Protein: PFD3
Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1)

Gene: PFD3, VBP1
Organism: Homo sapiens
Interactions: 177
UniProt ID: P61758

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

963386

PFD2
Prefoldin subunit 2

14

4

Small-scale

0.980

High

963376

PFD4
Prefoldin subunit 4

8

2

High-throughput

0.971

High

963359

PFD5
Prefoldin subunit 5

6

4

Small-scale

0.946

High

182102

PFD6
Prefoldin subunit 6

5

2

High-throughput

0.927

High

261784

PFD1
Prefoldin subunit 1

4

1

High-throughput

0.892

High

963277

TCPB
T-complex protein 1 subunit beta

2

3

High-throughput

0.789

High

963378

PDRG1
p53 and DNA damage-regulated protein 1

2

0

High-throughput

0.770

High

963358

UBL7
Ubiquitin-like protein 7

5

0

High-throughput

0.694

High

963284

MK07
Mitogen-activated protein kinase 7

4

1

High-throughput

0.691

High

963290

HDAC1
Histone deacetylase 1

4

1

High-throughput

0.691

High

822569

VHL
von Hippel-Lindau disease tumor suppressor

5

0

Small-scale

0.681

High

963317

TBA1A
Tubulin alpha-1A chain

4

5

High-throughput

0.673

High

142321

PEX7
Peroxisomal targeting signal 2 receptor

3

5

High-throughput

0.667

High

963268

DCAF7
DDB1- and CUL4-associated factor 7

3

5

High-throughput

0.667

High

963273

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

3

6

High-throughput

0.667

High

963353

DCAF5
DDB1- and CUL4-associated factor 5

3

8

High-throughput

0.667

High

963368

SKI8
Superkiller complex protein 8

3

6

High-throughput

0.667

High

581478

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

2

1

High-throughput

0.628

High

821286

TCPZ
T-complex protein 1 subunit zeta

1

3

High-throughput

0.618

High

875895

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.618

High

881858

TCPG
T-complex protein 1 subunit gamma

1

3

High-throughput

0.618

High

898978

TCPQ
T-complex protein 1 subunit theta

1

4

High-throughput

0.618

High

899323

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.618

High

963362

TCPH
T-complex protein 1 subunit eta

1

3

High-throughput

0.618

High

191258

MSH4
MutS protein homolog 4

2

1

Small-scale

0.606

High

681779

RBTN2
Rhombotin-2

2

2

High-throughput

0.606

High

682017

RBTN1
Rhombotin-1

2

2

High-throughput

0.606

High

963328

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

1

High-throughput

0.606

High

963333

LMO3
LIM domain only protein 3

2

2

High-throughput

0.606

High

963370

ZN576
Zinc finger protein 576

2

1

High-throughput

0.606

High

963346

KPBB
Phosphorylase b kinase regulatory subunit beta

2

0

High-throughput

0.602

High

963375

COPRS
Coordinator of PRMT5 and differentiation stimulator

2

0

High-throughput

0.602

High

963382

STK26
Serine/threonine-protein kinase 26

2

0

High-throughput

0.602

High

963287

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

4

High-throughput

0.584

High

963363

DUS9
Dual specificity protein phosphatase 9

2

3

High-throughput

0.584

High

225559

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

0

High-throughput

0.580

High

426946

FGF1
Fibroblast growth factor 1

2

0

High-throughput

0.580

High

963292

VEZF1
Vascular endothelial zinc finger 1

2

0

High-throughput

0.580

High

963322

ZN410
Zinc finger protein 410

2

0

High-throughput

0.580

High

963324

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.580

High

963349

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

963367

GLIS2
Zinc finger protein GLIS2

2

0

High-throughput

0.580

High

963374

MYOZ1
Myozenin-1

2

0

High-throughput

0.580

High

963379

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

963387

IKZF3
Zinc finger protein Aiolos

2

0

High-throughput

0.580

High

963394

T22D4
TSC22 domain family protein 4

2

0

High-throughput

0.580

High

934377

TERA
Transitional endoplasmic reticulum ATPase

2

1

Small-scale

0.571

High

963391

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.561

High

963330

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.549

High

963297

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.537

High

209229

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

7

High-throughput

0.536

High

529497

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

698254

MAP4
Microtubule-associated protein 4

1

1

High-throughput

0.536

High

963274

TBA1B
Tubulin alpha-1B chain

1

5

High-throughput

0.536

High

963276

TBB4B
Tubulin beta-4B chain

1

4

High-throughput

0.536

High

963296

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

1

High-throughput

0.536

High

963298

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

1

High-throughput

0.536

High

963302

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.536

High

963325

FBXW8
F-box/WD repeat-containing protein 8

1

4

Small-scale

0.536

High

963332

WDR48
WD repeat-containing protein 48

1

4

High-throughput

0.536

High

963334

UHMK1
Serine/threonine-protein kinase Kist

1

2

High-throughput

0.536

High

963311

TBA3E
Tubulin alpha-3E chain

1

4

High-throughput

0.515

High

963310

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

64859

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.513

High

67644

RHG32
Rho GTPase-activating protein 32

1

0

High-throughput

0.513

High

276679

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

0

High-throughput

0.513

High

724462

GDIA
Rab GDP dissociation inhibitor alpha

1

0

High-throughput

0.513

High

905535

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

948518

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

963271

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

0

High-throughput

0.513

High

963294

EPN4
Clathrin interactor 1

1

0

High-throughput

0.513

High

963299

PCGF3
Polycomb group RING finger protein 3

1

0

High-throughput

0.513

High

963301

KR133
Keratin-associated protein 13-3

1

0

High-throughput

0.513

High

963336

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.513

High

963360

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

0

High-throughput

0.513

High

963377

NRBP2
Nuclear receptor-binding protein 2

1

0

High-throughput

0.513

High

963383

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

0

High-throughput

0.513

High

963385

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

0

High-throughput

0.513

High

224547

ST1B1
Sulfotransferase 1B1

1

0

High-throughput

0.493

High

963280

GABP1
GA-binding protein subunit beta-1

1

0

High-throughput

0.493

High

963293

BECN1
Beclin-1

1

0

High-throughput

0.493

High

963354

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

0

High-throughput

0.493

High

963356

ZN488
Zinc finger protein 488

1

0

High-throughput

0.493

High

963381

ZN581
Zinc finger protein 581

1

0

High-throughput

0.493

High

963392

ZN232
Zinc finger protein 232

1

0

High-throughput

0.493

High

558004

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

963343

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

0

High-throughput

0.486

High

893798

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

507766

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

156613

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

4

High-throughput

0.479

High

256816

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

341544

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

457345

TBB5
Tubulin beta chain

1

4

High-throughput

0.479

High

861973

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

958075

ARP3
Actin-related protein 3

1

1

High-throughput

0.479

High

963269

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

963275

TBA4A
Tubulin alpha-4A chain

1

4

High-throughput

0.479

High

963278

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

963285

DUS8
Dual specificity protein phosphatase 8

1

3

High-throughput

0.479

High

963286

ERCC8
DNA excision repair protein ERCC-8

1

6

High-throughput

0.479

High

963295

SKI2
Superkiller complex protein 2

1

1

High-throughput

0.479

High

963304

DCAF6
DDB1- and CUL4-associated factor 6

1

10

High-throughput

0.479

High

963306

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

963312

SKI3
Superkiller complex protein 3

1

1

High-throughput

0.479

High

963326

WDTC1
WD and tetratricopeptide repeats protein 1

1

9

High-throughput

0.479

High

963329

POC1A
POC1 centriolar protein homolog A

1

6

High-throughput

0.479

High

963331

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

963335

POC1B
POC1 centriolar protein homolog B

1

6

High-throughput

0.479

High

963344

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

963345

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.479

High

963350

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

963351

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

High-throughput

0.479

High

963364

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

4

High-throughput

0.479

High

963365

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

5

High-throughput

0.479

High

963366

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.479

High

963380

WSB2
WD repeat and SOCS box-containing protein 2

1

5

High-throughput

0.479

High

963384

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

963388

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

963390

PRP19
Pre-mRNA-processing factor 19

1

6

High-throughput

0.479

High

963393

FBW1A
F-box/WD repeat-containing protein 1A

1

2

High-throughput

0.479

High

963373

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

0

Small-scale

0.460

High

259716

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

293479

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

332752

EPM2A
Laforin

1

0

High-throughput

0.458

High

371639

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

606538

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

761619

HSP74
Heat shock 70 kDa protein 4

1

0

Small-scale

0.458

High

830472

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

958407

ACTZ
Alpha-centractin

1

0

High-throughput

0.458

High

963270

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

963281

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

963282

FOXI1
Forkhead box protein I1

1

0

High-throughput

0.458

High

963283

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

963288

MTM1
Myotubularin

1

0

High-throughput

0.458

High

963291

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

963309

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

963315

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

963320

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

963321

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

963323

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

963339

SMAP2
Stromal membrane-associated protein 2

1

0

High-throughput

0.458

High

963342

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

963347

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.458

High

963355

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

963361

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

0

High-throughput

0.458

High

963371

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

963372

RC3H2
Roquin-2

1

0

High-throughput

0.458

High

963272

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

High-throughput

0.445

High

963289

TBB3
Tubulin beta-3 chain

1

4

High-throughput

0.445

High

963300

DC4L1
DDB1- and CUL4-associated factor 4-like protein 1

1

1

High-throughput

0.445

High

963307

DCAF8
DDB1- and CUL4-associated factor 8

1

9

High-throughput

0.445

High

963341

DDB2
DNA damage-binding protein 2

1

7

High-throughput

0.445

High

168836

PLD2
Phospholipase D2

1

1

High-throughput

0.437

High

963313

TTC33
Tetratricopeptide repeat protein 33

1

1

High-throughput

0.437

High

963314

WDR82
WD repeat-containing protein 82

1

7

High-throughput

0.437

High

963337

DCA11
DDB1- and CUL4-associated factor 11

1

6

High-throughput

0.437

High

963340

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

963396

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

3

High-throughput

0.437

High

960363

SMS
Somatostatin

1

0

Small-scale

0.426

High

963357

MYCT
Proton myo-inositol cotransporter

1

0

High-throughput

0.426

High

963308

DC122
DDB1- and CUL4-associated factor 12-like protein 2

1

1

High-throughput

0.407

High

963318

SPT6H
Transcription elongation factor SPT6

2

0

High-throughput

0.328

High

963352

SGF29
SAGA-associated factor 29

2

0

High-throughput

0.328

High

350444

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

0

High-throughput

0.316

High

907126

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

963305

EFHC1
EF-hand domain-containing protein 1

2

0

High-throughput

0.316

High

963369

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

963303

KLH26
Kelch-like protein 26

1

0

High-throughput

0.279

Low

963316

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.279

Low

963319

PBIR2
PABIR family member 2

1

0

High-throughput

0.279

Low

963327

DB123
Beta-defensin 123

1

0

High-throughput

0.279

Low

963338

THAP3
THAP domain-containing protein 3

1

0

High-throughput

0.268

Low

767866

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

963279

RON
Macrophage-stimulating protein receptor

1

0

High-throughput

0.249

Low

963389

ALK
ALK tyrosine kinase receptor

1

0

High-throughput

0.249

Low

963395

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low

963348

ESPB1
Epididymal sperm-binding protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025