Protein: R3GEF
Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1)

Gene: R3GEF, RAB3IL1
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q8TBN0

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0015031 - protein transport
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1349051

RAB3I
Rab-3A-interacting protein

7

2

High-throughput

0.975

High

1349044

R3GEF
Guanine nucleotide exchange factor for Rab-3A

3

2

High-throughput

0.860

High

955975

RAB8A
Ras-related protein Rab-8A

3

3

Small-scale

0.849

High

976437

RB11A
Ras-related protein Rab-11A

3

1

High-throughput

0.845

High

630430

RAB3A
Ras-related protein Rab-3A

2

7

High-throughput

0.783

High

1197029

AMOT
Angiomotin

3

2

High-throughput

0.667

High

271631

LIPA3
Liprin-alpha-3

3

0

High-throughput

0.638

High

1349048

OPTN
Optineurin

3

0

High-throughput

0.638

High

1349049

ATG4C
Cysteine protease ATG4C

3

0

High-throughput

0.638

High

1331941

TM102
Transmembrane protein 102

4

3

High-throughput

0.633

High

1256871

NUD18
8-oxo-dGDP phosphatase NUDT18

2

0

High-throughput

0.613

High

1277327

NT2NA
Notch homolog 2 N-terminal-like protein A

3

1

High-throughput

0.609

High

300438

KRT34
Keratin, type I cuticular Ha4

2

2

High-throughput

0.606

High

1287587

TTC7B
Tetratricopeptide repeat protein 7B

2

1

High-throughput

0.606

High

1203199

ODFP2
Outer dense fiber protein 2

2

0

High-throughput

0.585

High

1349045

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

2

0

High-throughput

0.585

High

269311

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1159611

STX1A
Syntaxin-1A

2

0

High-throughput

0.580

High

1349055

CN119
Uncharacterized protein C14orf119

2

0

High-throughput

0.580

High

1349060

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.580

High

845239

GDF5
Growth/differentiation factor 5

2

1

High-throughput

0.574

High

1230159

K1C40
Keratin, type I cytoskeletal 40

1

2

High-throughput

0.573

High

1216141

FHL5
Four and a half LIM domains protein 5

2

2

High-throughput

0.553

High

681457

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.549

High

1315103

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.536

High

451630

GPX1
Glutathione peroxidase 1

1

0

High-throughput

0.513

High

984209

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.513

High

1030323

AMPD2
AMP deaminase 2

1

0

High-throughput

0.513

High

1040742

ENL
Protein ENL

1

0

High-throughput

0.513

High

1098813

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

3

Small-scale

0.501

High

1186778

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

1349046

IP6K1
Inositol hexakisphosphate kinase 1

1

0

Small-scale

0.480

High

221749

TPPC3
Trafficking protein particle complex subunit 3

1

1

High-throughput

0.479

High

874053

TPC10
Trafficking protein particle complex subunit 10

1

1

High-throughput

0.479

High

1314084

AMOL1
Angiomotin-like protein 1

1

1

High-throughput

0.479

High

1349050

TPPC9
Trafficking protein particle complex subunit 9

1

1

High-throughput

0.479

High

1349053

PDLI7
PDZ and LIM domain protein 7

1

1

High-throughput

0.479

High

1349057

TPC2L
Trafficking protein particle complex subunit 2-like protein

1

2

High-throughput

0.479

High

1349059

TPPC4
Trafficking protein particle complex subunit 4

1

3

High-throughput

0.479

High

1349061

TPPC1
Trafficking protein particle complex subunit 1

1

3

High-throughput

0.479

High

517069

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

867807

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.458

High

1314631

M21D2
Nucleotidyltransferase MB21D2

1

3

High-throughput

0.437

High

1349056

MIC19
MICOS complex subunit MIC19

1

1

High-throughput

0.417

High

1205898

MTUS2
Microtubule-associated tumor suppressor candidate 2

4

0

High-throughput

0.364

High

1311584

SUGP2
SURP and G-patch domain-containing protein 2

3

0

High-throughput

0.347

High

1349047

C102A
Coiled-coil domain-containing protein 102A

3

0

High-throughput

0.347

High

1349054

CYRIB
CYFIP-related Rac1 interactor B

2

0

High-throughput

0.328

High

70376

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1179266

CB068
UPF0561 protein C2orf68

2

0

High-throughput

0.316

High

1349052

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

2

0

High-throughput

0.316

High

1179993

CCD57
Coiled-coil domain-containing protein 57

1

0

High-throughput

0.299

High

1238052

TIGD7
Tigger transposable element-derived protein 7

1

0

High-throughput

0.299

High

1349058

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.299

High

1244734

KLD10
Kelch domain-containing protein 10

1

0

High-throughput

0.279

Low

1322114

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

585

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.251

Low

1276516

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025