Protein: SYFA
Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)

Gene: SYFA, FARSA
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q9Y285

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004826 - phenylalanine-tRNA ligase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1345537

SYFB
Phenylalanine--tRNA ligase beta subunit

7

8

Small-scale

0.968

High

370745

ESR1
Estrogen receptor

3

1

Small-scale

0.641

High

229096

PRKN
E3 ubiquitin-protein ligase parkin

3

4

High-throughput

0.640

High

1042870

CUL3
Cullin-3

2

2

High-throughput

0.611

High

850241

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

2

High-throughput

0.601

High

1355741

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

0

High-throughput

0.595

High

818625

SOX2
Transcription factor SOX-2

2

1

High-throughput

0.584

High

1313010

PDC10
Programmed cell death protein 10

2

0

High-throughput

0.580

High

1334253

COG4
Conserved oligomeric Golgi complex subunit 4

2

0

High-throughput

0.580

High

1350203

ABI3
ABI gene family member 3

1

2

High-throughput

0.573

High

375112

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.571

High

1119969

RHG29
Rho GTPase-activating protein 29

2

1

High-throughput

0.571

High

780347

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

1349041

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.559

High

272769

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

592589

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

1309256

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.543

High

1041290

CUL1
Cullin-1

1

2

High-throughput

0.536

High

1085551

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.536

High

497834

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.528

High

1169995

RHG36
Rho GTPase-activating protein 36

2

1

High-throughput

0.521

High

1135003

GORAB
RAB6-interacting golgin

1

0

High-throughput

0.518

High

1244191

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

2

High-throughput

0.515

High

207129

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

585591

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

813857

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

175316

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

890898

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.480

High

131113

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

302696

ARHGF
Rho guanine nucleotide exchange factor 15

1

1

High-throughput

0.479

High

323329

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

326827

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

476592

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.479

High

487859

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

542933

BRAF
Serine/threonine-protein kinase B-raf

1

1

High-throughput

0.479

High

548765

VAV
Proto-oncogene vav

1

2

High-throughput

0.479

High

719244

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

782013

PERI
Peripherin

1

1

High-throughput

0.479

High

870937

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

1030036

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1054114

GRB7
Growth factor receptor-bound protein 7

1

2

Small-scale

0.479

High

1108749

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.479

High

1119521

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

1136363

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1146975

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1172323

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1266438

TCPW
T-complex protein 1 subunit zeta-2

1

2

High-throughput

0.479

High

1330888

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

1331662

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1335243

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1350009

RHG23
Rho GTPase-activating protein 23

1

1

High-throughput

0.479

High

1354904

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1356936

PKHG1
Pleckstrin homology domain-containing family G member 1

1

2

High-throughput

0.479

High

1357202

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

1377100

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.479

High

1377103

ASB4
Ankyrin repeat and SOCS box protein 4

1

2

High-throughput

0.479

High

331357

CHK2
Serine/threonine-protein kinase Chk2

1

0

Small-scale

0.464

High

361541

APOE
Apolipoprotein E

1

0

High-throughput

0.460

High

1327393

RNF32
RING finger protein 32

1

0

High-throughput

0.460

High

117463

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

119572

LEG9
Galectin-9

1

0

High-throughput

0.458

High

125803

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

Small-scale

0.458

High

295420

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298899

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

303544

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

339160

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

385746

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

387767

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

409280

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

514102

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

529933

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

570196

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

583634

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

658455

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

717447

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

719661

MERL
Merlin

1

0

High-throughput

0.458

High

750545

COIL
Coilin

1

0

High-throughput

0.458

High

786199

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

807886

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

832790

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

909347

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

916084

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.458

High

970079

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1026386

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1027829

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.458

High

1036218

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1037013

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1045237

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

1054681

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1064855

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1078380

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

1156426

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

1168753

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1199719

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

1201776

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1268985

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1281882

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1294144

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1302792

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

1310227

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.458

High

1319141

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1330566

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1332792

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1342848

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1343393

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1343815

ANLN
Anillin

1

0

High-throughput

0.458

High

1344622

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1347325

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1354167

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

1377102

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

402642

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

587757

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

High-throughput

0.445

High

883675

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

1130741

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1169448

NBEL2
Neurobeachin-like protein 2

1

1

High-throughput

0.445

High

202326

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

0

High-throughput

0.438

High

245111

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

441795

CFAH
Complement factor H

1

1

Small-scale

0.437

High

781488

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.437

High

962573

ECT2L
Epithelial cell-transforming sequence 2 oncogene-like

1

3

High-throughput

0.437

High

1176288

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

1220842

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.437

High

1233866

ARG39
Rho guanine nucleotide exchange factor 39

1

3

High-throughput

0.437

High

1283491

MFRN2
Mitoferrin-2

1

1

High-throughput

0.437

High

1301008

CIC
Protein capicua homolog

1

1

High-throughput

0.437

High

1357010

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

331116

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

718336

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

905275

1433G
14-3-3 protein gamma

1

0

High-throughput

0.426

High

1057729

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1233272

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1291613

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

1128907

Q5JYA6
PLEKHG1

1

2

High-throughput

0.407

High

344598

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.282

High

526928

TDGF1
Protein Cripto

1

0

High-throughput

0.282

High

452923

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

678108

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

1328643

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.269

Low

165887

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.249

Low

182960

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

352315

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

541300

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

554091

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

652644

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

721817

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

824551

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

903618

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1053695

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1138644

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

1152200

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1166081

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1189065

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1252249

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1327157

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1349393

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

1377101

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1168

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

1169476

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1241684

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024