Protein: PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)

Gene: PI42B, PIP4K2B
Organism: Homo sapiens
Interactions: 87
UniProt ID: P78356

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005525 - GTP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005776 - autophagosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

871921

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

4

14

High-throughput

0.900

High

1006152

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

2

14

High-throughput

0.776

High

329726

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

3

2

High-throughput

0.667

High

1006142

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

3

2

High-throughput

0.667

High

1006163

EAF1
ELL-associated factor 1

3

4

High-throughput

0.667

High

1006177

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

3

High-throughput

0.662

High

997629

CSK21
Casein kinase II subunit alpha

3

8

High-throughput

0.653

High

1006138

RNPS1
RNA-binding protein with serine-rich domain 1

3

4

High-throughput

0.650

High

230627

PRIC3
Prickle planar cell polarity protein 3

2

2

High-throughput

0.628

High

1006147

RHG22
Rho GTPase-activating protein 22

2

4

High-throughput

0.628

High

1006162

SAHH3
Adenosylhomocysteinase 3

2

6

High-throughput

0.628

High

1006168

LZTS2
Leucine zipper putative tumor suppressor 2

2

4

High-throughput

0.628

High

1006172

GPBL1
Vasculin-like protein 1

2

2

High-throughput

0.628

High

279335

TULP3
Tubby-related protein 3

2

2

High-throughput

0.611

High

625308

CSK22
Casein kinase II subunit alpha'

2

11

High-throughput

0.611

High

215078

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

1

High-throughput

0.606

High

913757

ZN131
Zinc finger protein 131

2

2

High-throughput

0.606

High

1006159

ZN428
Zinc finger protein 428

3

2

High-throughput

0.604

High

230002

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

6

High-throughput

0.601

High

529609

TAU
Microtubule-associated protein tau

2

5

High-throughput

0.601

High

1006140

STK11
Serine/threonine-protein kinase STK11

2

4

High-throughput

0.601

High

1006146

HDGR2
Hepatoma-derived growth factor-related protein 2

2

2

High-throughput

0.601

High

1006170

SPY4
Protein sprouty homolog 4

2

0

High-throughput

0.595

High

259781

BRD4
Bromodomain-containing protein 4

2

11

High-throughput

0.584

High

633658

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

827377

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

1006141

KYNU
Kynureninase

2

0

High-throughput

0.580

High

1006161

CDA7L
Cell division cycle-associated 7-like protein

2

0

High-throughput

0.580

High

1006171

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1006174

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

0

High-throughput

0.580

High

1006179

HSPB7
Heat shock protein beta-7

2

0

High-throughput

0.580

High

1006132

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

13

Small-scale

0.575

High

1006180

SUN2
SUN domain-containing protein 2

2

2

High-throughput

0.574

High

227499

SPOP
Speckle-type POZ protein

1

1

Small-scale

0.573

High

622579

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.573

High

1006144

HMBX1
Homeobox-containing protein 1

1

1

High-throughput

0.573

High

1006175

UBQL4
Ubiquilin-4

1

2

High-throughput

0.541

High

718383

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.536

High

959557

MAX
Protein max

1

5

High-throughput

0.536

High

1006135

SCRIB
Protein scribble homolog

1

2

High-throughput

0.536

High

1006148

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

3

High-throughput

0.536

High

1006154

MADD
MAP kinase-activating death domain protein

1

5

High-throughput

0.536

High

1006173

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.536

High

1006181

TAOK2
Serine/threonine-protein kinase TAO2

1

5

High-throughput

0.536

High

1006184

E41L3
Band 4.1-like protein 3

1

4

High-throughput

0.536

High

167689

LIN7A
Protein lin-7 homolog A

1

0

High-throughput

0.513

High

889393

CLK1
Dual specificity protein kinase CLK1

1

4

High-throughput

0.501

High

155570

NEMP1
Nuclear envelope integral membrane protein 1

1

1

High-throughput

0.489

High

282518

PAGE1
P antigen family member 1

1

1

High-throughput

0.489

High

1006151

ZCH10
Zinc finger CCHC domain-containing protein 10

1

2

High-throughput

0.489

High

1006160

ATG4C
Cysteine protease ATG4C

1

2

High-throughput

0.489

High

1006165

CC85A
Coiled-coil domain-containing protein 85A

1

3

High-throughput

0.489

High

1006158

TRI63
E3 ubiquitin-protein ligase TRIM63

1

6

High-throughput

0.481

High

1006169

TRI55
Tripartite motif-containing protein 55

1

6

High-throughput

0.481

High

241371

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

443298

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.479

High

623272

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

674134

BRD2
Bromodomain-containing protein 2

1

10

High-throughput

0.479

High

876820

KC1A
Casein kinase I isoform alpha

1

9

High-throughput

0.479

High

878950

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

890448

RBP2
E3 SUMO-protein ligase RanBP2

1

2

High-throughput

0.479

High

970314

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

1006133

CUL4B
Cullin-4B

1

2

Small-scale

0.479

High

1006134

PTC1
Protein patched homolog 1

1

3

Small-scale

0.479

High

1006136

BRD3
Bromodomain-containing protein 3

1

11

High-throughput

0.479

High

1006137

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

1006143

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.479

High

1006149

KC1AL
Casein kinase I isoform alpha-like

1

9

High-throughput

0.479

High

1006150

CSK23
Casein kinase II subunit alpha 3

1

8

High-throughput

0.479

High

1006155

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

1006156

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

7

High-throughput

0.479

High

1006178

CDK12
Cyclin-dependent kinase 12

1

6

High-throughput

0.479

High

1006185

MAFB
Transcription factor MafB

1

3

High-throughput

0.479

High

1006164

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

848770

MAGAA
Melanoma-associated antigen 10

1

4

High-throughput

0.445

High

934451

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

1006157

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

2

High-throughput

0.445

High

1006166

S38A2
Sodium-coupled neutral amino acid symporter 2

1

2

High-throughput

0.445

High

1006167

CCNL2
Cyclin-L2

1

2

High-throughput

0.445

High

1006176

EXOC1
Exocyst complex component 1

1

2

High-throughput

0.445

High

1006182

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.445

High

1006186

TRPV2
Transient receptor potential cation channel subfamily V member 2

1

0

Small-scale

0.438

High

1006145

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1006153

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

1

Small-scale

0.437

High

1006139

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.426

High

1006183

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High


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Last updated: 11Aug2025