Protein: MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)

Gene: MKNK1
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9BUB5

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158174

MK14
Mitogen-activated protein kinase 14

9

20

Small-scale

0.977

High

703695

MK01
Mitogen-activated protein kinase 1

8

20

Small-scale

0.969

High

691837

MK03
Mitogen-activated protein kinase 3

2

20

Small-scale

0.799

High

468751

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.698

High

1405837

DNJC7
DnaJ homolog subfamily C member 7

1

5

High-throughput

0.698

High

230566

KIF1C
Kinesin-like protein KIF1C

1

5

High-throughput

0.691

High

631443

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.691

High

841026

FRK
Tyrosine-protein kinase FRK

1

13

High-throughput

0.691

High

1153379

MK11
Mitogen-activated protein kinase 11

1

20

High-throughput

0.691

High

1160274

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

6

High-throughput

0.691

High

1328476

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

20

High-throughput

0.691

High

1414065

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

17

High-throughput

0.691

High

1414066

PAR6B
Partitioning defective 6 homolog beta

1

5

High-throughput

0.691

High

1414070

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

18

High-throughput

0.691

High

1047089

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

3

5

Small-scale

0.681

High

1414067

HIPK2
Homeodomain-interacting protein kinase 2

1

20

High-throughput

0.621

High

1154920

NEDD8
Ubiquitin-like protein NEDD8

1

2

High-throughput

0.618

High

1040643

CREM
cAMP-responsive element modulator

2

10

High-throughput

0.606

High

221177

SPY2
Protein sprouty homolog 2

1

3

Small-scale

0.561

High

1386986

RCN3
Reticulocalbin-3

1

13

High-throughput

0.555

High

1008318

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.541

High

1368472

CBP
CREB-binding protein

1

10

High-throughput

0.541

High

175184

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.536

High

272745

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

14

High-throughput

0.536

High

326009

UBR5
E3 ubiquitin-protein ligase UBR5

1

16

High-throughput

0.536

High

414530

P53
Cellular tumor antigen p53

1

7

High-throughput

0.536

High

775594

NU214
Nuclear pore complex protein Nup214

1

6

High-throughput

0.536

High

832330

ID1
DNA-binding protein inhibitor ID-1

1

2

High-throughput

0.536

High

925970

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

High-throughput

0.536

High

986679

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.536

High

1142648

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.536

High

1241032

L2GL2
LLGL scribble cell polarity complex component 2

1

1

High-throughput

0.536

High

1308657

AHNK2
Protein AHNAK2

1

2

High-throughput

0.536

High

1338699

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

16

High-throughput

0.536

High

1341365

KI18A
Kinesin-like protein KIF18A

1

6

High-throughput

0.536

High

1369755

RAD50
DNA repair protein RAD50

1

18

High-throughput

0.536

High

1414073

MYH13
Myosin-13

1

11

High-throughput

0.536

High

1414074

AMOL2
Angiomotin-like protein 2

1

19

High-throughput

0.536

High

445594

IF4E
Eukaryotic translation initiation factor 4E

1

4

Small-scale

0.534

High

994355

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

8

Small-scale

0.515

High

1005715

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

5

Small-scale

0.515

High

843932

HD
Huntingtin

1

2

High-throughput

0.515

High

927523

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

1386554

OPTN
Optineurin

1

20

High-throughput

0.515

High

1215563

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.513

High

1414072

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

216124

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

5

High-throughput

0.508

High

906763

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

4

High-throughput

0.508

High

927120

ATX3
Ataxin-3

1

1

High-throughput

0.508

High

1414069

PHAX
Phosphorylated adapter RNA export protein

1

1

High-throughput

0.508

High

423037

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.501

High

630346

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.489

High

1322505

PUSL1
tRNA pseudouridine synthase-like 1

1

1

High-throughput

0.489

High

169732

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.481

High

173295

XPO1
Exportin-1

1

7

High-throughput

0.479

High

607060

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

851656

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

1414068

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

350306

DDAH2
Putative hydrolase DDAH2

1

2

High-throughput

0.464

High

187553

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.460

High

1339682

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.460

High

1208804

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.458

High

1238367

RETST
All-trans-retinol 13,14-reductase

1

1

High-throughput

0.437

High

191483

CCL16
C-C motif chemokine 16

1

0

High-throughput

0.279

Low

1083143

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.279

Low

1256690

CC149
Coiled-coil domain-containing protein 149

1

0

High-throughput

0.279

Low

1352929

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.279

Low

1414071

BPIA1
BPI fold-containing family A member 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025