Protein: HPF1
Histone PARylation factor 1

Gene: HPF1
Organism: Homo sapiens
Interactions: 49
UniProt ID: Q9NWY4

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0006281 - DNA repair
GO:0006302 - double-strand break repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

487816

PARP1
Poly [ADP-ribose] polymerase 1

2

1

Small-scale

0.812

High

1451569

PARP2
Poly [ADP-ribose] polymerase 2

2

1

Small-scale

0.812

High

1162059

H31T
Histone H3.1t

2

2

Small-scale

0.595

High

1451566

HPF1
Histone PARylation factor 1

1

0

High-throughput

0.586

High

595614

H15
Histone H1.5

2

0

Small-scale

0.577

High

436745

KPCB
Protein kinase C beta type

2

0

High-throughput

0.547

High

1048229

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

1395777

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

High-throughput

0.513

High

137488

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

1

Small-scale

0.501

High

426585

HMGN2
Non-histone chromosomal protein HMG-17

1

1

Small-scale

0.501

High

981137

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

Small-scale

0.501

High

998873

H31
Histone H3.1

1

2

Small-scale

0.501

High

1017254

H33
Histone H3.3

1

2

Small-scale

0.501

High

424464

HMGN1
Non-histone chromosomal protein HMG-14

1

0

Small-scale

0.480

High

455879

H10
Histone H1.0

1

0

Small-scale

0.480

High

481395

HMGB1
High mobility group protein B1

1

0

Small-scale

0.480

High

601882

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.480

High

1451572

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

277833

H2AY
Core histone macro-H2A.1

1

1

Small-scale

0.479

High

1163246

H2B2E
Histone H2B type 2-E

1

1

Small-scale

0.479

High

941283

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.460

High

243108

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

879532

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

980437

H4
Histone H4

1

0

Small-scale

0.458

High

1032055

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1162909

H2A2C
Histone H2A type 2-C

1

0

Small-scale

0.458

High

1451567

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1451568

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1103034

CENPR
Centromere protein R

1

0

High-throughput

0.438

High

626377

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

896462

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

870083

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.328

High

1451570

MKLN1
Muskelin

2

0

High-throughput

0.319

High

387908

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.279

Low

1201336

OCAD2
OCIA domain-containing protein 2

1

0

High-throughput

0.269

Low

412700

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1255803

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

947063

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

248954

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

437808

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

466982

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low

608000

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

0

High-throughput

0.232

Low

1030222

IL5RA
Interleukin-5 receptor subunit alpha

1

0

High-throughput

0.232

Low

1239317

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1325796

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.232

Low

1366269

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

1431266

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.232

Low

1451571

STRP2
Striatin-interacting protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025