Protein: PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)

Gene: PI42C, PIP4K2C
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q8TBX8

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005776 - autophagosome
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

871983

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

6

14

High-throughput

0.945

High

1006152

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

2

14

High-throughput

0.776

High

1349198

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

13

Small-scale

0.713

High

1349212

EAF1
ELL-associated factor 1

4

4

High-throughput

0.691

High

279429

TULP3
Tubby-related protein 3

3

2

High-throughput

0.667

High

329776

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

3

2

High-throughput

0.667

High

625514

CSK22
Casein kinase II subunit alpha'

3

11

High-throughput

0.667

High

1349218

LZTS2
Leucine zipper putative tumor suppressor 2

3

4

High-throughput

0.667

High

1335358

CAMKV
CaM kinase-like vesicle-associated protein

3

4

High-throughput

0.662

High

230651

PRIC3
Prickle planar cell polarity protein 3

2

2

High-throughput

0.628

High

355091

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

2

5

High-throughput

0.628

High

622640

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

2

High-throughput

0.628

High

1279142

RHG22
Rho GTPase-activating protein 22

2

4

High-throughput

0.628

High

1314824

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

2

1

High-throughput

0.628

High

1349211

SAHH3
Adenosylhomocysteinase 3

2

6

High-throughput

0.628

High

1349227

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

2

3

High-throughput

0.628

High

260201

BRD4
Bromodomain-containing protein 4

2

11

High-throughput

0.611

High

1349219

RIOK2
Serine/threonine-protein kinase RIO2

2

1

High-throughput

0.611

High

1226786

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

3

2

High-throughput

0.609

High

1349207

ZN428
Zinc finger protein 428

3

2

High-throughput

0.604

High

1349225

TNR19
Tumor necrosis factor receptor superfamily member 19

2

0

High-throughput

0.602

High

414265

P53
Cellular tumor antigen p53

2

1

High-throughput

0.601

High

1145289

RNPS1
RNA-binding protein with serine-rich domain 1

2

4

High-throughput

0.601

High

1154403

STK11
Serine/threonine-protein kinase STK11

2

4

High-throughput

0.601

High

1141231

BRD3
Bromodomain-containing protein 3

3

11

High-throughput

0.599

High

242357

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

1349199

POC1B
POC1 centriolar protein homolog B

2

3

High-throughput

0.574

High

1349222

GPBL1
Vasculin-like protein 1

2

2

High-throughput

0.574

High

1349231

SUN2
SUN domain-containing protein 2

2

2

High-throughput

0.574

High

1278772

HDGR2
Hepatoma-derived growth factor-related protein 2

2

2

High-throughput

0.549

High

230079

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.536

High

269794

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

3

High-throughput

0.536

High

604706

UBF1
Nucleolar transcription factor 1

1

2

High-throughput

0.536

High

718433

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.536

High

959621

MAX
Protein max

1

5

High-throughput

0.536

High

1122292

SCRIB
Protein scribble homolog

1

2

High-throughput

0.536

High

1134494

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

High-throughput

0.536

High

1144906

RASA2
Ras GTPase-activating protein 2

1

2

High-throughput

0.536

High

1243709

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

2

High-throughput

0.536

High

1273755

STRAA
STE20-related kinase adapter protein alpha

1

7

High-throughput

0.536

High

1311633

KIBRA
Protein KIBRA

1

6

High-throughput

0.536

High

1325058

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

3

High-throughput

0.536

High

1349202

MADD
MAP kinase-activating death domain protein

1

5

High-throughput

0.536

High

1349203

RTF1
RNA polymerase-associated protein RTF1 homolog

1

1

High-throughput

0.536

High

1349206

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

2

High-throughput

0.536

High

1349220

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.536

High

1349223

E41L5
Band 4.1-like protein 5

1

6

High-throughput

0.536

High

1349224

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.536

High

1349232

AFF4
AF4/FMR2 family member 4

1

4

High-throughput

0.536

High

1349233

TAOK2
Serine/threonine-protein kinase TAO2

1

5

High-throughput

0.536

High

1349235

E41L3
Band 4.1-like protein 3

1

4

High-throughput

0.536

High

1349236

CAB39
Calcium-binding protein 39

1

1

High-throughput

0.536

High

532798

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

602818

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

958313

ARP2
Actin-related protein 2

1

0

High-throughput

0.513

High

1311250

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

0

High-throughput

0.513

High

1331821

SYT2
Synaptotagmin-2

1

0

High-throughput

0.513

High

1349210

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

1349217

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

1349228

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.513

High

422681

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

126154

AP3B1
AP-3 complex subunit beta-1

1

5

High-throughput

0.489

High

282528

PAGE1
P antigen family member 1

1

1

High-throughput

0.489

High

1348919

ZCH10
Zinc finger CCHC domain-containing protein 10

1

2

High-throughput

0.489

High

1349208

CSTOS
Protein CUSTOS

1

1

High-throughput

0.489

High

1349209

ATG4C
Cysteine protease ATG4C

1

2

High-throughput

0.489

High

1349214

CC85A
Coiled-coil domain-containing protein 85A

1

3

High-throughput

0.489

High

1349234

DIP2C
Disco-interacting protein 2 homolog C

1

1

High-throughput

0.489

High

1349238

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

185875

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

372646

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

443453

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.479

High

578517

BRAF
Serine/threonine-protein kinase B-raf

1

3

High-throughput

0.479

High

674257

BRD2
Bromodomain-containing protein 2

1

10

High-throughput

0.479

High

720514

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.479

High

767277

MERL
Merlin

1

6

High-throughput

0.479

High

768704

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

876943

KC1A
Casein kinase I isoform alpha

1

9

High-throughput

0.479

High

879291

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

970814

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

978181

RHOB
Rho-related GTP-binding protein RhoB

1

9

High-throughput

0.479

High

986589

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

992508

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.479

High

997883

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.479

High

1115312

CUL4B
Cullin-4B

1

2

Small-scale

0.479

High

1116260

PTC1
Protein patched homolog 1

1

3

Small-scale

0.479

High

1124381

ELOA1
Elongin-A

1

1

High-throughput

0.479

High

1137876

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1252344

MEX3B
RNA-binding protein MEX3B

1

2

High-throughput

0.479

High

1330290

KC1AL
Casein kinase I isoform alpha-like

1

9

High-throughput

0.479

High

1332823

PR38A
Pre-mRNA-splicing factor 38A

1

1

High-throughput

0.479

High

1337818

CSK23
Casein kinase II subunit alpha 3

1

8

High-throughput

0.479

High

1349204

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

1349205

KAT6A
Histone acetyltransferase KAT6A

1

1

Small-scale

0.479

High

1349213

SNX27
Sorting nexin-27

1

4

High-throughput

0.479

High

1349221

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

1349230

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

159763

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

1138421

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1139649

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.458

High

1338820

FLCN
Folliculin

1

0

Small-scale

0.458

High

1349229

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

High-throughput

0.458

High

848804

MAGAA
Melanoma-associated antigen 10

1

4

High-throughput

0.445

High

1349215

S38A2
Sodium-coupled neutral amino acid symporter 2

1

2

High-throughput

0.445

High

1349216

CCNL2
Cyclin-L2

1

2

High-throughput

0.445

High

1349226

EXOC1
Exocyst complex component 1

1

2

High-throughput

0.445

High

1168537

KNOP1
Lysine-rich nucleolar protein 1

1

1

High-throughput

0.437

High

1212076

SPOUT
28S rRNA

1

1

High-throughput

0.437

High

1241911

FBX42
F-box only protein 42

1

4

High-throughput

0.437

High

1254752

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1349201

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

1

Small-scale

0.437

High

1349237

MAFB
Transcription factor MafB

1

3

High-throughput

0.437

High

1315502

DAAF8
Dynein axonemal assembly factor 8

2

0

High-throughput

0.328

High

1339818

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

Small-scale

0.261

Low

1349200

FBX25
F-box only protein 25

1

0

Small-scale

0.261

Low

516110

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025