Protein: NQO1
NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1)

Gene: NQO1
Organism: Homo sapiens
Interactions: 56
UniProt ID: P15559

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0003723 - RNA binding
GO:0003955 - NAD(P)H dehydrogenase (quinone) activity
GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584844

NQO1
NAD(P)H dehydrogenase [quinone] 1

4

2

Small-scale

0.891

High

413126

P53
Cellular tumor antigen p53

5

1

Small-scale

0.716

High

584879

CHIP
E3 ubiquitin-protein ligase CHIP

2

0

Small-scale

0.603

High

584868

HIF1A
Hypoxia-inducible factor 1-alpha

2

0

Small-scale

0.598

High

584867

NF2L2
Nuclear factor erythroid 2-related factor 2

2

1

Small-scale

0.584

High

462150

GALT
Galactose-1-phosphate uridylyltransferase

2

0

High-throughput

0.580

High

584872

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.571

High

240660

PRKN
E3 ubiquitin-protein ligase parkin

1

1

Small-scale

0.561

High

584849

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.561

High

400233

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.559

High

584860

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.547

High

584862

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

584878

ING1
Inhibitor of growth protein 1

1

0

Small-scale

0.537

High

186501

TRI18
E3 ubiquitin-protein ligase Midline-1

1

3

High-throughput

0.536

High

135880

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

0

High-throughput

0.513

High

187279

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

529004

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

584861

TIE2
Angiopoietin-1 receptor

1

0

High-throughput

0.513

High

584877

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.513

High

584855

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

0

Small-scale

0.480

High

584858

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

370539

FOS
Protein c-Fos

1

1

Small-scale

0.479

High

584846

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

584859

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

584863

TRI26
Tripartite motif-containing protein 26

1

1

Small-scale

0.479

High

584871

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

259383

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

347509

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

486916

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

584848

TYY1
Transcriptional repressor protein YY1

1

0

Small-scale

0.458

High

584850

HSP74
Heat shock 70 kDa protein 4

1

0

Small-scale

0.458

High

584852

ADA1A
Alpha-1A adrenergic receptor

1

0

High-throughput

0.458

High

584853

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

584854

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

584856

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

584864

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

584866

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

584870

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.458

High

584873

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

Small-scale

0.458

High

584874

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

584875

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

584876

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

186693

P73
Tumor protein p73

1

1

Small-scale

0.445

High

584851

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

584845

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

584865

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.426

High

275241

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.279

Low

352924

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

377947

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

388989

FINC
Fibronectin

1

0

High-throughput

0.249

Low

565124

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

584847

TCO2
Transcobalamin-2

1

0

High-throughput

0.249

Low

584857

ATS20
A disintegrin and metalloproteinase with thrombospondin motifs 20

1

0

High-throughput

0.249

Low

584869

CTSRT
Cation channel sperm-associated targeting subunit tau

1

0

High-throughput

0.249

Low

584880

ANR26
Ankyrin repeat domain-containing protein 26

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025