Protein: SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1)

Gene: SAMH1, SAMHD1
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q9Y3Z3

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0003676 - nucleic acid binding
GO:0003697 - single-stranded DNA binding
GO:0003723 - RNA binding
GO:0004540 - RNA nuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1491307

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

4

0

Small-scale

0.862

High

629179

CCNA2
Cyclin-A2

6

1

Small-scale

0.730

High

668084

CDK2
Cyclin-dependent kinase 2

4

1

Small-scale

0.694

High

1491309

DCAF1
DDB1- and CUL4-associated factor 1

4

1

Small-scale

0.692

High

443571

CDK1
Cyclin-dependent kinase 1

4

1

Small-scale

0.680

High

833703

NAA10
N-alpha-acetyltransferase 10

3

0

High-throughput

0.634

High

891370

GSK3A
Glycogen synthase kinase-3 alpha

2

2

High-throughput

0.628

High

891907

GSK3B
Glycogen synthase kinase-3 beta

2

2

High-throughput

0.628

High

1406816

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.618

High

1114732

CUL3
Cullin-3

2

3

High-throughput

0.611

High

1144510

NONO
Non-POU domain-containing octamer-binding protein

2

0

Small-scale

0.598

High

1359651

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

Small-scale

0.589

High

831698

CCNF
Cyclin-F

2

2

High-throughput

0.584

High

564602

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

944114

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.575

High

946682

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

High-throughput

0.561

High

168003

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.561

High

177969

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

2

Small-scale

0.561

High

243376

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1158007

DDB1
DNA damage-binding protein 1

2

0

Small-scale

0.559

High

623605

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.554

High

1433489

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.553

High

1209834

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

1

High-throughput

0.552

High

996403

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.549

High

1371797

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.537

High

326803

DUS14
Dual specificity protein phosphatase 14

1

1

High-throughput

0.536

High

1113037

CUL2
Cullin-2

1

3

High-throughput

0.536

High

1272603

CSN6
COP9 signalosome complex subunit 6

1

1

High-throughput

0.536

High

1371908

CUL5
Cullin-5

1

3

High-throughput

0.536

High

1491308

MTCL1
Microtubule cross-linking factor 1

1

1

High-throughput

0.536

High

297380

DYSF
Dysferlin

1

0

High-throughput

0.518

High

1461725

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.517

High

124856

AIP
AH receptor-interacting protein

1

0

High-throughput

0.513

High

718065

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.513

High

1040002

AKA12
A-kinase anchor protein 12

1

0

High-throughput

0.513

High

1100745

STX3
Syntaxin-3

1

0

High-throughput

0.513

High

1150855

SF01
Splicing factor 1

1

0

High-throughput

0.513

High

1158095

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

0

High-throughput

0.513

High

1194679

HSF5
Heat shock factor protein 5

1

0

High-throughput

0.513

High

1243603

RSBNL
Lysine-specific demethylase RSBN1L

1

0

High-throughput

0.513

High

1286488

DSG4
Desmoglein-4

1

0

High-throughput

0.513

High

1295051

TMM25
Transmembrane protein 25

1

0

High-throughput

0.513

High

1310557

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1395319

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.513

High

1405269

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

0

High-throughput

0.513

High

1417704

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

1430104

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.513

High

1431024

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1432206

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

0

High-throughput

0.513

High

1437443

ZMAT3
Zinc finger matrin-type protein 3

1

0

High-throughput

0.513

High

1454742

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.513

High

1491310

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.513

High

1491311

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

1491313

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.513

High

1349790

FBX25
F-box only protein 25

1

1

Small-scale

0.501

High

322884

MTCL2
Microtubule cross-linking factor 2

1

1

High-throughput

0.489

High

1333821

RDH13
Retinol dehydrogenase 13

1

1

High-throughput

0.489

High

1460227

TSP50
Probable threonine protease PRSS50

1

1

High-throughput

0.489

High

423517

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

953206

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.480

High

964520

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

1491244

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

96801

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

390974

TRFE
Serotransferrin

1

1

Small-scale

0.479

High

391110

TRFL
Lactotransferrin

1

1

Small-scale

0.479

High

412863

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

487914

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

963552

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

High-throughput

0.479

High

1007663

CCNA1
Cyclin-A1

1

1

Small-scale

0.479

High

1040953

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

1100575

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1115163

CUL4A
Cullin-4A

1

3

Small-scale

0.479

High

1121386

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

1168932

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

1

Small-scale

0.479

High

1220905

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1256230

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1370770

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

1

High-throughput

0.479

High

1380284

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1380695

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1385412

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

1402455

CCNL2
Cyclin-L2

1

1

Small-scale

0.479

High

1404867

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1420911

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

1

High-throughput

0.479

High

1437891

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

1453190

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1461017

FBW1B
F-box/WD repeat-containing protein 11

1

1

Small-scale

0.479

High

1462092

UBP18
Ubl carboxyl-terminal hydrolase 18

1

1

Small-scale

0.479

High

1491315

NEMO
NF-kappa-B essential modulator

1

1

Small-scale

0.479

High

1491316

DUS10
Dual specificity protein phosphatase 10

1

2

High-throughput

0.479

High

158366

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

214080

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.458

High

350196

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

364076

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

369939

CO3
Complement C3

1

0

Small-scale

0.458

High

401752

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

405363

OAT
Ornithine aminotransferase, mitochondrial

1

0

Small-scale

0.458

High

475081

VIME
Vimentin

1

0

Small-scale

0.458

High

538163

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

607262

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

620674

NUCL
Nucleolin

1

0

Small-scale

0.458

High

685788

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.458

High

688197

EF1G
Elongation factor 1-gamma

1

0

Small-scale

0.458

High

696950

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

715000

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.458

High

731728

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

766973

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

769595

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

907636

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

911169

IMA1
Importin subunit alpha-1

1

0

Small-scale

0.458

High

926702

HIRA
Protein HIRA

1

0

Small-scale

0.458

High

935335

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

948970

CD81
CD81 antigen

1

0

High-throughput

0.458

High

969094

PRS8
26S proteasome regulatory subunit 8

1

0

Small-scale

0.458

High

971345

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

984035

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

986831

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

Small-scale

0.458

High

997202

TBA4A
Tubulin alpha-4A chain

1

0

Small-scale

0.458

High

1045943

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1047152

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

Small-scale

0.458

High

1098179

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

1101936

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

1107367

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1119049

BYST
Bystin

1

0

Small-scale

0.458

High

1134443

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

1155941

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1161451

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

1187992

GON4L
GON-4-like protein

1

0

Small-scale

0.458

High

1218711

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1229793

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1249358

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1277016

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1322475

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

1323594

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1339773

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1368220

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1385666

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1385934

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1387182

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

Small-scale

0.458

High

1397593

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1406600

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

1415918

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1418549

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1429415

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1431359

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1434312

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1435488

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1446459

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1459163

ABCF2
ATP-binding cassette sub-family F member 2

1

0

Small-scale

0.458

High

1459428

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1461478

DNPEP
Aspartyl aminopeptidase

1

0

Small-scale

0.458

High

1491312

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.458

High

116917

J3KMX2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2

1

1

High-throughput

0.445

High

650505

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.445

High

1212395

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.445

High

1310987

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.445

High

1406757

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

1

1

High-throughput

0.445

High

1430373

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

1452562

FA13B
Protein FAM13B

1

2

Small-scale

0.439

High

1491314

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

2

High-throughput

0.437

High

259185

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.426

High

378304

IFN21
Interferon alpha-21

1

0

High-throughput

0.426

High

437843

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

1029179

E2F1
Transcription factor E2F1

1

0

High-throughput

0.426

High

1181454

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

1227763

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1391881

AURKB
Aurora kinase B

1

0

High-throughput

0.426

High

1420777

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1434778

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.426

High

1449285

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

104302

F5H6I0
Beta-2-microglobulin

1

1

High-throughput

0.407

High

628479

KLK2
Kallikrein-2

1

1

High-throughput

0.407

High

1428435

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.407

High

1433255

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

2

High-throughput

0.407

High

1349153

F174A
Membrane protein FAM174A

2

0

High-throughput

0.313

High

1034852

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

1063903

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.279

Low

1098695

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

1105597

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

212041

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

0

Small-scale

0.249

Low

294576

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

369416

A1AT
Alpha-1-antitrypsin

1

0

Small-scale

0.249

Low

377798

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

646968

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

Small-scale

0.249

Low

955871

DEST
Destrin

1

0

Small-scale

0.249

Low

1275893

NRK
Nik-related protein kinase

1

0

Small-scale

0.249

Low

1450983

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

Small-scale

0.249

Low

1169

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

116494

H7C0N4
Splicing factor 1

1

0

High-throughput

0.232

Low

1034548

TAGL
Transgelin

1

0

High-throughput

0.232

Low

1253217

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1416666

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

0

High-throughput

0.232

Low

1419172

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025