Protein: DHSO
Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9)

Gene: DHSO, SORD
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q00796

Gene Ontology (top 5):
GO:0000721 - (R,R)-butanediol dehydrogenase activity
GO:0003939 - L-iditol 2-dehydrogenase (NAD+) activity
GO:0005615 - extracellular space
GO:0005829 - cytosol
GO:0006006 - glucose metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1027328

DHSO
Sorbitol dehydrogenase

6

15

High-throughput

0.943

High

1027352

PRR11
Proline-rich protein 11

3

0

High-throughput

0.638

High

241417

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

1027349

SERB1
SERPINE1 mRNA-binding protein 1

2

1

High-throughput

0.584

High

1027329

KPCE
Protein kinase C epsilon type

2

1

High-throughput

0.571

High

1027337

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

1027330

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

934472

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.515

High

608250

EGLN
Endoglin

1

0

High-throughput

0.513

High

772747

MYH9
Myosin-9

1

0

High-throughput

0.513

High

1027357

ANLN
Anillin

1

0

High-throughput

0.513

High

1027359

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.513

High

1027334

KLF9
Krueppel-like factor 9

1

0

High-throughput

0.479

High

353252

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

488772

FURIN
Furin

1

1

High-throughput

0.479

High

507847

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.479

High

695230

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

986345

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

986992

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

5

High-throughput

0.479

High

987331

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

5

High-throughput

0.479

High

1027332

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1027344

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1027362

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

407804

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

1027331

TF65
Transcription factor p65

1

0

High-throughput

0.460

High

164315

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

377206

SOMA
Somatotropin

1

0

High-throughput

0.458

High

377539

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

612977

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

762299

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

774291

BASI
Basigin

1

0

High-throughput

0.458

High

785819

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

1027333

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1027335

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1027348

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1027350

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1027354

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1027355

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1027363

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.458

High

142324

PEX7
Peroxisomal targeting signal 2 receptor

1

1

High-throughput

0.445

High

1027342

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

1027343

NBEL2
Neurobeachin-like protein 2

1

1

High-throughput

0.445

High

1027364

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

259804

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.437

High

588481

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

767973

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1027356

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

598724

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1027339

CTL4
Choline transporter-like protein 4

1

0

High-throughput

0.426

High

1027340

S45A4
Solute carrier family 45 member 4

1

0

High-throughput

0.426

High

1027345

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

1027347

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.426

High

1027351

S39AD
Zinc transporter ZIP13

1

0

High-throughput

0.426

High

1027358

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

1027360

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1027338

SV2C
Synaptic vesicle glycoprotein 2C

1

1

High-throughput

0.407

High

1027346

TTC9C
Tetratricopeptide repeat protein 9C

1

1

High-throughput

0.407

High

1027341

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

1027361

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

371780

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

411749

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1027336

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.249

Low

261154

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

330119

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1027353

S6A18
Inactive sodium-dependent neutral amino acid transporter B(0)AT3

1

0

High-throughput

0.232

Low

886757

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.213

Low


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Last updated: 11Aug2025