Protein: HMGN1
Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1)

Gene: HMGN1
Organism: Homo sapiens
Interactions: 165
UniProt ID: P05114

Gene Ontology (top 5):
GO:0000720 - pyrimidine dimer repair by nucleotide-excision repair
GO:0000785 - chromatin
GO:0001674 - female germ cell nucleus
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

424444

H2B1H
Histone H2B type 1-H

3

8

High-throughput

0.650

High

424383

H4
Histone H4

3

1

High-throughput

0.640

High

424384

H2B1C
Histone H2B type 1-C/E/F/G/I

3

8

High-throughput

0.640

High

424354

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

2

1

Small-scale

0.619

High

424474

RL36
Large ribosomal subunit protein eL36

3

0

High-throughput

0.613

High

424391

MDM2
E3 ubiquitin-protein ligase Mdm2

2

0

Small-scale

0.592

High

424379

H2B1D
Histone H2B type 1-D

2

8

High-throughput

0.584

High

424463

RHG35
Rho GTPase-activating protein 35

2

2

High-throughput

0.571

High

424333

HMGN2
Non-histone chromosomal protein HMG-17

2

0

High-throughput

0.559

High

354880

CHK2
Serine/threonine-protein kinase Chk2

1

2

High-throughput

0.541

High

424385

1433Z
14-3-3 protein zeta/delta

1

0

Small-scale

0.537

High

180659

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.536

High

424338

ARAF
Serine/threonine-protein kinase A-Raf

1

2

High-throughput

0.536

High

424346

BRAF
Serine/threonine-protein kinase B-raf

1

2

High-throughput

0.536

High

424347

H2AX
Histone H2AX

1

5

High-throughput

0.536

High

424375

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

424436

ANKK1
Ankyrin repeat and protein kinase domain-containing protein 1

1

3

High-throughput

0.536

High

424439

ANR49
Ankyrin repeat domain-containing protein 49

1

4

High-throughput

0.536

High

424442

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

1

High-throughput

0.536

High

424450

RSF1
Remodeling and spacing factor 1

1

1

High-throughput

0.536

High

424452

H4G
Histone H4-like protein type G

1

1

High-throughput

0.536

High

424469

PARP2
Poly [ADP-ribose] polymerase 2

1

1

High-throughput

0.536

High

424471

KS6A6
Ribosomal protein S6 kinase alpha-6

1

2

High-throughput

0.536

High

424473

AKT3
RAC-gamma serine/threonine-protein kinase

1

2

High-throughput

0.536

High

424411

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.529

High

424430

ARHGJ
Rho guanine nucleotide exchange factor 19

2

4

High-throughput

0.521

High

424413

NFE2
Transcription factor NF-E2 45 kDa subunit

1

0

High-throughput

0.518

High

418775

H2A1B
Histone H2A type 1-B/E

1

4

High-throughput

0.515

High

424377

H2BFS
Histone H2B type F-S

1

8

High-throughput

0.515

High

424415

H2B2F
Histone H2B type 2-F

1

8

High-throughput

0.515

High

424449

H2A1H
Histone H2A type 1-H

1

4

High-throughput

0.515

High

334661

IPO7
Importin-7

1

0

High-throughput

0.513

High

352289

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.513

High

424343

MYH6
Myosin-6

1

0

High-throughput

0.513

High

424368

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

High-throughput

0.513

High

424392

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

424434

KDM8
Bifunctional peptidase and arginyl-hydroxylase JMJD5

1

0

High-throughput

0.513

High

424440

ATRIP
ATR-interacting protein

1

0

High-throughput

0.513

High

424448

ADAT3
Probable inactive tRNA-specific adenosine deaminase-like protein 3

1

0

High-throughput

0.513

High

424455

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.513

High

424465

ARP3B
Actin-related protein 3B

1

0

High-throughput

0.513

High

424337

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.501

High

424349

KPCA
Protein kinase C alpha type

1

1

Small-scale

0.501

High

424373

KS6A3
Ribosomal protein S6 kinase alpha-3

1

2

Small-scale

0.501

High

424395

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.501

High

424366

MAGA4
Melanoma-associated antigen 4

1

0

High-throughput

0.493

High

424431

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.493

High

424447

ZN653
Zinc finger protein 653

1

0

High-throughput

0.493

High

424472

PLAL2
Zinc finger protein PLAGL2

1

0

High-throughput

0.493

High

424401

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

1

High-throughput

0.489

High

424370

GSK3A
Glycogen synthase kinase-3 alpha

1

0

High-throughput

0.486

High

424332

HMGN1
Non-histone chromosomal protein HMG-14

1

0

Small-scale

0.480

High

424380

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

424464

HPF1
Histone PARylation factor 1

1

0

Small-scale

0.480

High

176927

CE290
Centrosomal protein of 290 kDa

1

2

High-throughput

0.479

High

256733

H2B1K
Histone H2B type 1-K

1

8

High-throughput

0.479

High

259294

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

277510

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.479

High

283009

PSIP1
PC4 and SFRS1-interacting protein

1

1

High-throughput

0.479

High

400104

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

424334

H2B1J
Histone H2B type 1-J

1

8

High-throughput

0.479

High

424362

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.479

High

424363

PRDX2
Peroxiredoxin-2

1

1

High-throughput

0.479

High

424374

HDGF
Hepatoma-derived growth factor

1

1

High-throughput

0.479

High

424386

H31
Histone H3.1

1

3

High-throughput

0.479

High

424388

H33
Histone H3.3

1

3

High-throughput

0.479

High

424389

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

1

3

High-throughput

0.479

High

424394

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.479

High

424397

ARHG5
Rho guanine nucleotide exchange factor 5

1

4

High-throughput

0.479

High

424407

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.479

High

424410

RBP1
RalA-binding protein 1

1

3

High-throughput

0.479

High

424424

H32
Histone H3.2

1

3

High-throughput

0.479

High

424425

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.479

High

424426

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

1

2

High-throughput

0.479

High

424429

H2A2B
Histone H2A type 2-B

1

4

High-throughput

0.479

High

424432

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

424443

H2A1C
Histone H2A type 1-C

1

4

High-throughput

0.479

High

424445

H2B1A
Histone H2B type 1-A

1

8

High-throughput

0.479

High

424454

H2B1L
Histone H2B type 1-L

1

8

High-throughput

0.479

High

424458

ASXL3
Putative Polycomb group protein ASXL3

1

1

High-throughput

0.479

High

424459

RHG39
Rho GTPase-activating protein 39

1

2

High-throughput

0.479

High

424398

ANK3
Ankyrin-3

1

1

High-throughput

0.470

High

424365

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

Small-scale

0.460

High

424371

DNLI4
DNA ligase 4

1

0

High-throughput

0.460

High

162313

PDCD5
Programmed cell death protein 5

1

0

High-throughput

0.458

High

222632

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

330564

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

361052

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

424335

PROF1
Profilin-1

1

0

High-throughput

0.458

High

424336

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

424339

H14
Histone H1.4

1

0

High-throughput

0.458

High

424342

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.458

High

424345

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

424348

STMN1
Stathmin

1

0

High-throughput

0.458

High

424351

PGAM1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

424352

PTMS
Parathymosin

1

0

High-throughput

0.458

High

424353

FLNA
Filamin-A

1

0

High-throughput

0.458

High

424355

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.458

High

424356

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

424357

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

424358

CALR
Calreticulin

1

0

High-throughput

0.458

High

424359

TKT
Transketolase

1

0

High-throughput

0.458

High

424360

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

424361

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

424364

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

424367

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

424372

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

424376

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

424381

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.458

High

424382

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

424387

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.458

High

424390

VIGLN
Vigilin

1

0

High-throughput

0.458

High

424393

ERCC6
DNA excision repair protein ERCC-6

1

0

Small-scale

0.458

High

424396

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

0

High-throughput

0.458

High

424400

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

424402

ERCC8
DNA excision repair protein ERCC-8

1

0

Small-scale

0.458

High

424403

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

424404

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.458

High

424405

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

424406

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.458

High

424412

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

0

High-throughput

0.458

High

424414

MIDN
Midnolin

1

0

High-throughput

0.458

High

424421

ALKB5
RNA demethylase ALKBH5

1

0

High-throughput

0.458

High

424423

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

424433

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

424437

ZC3HF
Zinc finger CCCH domain-containing protein 15

1

0

High-throughput

0.458

High

424441

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

0

High-throughput

0.458

High

424446

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

424451

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.458

High

424457

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

424468

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

424470

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.458

High

354496

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.445

High

424378

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

424417

H37
Histone H3-7

1

3

High-throughput

0.445

High

156837

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.437

High

424344

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.437

High

424408

EEA1
Early endosome antigen 1

1

2

High-throughput

0.437

High

424416

RHG21
Rho GTPase-activating protein 21

1

2

High-throughput

0.437

High

424419

ARHGG
Rho guanine nucleotide exchange factor 16

1

4

High-throughput

0.437

High

424420

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

424422

RHG36
Rho GTPase-activating protein 36

1

3

High-throughput

0.437

High

424460

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

424462

TRPV5
Transient receptor potential cation channel subfamily V member 5

1

1

High-throughput

0.437

High

424466

RHG23
Rho GTPase-activating protein 23

1

3

High-throughput

0.437

High

424341

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

424369

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

424409

PDK1
[Pyruvate dehydrogenase

2

0

High-throughput

0.328

High

424453

S38A3
Sodium-coupled neutral amino acid transporter 3

1

0

High-throughput

0.282

High

329498

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.279

Low

424350

EGLN
Endoglin

1

0

High-throughput

0.279

Low

424418

OBSCN
Obscurin

1

0

High-throughput

0.279

Low

424427

MILR1
Allergin-1

1

0

High-throughput

0.279

Low

424435

KLH36
Kelch-like protein 36

1

0

High-throughput

0.279

Low

424438

F216A
Protein FAM216A

1

0

High-throughput

0.279

Low

424467

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.279

Low

61016

DCD2B
Doublecortin domain-containing protein 2B

1

0

High-throughput

0.269

Low

424399

LCP2
Lymphocyte cytosolic protein 2

1

0

High-throughput

0.269

Low

424456

RFIP5
Rab11 family-interacting protein 5

1

0

High-throughput

0.269

Low

424475

CCG2
Voltage-dependent calcium channel gamma-2 subunit

1

0

High-throughput

0.269

Low

424340

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

365262

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.249

Low

424428

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

424461

NGB
Neuroglobin

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025