Protein: MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)

Gene: MKNK2
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q9HBH9

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158187

MK14
Mitogen-activated protein kinase 14

7

20

Small-scale

0.970

High

703717

MK01
Mitogen-activated protein kinase 1

5

20

Small-scale

0.931

High

856930

BAG6
Large proline-rich protein BAG6

2

11

High-throughput

0.802

High

853740

MK08
Mitogen-activated protein kinase 8

1

20

High-throughput

0.698

High

691853

MK03
Mitogen-activated protein kinase 3

1

20

High-throughput

0.691

High

750479

CSTF2
Cleavage stimulation factor subunit 2

1

1

High-throughput

0.691

High

891318

GSK3A
Glycogen synthase kinase-3 alpha

1

11

High-throughput

0.691

High

891802

GSK3B
Glycogen synthase kinase-3 beta

1

17

High-throughput

0.691

High

1090550

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.691

High

1414070

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

18

High-throughput

0.691

High

1416125

RBM4
RNA-binding protein 4

1

3

High-throughput

0.691

High

822869

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.676

High

167398

KLF11
Krueppel-like factor 11

1

2

High-throughput

0.665

High

1369847

CELF1
CUGBP Elav-like family member 1

1

0

High-throughput

0.656

High

1209678

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.647

High

681038

PSA1
Proteasome subunit alpha type-1

2

2

High-throughput

0.606

High

1438309

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

16

High-throughput

0.590

High

1402593

SRPK1
SRSF protein kinase 1

1

17

High-throughput

0.575

High

1047112

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

7

Small-scale

0.561

High

132308

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.536

High

182372

WDR46
WD repeat-containing protein 46

1

1

High-throughput

0.536

High

409089

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.536

High

570989

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

613466

VINC
Vinculin

1

2

High-throughput

0.536

High

1134541

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

2

High-throughput

0.536

High

1210742

ZMYM1
Zinc finger MYM-type protein 1

1

4

High-throughput

0.536

High

1214671

RBM26
RNA-binding protein 26

1

3

High-throughput

0.536

High

1219433

TUT7
Terminal uridylyltransferase 7

1

2

High-throughput

0.536

High

1247000

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.536

High

1272885

RFIP2
Rab11 family-interacting protein 2

1

6

High-throughput

0.536

High

1287607

ADCK1
AarF domain-containing protein kinase 1

1

1

High-throughput

0.536

High

1322652

RPTOR
Regulatory-associated protein of mTOR

1

7

High-throughput

0.536

High

1370854

FUBP2
Far upstream element-binding protein 2

1

3

High-throughput

0.536

High

975957

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.518

High

228375

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.513

High

1368760

SYMPK
Symplekin

1

0

High-throughput

0.513

High

1421335

BHE41
Class E basic helix-loop-helix protein 41

1

0

High-throughput

0.513

High

1438310

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.513

High

907939

PLXA3
Plexin-A3

1

1

High-throughput

0.489

High

1334134

TXND5
Thioredoxin domain-containing protein 5

1

2

High-throughput

0.489

High

1112992

CUL2
Cullin-2

1

5

Small-scale

0.481

High

1367321

ESR2
Estrogen receptor beta

1

8

Small-scale

0.481

High

1115446

CUL4B
Cullin-4B

1

5

High-throughput

0.479

High

963373

PFD3
Prefoldin subunit 3

1

0

Small-scale

0.460

High

983981

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.460

High

445600

IF4E
Eukaryotic translation initiation factor 4E

1

3

Small-scale

0.445

High

1131233

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

252921

EXOC3
Exocyst complex component 3

1

0

High-throughput

0.279

Low

1307150

TCAM1
TIR domain-containing adapter molecule 1

1

0

High-throughput

0.279

Low

1350297

C99L2
CD99 antigen-like protein 2

1

0

High-throughput

0.279

Low

1388278

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.279

Low

1407817

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025