Protein: EDF1
Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1)

Gene: EDF1
Organism: Homo sapiens
Interactions: 85
UniProt ID: O60869

Gene Ontology (top 5):
GO:0001094 - TFIID-class transcription factor complex binding
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

258423

TBP
TATA-box-binding protein

3

2

Small-scale

0.663

High

258409

ESR1
Estrogen receptor

3

3

Small-scale

0.641

High

258411

JUN
Transcription factor Jun

2

3

Small-scale

0.624

High

258426

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.618

High

258415

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.576

High

258430

PPARG
Peroxisome proliferator-activated receptor gamma

1

3

Small-scale

0.573

High

258453

NR1H3
Oxysterols receptor LXR-alpha

1

3

Small-scale

0.573

High

258436

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.573

High

258435

CEBPA
CCAAT/enhancer-binding protein alpha

2

1

Small-scale

0.571

High

137518

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

6

Small-scale

0.561

High

258422

RXRA
Retinoic acid receptor RXR-alpha

1

2

Small-scale

0.561

High

258400

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

258449

H31
Histone H3.1

2

0

High-throughput

0.559

High

258427

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.536

High

258417

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

258403

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.513

High

258413

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

258434

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

258444

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

258457

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

258469

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

258478

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.513

High

258480

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

258458

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.508

High

258401

LRP6
Low-density lipoprotein receptor-related protein 6

1

0

High-throughput

0.493

High

258438

ZN157
Zinc finger protein 157

1

0

High-throughput

0.493

High

258452

TF3C1
General transcription factor 3C polypeptide 1

1

0

High-throughput

0.493

High

258479

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.493

High

258432

HD
Huntingtin

1

0

High-throughput

0.493

High

258439

NRL
Neural retina-specific leucine zipper protein

1

0

Small-scale

0.480

High

258442

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

258448

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

258407

FOS
Protein c-Fos

1

1

Small-scale

0.479

High

258419

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

258421

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

1

Small-scale

0.479

High

258454

STF1
Steroidogenic factor 1

1

4

Small-scale

0.479

High

258460

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

258472

NANOG
Homeobox protein NANOG

1

2

High-throughput

0.479

High

258451

SOX4
Transcription factor SOX-4

1

0

Small-scale

0.460

High

131613

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

240247

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

258402

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

258404

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

258405

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

258406

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

258408

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

258410

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

258412

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

258416

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

258418

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

258420

PYRG1
CTP synthase 1

1

0

High-throughput

0.458

High

258424

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

258425

FGFR4
Fibroblast growth factor receptor 4

1

0

High-throughput

0.458

High

258428

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

258429

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

258431

SYUA
Alpha-synuclein

1

0

Small-scale

0.458

High

258433

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

258437

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

258441

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

258445

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

258446

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

258447

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

258450

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

258455

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

258456

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

258459

RC3H1
Roquin-1

1

0

High-throughput

0.458

High

258461

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

258463

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

258464

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

258465

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

258467

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

258468

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

258470

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

258473

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

258474

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

258475

ZO2
Tight junction protein 2

1

0

High-throughput

0.458

High

258476

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

258477

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

258481

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

258414

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.426

High

258440

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

258443

1433G
14-3-3 protein gamma

1

0

High-throughput

0.426

High

258466

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

258471

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

258462

SBSN
Suprabasin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025