0

High-throughput

0.559

High

446382

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

446461

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.536

High

124569

EYA2
Protein phosphatase EYA2

1

0

High-throughput

0.513

High

186184

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.513

High

446370

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

446387

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

446410

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

446421

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

0

High-throughput

0.513

High

446429

DUS7
Dual specificity protein phosphatase 7

1

0

High-throughput

0.513

High

446448

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

446368

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.501

High

446408

TIE2
Angiopoietin-1 receptor

1

2

High-throughput

0.500

High

155064

SOCS2
Suppressor of cytokine signaling 2

1

0

High-throughput

0.493

High

446412

MERTK
Tyrosine-protein kinase Mer

1

3

High-throughput

0.489

High

446449

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.489

High

446459

LMTK3
Serine/threonine-protein kinase LMTK3

1

3

High-throughput

0.489

High

188783

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

277516

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.479

High

400125

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

446364

MET
Hepatocyte growth factor receptor

1

2

High-throughput

0.479

High

446369

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

446372

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

446377

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

446378

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.479

High

446385

MK08
Mitogen-activated protein kinase 8

1

1

High-throughput

0.479

High

446386

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

446391

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

446400

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

High-throughput

0.479

High

446402

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

446413

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

446417

CUL3
Cullin-3

1

1

High-throughput

0.479

High

446430

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

2

Small-scale

0.479

High

446431

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.479

High

446436

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.479

High

446437

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

446442

RPTOR
Regulatory-associated protein of mTOR

1

2

High-throughput

0.479

High

446465

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.479

High

446471

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

446472

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

446477

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

446479

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

1

High-throughput

0.479

High

169898

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

176125

PER2
Period circadian protein homolog 2

1

0

Small-scale

0.458

High

213040

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

Small-scale

0.458

High

258052

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

271213

CPNE3
Copine-3

1

0

High-throughput

0.458

High

271825

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

279616

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

347468

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

361838

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.458

High

370937

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

411189

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

420302

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

446362

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

446365

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

446367

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

446371

PLST
Plastin-3

1

0

High-throughput

0.458

High

446374

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

446376

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

446383

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

446389

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

446390

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

446395

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

446399

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

446401

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

446404

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.458

High

446411

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

446414

TRAF3
TNF receptor-associated factor 3

1

0

Small-scale

0.458

High

446416

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

446418

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

0

High-throughput

0.458

High

446422

CUL7
Cullin-7

1

0

High-throughput

0.458

High

446423

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

446425

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

446427

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

446428

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

446432

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

446435

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

446438

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

446444

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

446445

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

446446

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

446452

ASB15
Ankyrin repeat and SOCS box protein 15

1

0

High-throughput

0.458

High

446453

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

446455

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

446462

NECD
Necdin

1

0

High-throughput

0.458

High

446463

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.458

High

446464

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

446469

NGB
Neuroglobin

1

0

High-throughput

0.458

High

446470

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.458

High

446473

CRNN
Cornulin

1

0

High-throughput

0.458

High

446474

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

446475

TES
Testin

1

0

High-throughput

0.458

High

446480

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

446482

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.458

High

446483

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

429150

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

446394

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

446396

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

446398

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.445

High

446466

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.445

High

446457

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

259311

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

446363

RU2B
U2 small nuclear ribonucleoprotein B''

1

1

High-throughput

0.437

High

446375

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.437

High

446393

EPHA4
Ephrin type-A receptor 4

1

2

High-throughput

0.437

High

446407

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

446415

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

446426

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.437

High

446451

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

446467

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

446468

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

419948

B3A2
Anion exchange protein 2

1

0

High-throughput

0.426

High

446379

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

446397

NAC3
Sodium/calcium exchanger 3

1

0

High-throughput

0.426

High

446460

ATAD5
ATPase family AAA domain-containing protein 5

3

0

High-throughput

0.334

High

446419

FA50A
Protein FAM50A

2

0

High-throughput

0.305

High

446439

MYLK4
Myosin light chain kinase family member 4

1

0

High-throughput

0.279

Low

446447

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.279

Low

223491

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

0

High-throughput

0.249

Low

239667

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

276037

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

352291

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

446373

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

446380

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

446381

FUS
RNA-binding protein FUS

1

0

High-throughput

0.249

Low

446388

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.249

Low

446392

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.249

Low

446403

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

446405

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

446420

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

446424

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

446433

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

446434

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

446441

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

446443

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

446450

SPRY4
SPRY domain-containing protein 4

1

0

High-throughput

0.249

Low

446454

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

446456

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.249

Low

446458

NEUL4
Neuralized-like protein 4

1

0

Small-scale

0.249

Low

446478

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

446481

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

446484

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.249

Low

446485

RAI2
Retinoic acid-induced protein 2

1

0

High-throughput

0.249

Low

446406

E2F1
Transcription factor E2F1

1

0

High-throughput

0.232

Low

446409

P
P protein

1

0

High-throughput

0.232

Low

446440

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025