Protein: NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase)

Gene: NADC, QPRT
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q15274

Gene Ontology (top 5):
GO:0004514 - nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009435 - NAD+ biosynthetic process
GO:0019674 - NAD+ metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1144758

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

2

High-throughput

0.845

High

1144774

PATL1
Protein PAT1 homolog 1

4

1

High-throughput

0.691

High

180823

TIF1A
Transcription intermediary factor 1-alpha

3

1

High-throughput

0.667

High

216090

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

3

1

High-throughput

0.667

High

1005677

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

3

1

High-throughput

0.667

High

1144763

CRY1
Cryptochrome-1

3

1

High-throughput

0.667

High

1144764

CRY2
Cryptochrome-2

3

1

High-throughput

0.667

High

1144811

PRC2C
Protein PRRC2C

3

2

High-throughput

0.667

High

135935

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

4

0

High-throughput

0.661

High

225416

CIKS
E3 ubiquitin ligase TRAF3IP2

4

0

High-throughput

0.661

High

1144782

ARI1B
AT-rich interactive domain-containing protein 1B

4

0

High-throughput

0.661

High

950484

KR108
Keratin-associated protein 10-8

3

4

High-throughput

0.654

High

193777

PER1
Period circadian protein homolog 1

3

0

High-throughput

0.638

High

1144795

ARP6
Actin-related protein 6

3

0

High-throughput

0.638

High

1144798

RAVR2
Ribonucleoprotein PTB-binding 2

3

0

High-throughput

0.638

High

345182

ZMYM6
Zinc finger MYM-type protein 6

4

1

High-throughput

0.630

High

1144808

TRI33
E3 ubiquitin-protein ligase TRIM33

4

1

High-throughput

0.630

High

1144787

SEH1
Nucleoporin SEH1

3

0

High-throughput

0.622

High

1144773

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.613

High

326334

SCAF4
SR-related and CTD-associated factor 4

3

1

High-throughput

0.609

High

1032756

SATB1
DNA-binding protein SATB1

3

1

High-throughput

0.609

High

1144760

SF3A1
Splicing factor 3A subunit 1

3

1

High-throughput

0.609

High

1144771

BCOR
BCL-6 corepressor

3

2

High-throughput

0.609

High

1144809

SATB2
DNA-binding protein SATB2

3

1

High-throughput

0.609

High

1059638

KRA11
Keratin-associated protein 1-1

2

4

High-throughput

0.606

High

1047976

TLE3
Transducin-like enhancer protein 3

2

3

High-throughput

0.558

High

1144786

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

2

1

High-throughput

0.558

High

1144813

NCOR2
Nuclear receptor corepressor 2

2

2

High-throughput

0.549

High

1144791

KR412
Keratin-associated protein 4-12

1

4

High-throughput

0.541

High

274151

ANR17
Ankyrin repeat domain-containing protein 17

1

1

High-throughput

0.536

High

1144776

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

1

High-throughput

0.536

High

1144778

TENS4
Tensin-4

1

1

High-throughput

0.536

High

1144807

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.518

High

243943

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.513

High

555489

SKIL
Ski-like protein

1

0

High-throughput

0.513

High

1013390

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.513

High

1144781

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

0

High-throughput

0.513

High

1144792

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.513

High

1144799

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

0

High-throughput

0.513

High

1144793

NPL
N-acetylneuraminate lyase

1

0

High-throughput

0.493

High

1144767

ZMYM4
Zinc finger MYM-type protein 4

1

1

High-throughput

0.489

High

1144788

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

1

High-throughput

0.489

High

1144805

RCOR1
REST corepressor 1

1

2

High-throughput

0.489

High

949882

KR103
Keratin-associated protein 10-3

1

4

High-throughput

0.481

High

1144768

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.481

High

278350

NCOR1
Nuclear receptor corepressor 1

1

3

High-throughput

0.479

High

1047823

TLE1
Transducin-like enhancer protein 1

1

3

High-throughput

0.479

High

1144806

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

188283

HDAC3
Histone deacetylase 3

1

0

High-throughput

0.458

High

396156

ESR1
Estrogen receptor

1

0

High-throughput

0.458

High

951684

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

957392

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

1144766

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

1144797

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

0

Small-scale

0.458

High

1144800

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.458

High

1144803

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

273867

CNOT3
CCR4-NOT transcription complex subunit 3

1

2

High-throughput

0.445

High

1144769

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

1144804

FEM1B
Protein fem-1 homolog B

1

2

High-throughput

0.445

High

1144810

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

1122392

GIT2
ARF GTPase-activating protein GIT2

1

2

High-throughput

0.439

High

1048159

TLE4
Transducin-like enhancer protein 4

1

3

High-throughput

0.437

High

1144765

TGO1
Transport and Golgi organization protein 1 homolog

1

1

High-throughput

0.437

High

1144783

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

0

High-throughput

0.426

High

1144790

TTC1
Tetratricopeptide repeat protein 1

1

0

High-throughput

0.426

High

1144801

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

1144789

MIA2
Melanoma inhibitory activity protein 2

1

1

High-throughput

0.407

High

1088667

SF3A3
Splicing factor 3A subunit 3

3

0

High-throughput

0.347

High

1144759

SF3A2
Splicing factor 3A subunit 2

3

0

High-throughput

0.347

High

1144762

VPS72
Vacuolar protein sorting-associated protein 72 homolog

3

0

High-throughput

0.347

High

1144772

SRCAP
Helicase SRCAP

3

0

High-throughput

0.347

High

1144775

I2BP1
Interferon regulatory factor 2-binding protein 1

3

0

High-throughput

0.347

High

1144794

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

3

0

High-throughput

0.347

High

1144796

ADNP
Activity-dependent neuroprotector homeobox protein

3

0

High-throughput

0.347

High

1144785

P66B
Transcriptional repressor p66-beta

2

0

High-throughput

0.328

High

1144770

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.316

High

1144802

NLGN3
Neuroligin-3

1

0

Small-scale

0.299

High

175687

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.279

Low

1127904

GBX1
Homeobox protein GBX-1

1

0

High-throughput

0.279

Low

1144761

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

High-throughput

0.279

Low

1144779

MPND
MPN domain-containing protein

1

0

High-throughput

0.279

Low

1144777

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

0

High-throughput

0.249

Low

653330

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

689826

CD27
CD27 antigen

1

0

High-throughput

0.232

Low

885531

PRI1
DNA primase small subunit

1

0

High-throughput

0.232

Low

885579

PRI2
DNA primase large subunit

1

0

High-throughput

0.232

Low

1103967

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1144780

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.232

Low

1144784

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

1144812

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025