Protein: EXOC3
Exocyst complex component 3 (Exocyst complex component Sec6)

Gene: EXOC3
Organism: Homo sapiens
Interactions: 152
UniProt ID: O60645

Gene Ontology (top 5):
GO:0000145 - exocyst
GO:0000149 - SNARE binding
GO:0000281 - mitotic cytokinesis
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

252894

EXOC4
Exocyst complex component 4

9

7

Small-scale

0.751

High

137157

EXOC5
Exocyst complex component 5

5

2

Small-scale

0.716

High

252901

EXOC2
Exocyst complex component 2

4

3

High-throughput

0.697

High

252923

EXOC1
Exocyst complex component 1

4

1

High-throughput

0.697

High

252927

EXOC7
Exocyst complex component 7

4

4

High-throughput

0.697

High

252887

EXOC6
Exocyst complex component 6

4

2

High-throughput

0.691

High

252929

EXC6B
Exocyst complex component 6B

4

2

High-throughput

0.691

High

252837

BASI
Basigin

3

2

High-throughput

0.667

High

252883

EXOC8
Exocyst complex component 8

3

1

High-throughput

0.667

High

252881

GCC2
GRIP and coiled-coil domain-containing protein 2

3

4

High-throughput

0.662

High

252896

DTBP1
Dysbindin

3

0

High-throughput

0.638

High

252866

TRIPB
Thyroid receptor-interacting protein 11

3

0

High-throughput

0.634

High

252857

KLC1
Kinesin light chain 1

2

1

High-throughput

0.628

High

252911

KLC2
Kinesin light chain 2

2

1

High-throughput

0.628

High

51381

FSD2
Fibronectin type III and SPRY domain-containing protein 2

2

1

High-throughput

0.606

High

252836

SDC2
Syndecan-2

3

1

High-throughput

0.604

High

252863

PKD2
Polycystin-2

2

0

High-throughput

0.602

High

252882

IFT20
Intraflagellar transport protein 20 homolog

2

0

High-throughput

0.602

High

252902

SCLT1
Sodium channel and clathrin linker 1

2

0

High-throughput

0.602

High

252931

KIF3A
Kinesin-like protein KIF3A

2

0

High-throughput

0.602

High

252826

FPR1
fMet-Leu-Phe receptor

2

5

High-throughput

0.601

High

252804

EGFR
Epidermal growth factor receptor

2

2

Small-scale

0.584

High

252805

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

252806

RASK
GTPase KRas

2

3

High-throughput

0.584

High

252848

RB11A
Ras-related protein Rab-11A

2

1

High-throughput

0.584

High

252807

GLPA
Glycophorin-A

2

0

High-throughput

0.576

High

252924

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.576

High

252813

RGPD2
RANBP2-like and GRIP domain-containing protein 2

2

3

High-throughput

0.574

High

252904

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

2

3

High-throughput

0.574

High

252908

KXDL1
KxDL motif-containing protein 1

2

1

High-throughput

0.574

High

252899

GMCL1
Germ cell-less protein-like 1

2

1

High-throughput

0.553

High

182429

GP182
G-protein coupled receptor 182

2

6

High-throughput

0.549

High

252861

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

5

High-throughput

0.549

High

224190

BUB3
Mitotic checkpoint protein BUB3

1

1

High-throughput

0.541

High

122680

KIF2A
Kinesin-like protein KIF2A

1

1

High-throughput

0.536

High

210373

MTLR
Motilin receptor

1

5

High-throughput

0.536

High

252797

CCD22
Coiled-coil domain-containing protein 22

1

1

High-throughput

0.536

High

252834

V2R
Vasopressin V2 receptor

1

1

High-throughput

0.536

High

252884

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

3

High-throughput

0.536

High

252885

LRC25
Leucine-rich repeat-containing protein 25

1

1

High-throughput

0.536

High

252864

SNW1
SNW domain-containing protein 1

2

1

Small-scale

0.521

High

252801

KRT37
Keratin, type I cuticular Ha7

1

0

High-throughput

0.513

High

252819

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.513

High

252828

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

252856

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.513

High

252862

TMED1
Transmembrane emp24 domain-containing protein 1

1

0

High-throughput

0.513

High

252910

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.513

High

252917

RABE2
Rab GTPase-binding effector protein 2

1

0

High-throughput

0.513

High

252853

VAMP2
Vesicle-associated membrane protein 2

1

1

Small-scale

0.501

High

252829

EDNRB
Endothelin receptor type B

1

3

High-throughput

0.489

High

252841

PTH2R
Parathyroid hormone 2 receptor

1

2

High-throughput

0.489

High

252847

CXCR4
C-X-C chemokine receptor type 4

1

5

High-throughput

0.489

High

252905

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

1

High-throughput

0.489

High

252906

CML1
Chemerin-like receptor 1

1

5

High-throughput

0.489

High

252915

CSTN2
Calsyntenin-2

1

2

High-throughput

0.489

High

252810

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

123950

SNP23
Synaptosomal-associated protein 23

1

1

Small-scale

0.479

High

126391

RHOD
Rho-related GTP-binding protein RhoD

1

8

High-throughput

0.479

High

252796

EXOC3
Exocyst complex component 3

1

2

High-throughput

0.479

High

252811

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.479

High

252812

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

252815

RALA
Ras-related protein Ral-A

1

4

Small-scale

0.479

High

252816

RALB
Ras-related protein Ral-B

1

3

High-throughput

0.479

High

252824

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.479

High

252825

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

252832

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.479

High

252833

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

252843

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

252844

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.479

High

252845

RAC3
Ras-related C3 botulinum toxin substrate 3

1

5

High-throughput

0.479

High

252846

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

252849

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.479

High

252852

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

252854

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.479

High

252858

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

252859

TRI32
E3 ubiquitin-protein ligase TRIM32

1

1

High-throughput

0.479

High

252865

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.479

High

252871

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

252874

RHOU
Rho-related GTP-binding protein RhoU

1

7

High-throughput

0.479

High

252920

RHOF
Rho-related GTP-binding protein RhoF

1

7

High-throughput

0.479

High

252932

MYO5A
Unconventional myosin-Va

1

2

Small-scale

0.479

High

189336

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

225877

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

252803

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

252818

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

252821

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

252827

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

252851

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

252855

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

252877

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

Small-scale

0.458

High

252886

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

252891

DLG3
Disks large homolog 3

1

0

Small-scale

0.458

High

252892

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

252895

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

252912

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

252914

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

252925

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

252928

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.458

High

252808

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

252820

RHOQ
Rho-related GTP-binding protein RhoQ

1

6

High-throughput

0.437

High

252850

H4
Histone H4

1

1

High-throughput

0.437

High

252860

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

2

Small-scale

0.437

High

252873

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

252890

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

252898

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

252916

RHOJ
Rho-related GTP-binding protein RhoJ

1

6

High-throughput

0.437

High

252919

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.437

High

252926

PRP19
Pre-mRNA-processing factor 19

1

1

Small-scale

0.437

High

171370

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.426

High

252897

AURKB
Aurora kinase B

1

0

High-throughput

0.426

High

252918

ZDH11
Palmitoyltransferase ZDHHC11

1

0

High-throughput

0.426

High

252930

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.426

High

161581

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

3

High-throughput

0.407

High

252798

SCN2B
Sodium channel regulatory subunit beta-2

1

1

High-throughput

0.407

High

252823

SDC1
Syndecan-1

1

1

High-throughput

0.407

High

252835

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.407

High

252839

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

2

High-throughput

0.407

High

252842

CXCR3
C-X-C chemokine receptor type 3

1

4

High-throughput

0.407

High

252878

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

6

High-throughput

0.407

High

252880

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

1

High-throughput

0.407

High

252889

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

252831

IL1R2
Interleukin-1 receptor type 2

2

0

High-throughput

0.328

High

252868

KIZ
Centrosomal protein kizuna

2

0

High-throughput

0.328

High

252888

PIBF1
Progesterone-induced-blocking factor 1

2

0

High-throughput

0.328

High

252900

CC136
Coiled-coil domain-containing protein 136

2

0

High-throughput

0.328

High

252907

MACD1
ADP-ribose glycohydrolase MACROD1

2

0

High-throughput

0.328

High

252909

PP12C
Protein phosphatase 1 regulatory subunit 12C

2

0

High-throughput

0.316

High

252822

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

0

High-throughput

0.305

High

252840

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.279

Low

252869

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

252903

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

252921

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

0

High-throughput

0.279

Low

252870

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

0

High-throughput

0.269

Low

252838

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.265

Low

139775

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

252799

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

252800

FLOT1
Flotillin-1

1

0

High-throughput

0.249

Low

252802

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

252809

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.249

Low

252817

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

252867

OCLN
Occludin

1

0

High-throughput

0.249

Low

252872

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

252875

KHDC4
KH homology domain-containing protein 4

1

0

Small-scale

0.249

Low

252876

LAP4B
Lysosomal-associated transmembrane protein 4B

1

0

Small-scale

0.249

Low

252879

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

252893

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

50454

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

252814

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.232

Low

252830

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.232

Low

252913

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.232

Low

252922

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025