Protein: ARPC3
Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)

Gene: ARPC3
Organism: Homo sapiens
Interactions: 174
UniProt ID: O15145

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005885 - Arp2/3 protein complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

179491

ARP2
Actin-related protein 2

13

7

High-throughput

0.981

High

179490

ARP3
Actin-related protein 3

13

8

Small-scale

0.978

High

179574

ARP3B
Actin-related protein 3B

7

8

High-throughput

0.966

High

179270

ARPC2
Actin-related protein 2/3 complex subunit 2

9

2

Small-scale

0.751

High

179093

ARC1B
Actin-related protein 2/3 complex subunit 1B

8

5

Small-scale

0.751

High

179423

ARPC5
Actin-related protein 2/3 complex subunit 5

7

3

Small-scale

0.750

High

179548

ARC1A
Actin-related protein 2/3 complex subunit 1A

7

5

Small-scale

0.749

High

179487

ARPC4
Actin-related protein 2/3 complex subunit 4

7

5

Small-scale

0.749

High

179558

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

6

3

Small-scale

0.735

High

179488

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.691

High

179498

ACTG
Actin, cytoplasmic 2

1

3

High-throughput

0.691

High

133607

WASL
Actin nucleation-promoting factor WASL

3

4

High-throughput

0.675

High

179538

DOCK8
Dedicator of cytokinesis protein 8

3

1

High-throughput

0.667

High

179554

DOCK7
Dedicator of cytokinesis protein 7

3

1

High-throughput

0.667

High

179471

WASP
Actin nucleation-promoting factor WAS

3

5

Small-scale

0.661

High

179424

HXA3
Homeobox protein Hox-A3

3

0

High-throughput

0.646

High

179444

GALT
Galactose-1-phosphate uridylyltransferase

3

0

High-throughput

0.638

High

179567

ANLN
Anillin

3

0

High-throughput

0.628

High

179499

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.618

High

179501

GOGA2
Golgin subfamily A member 2

3

3

High-throughput

0.616

High

179508

SRC8
Src substrate cortactin

2

1

Small-scale

0.611

High

179523

DUS29
Dual specificity phosphatase 29

2

1

High-throughput

0.606

High

179565

ZN576
Zinc finger protein 576

2

1

High-throughput

0.606

High

179511

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

1

High-throughput

0.586

High

60479

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

0

High-throughput

0.580

High

179434

LATS1
Serine/threonine-protein kinase LATS1

2

0

High-throughput

0.580

High

179455

PO2F1
POU domain, class 2, transcription factor 1

2

0

High-throughput

0.580

High

179458

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.576

High

179441

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

179473

CCR10
C-C chemokine receptor type 10

2

1

High-throughput

0.553

High

179478

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.549

High

179431

SH3L1
Adapter SH3BGRL

2

0

High-throughput

0.547

High

179472

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

1

High-throughput

0.541

High

123510

MYO1C
Unconventional myosin-Ic

1

5

High-throughput

0.536

High

179466

1433B
14-3-3 protein beta/alpha

1

3

High-throughput

0.536

High

179475

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.536

High

179476

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

179477

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

179497

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.536

High

179500

CALD1
Caldesmon

1

4

High-throughput

0.536

High

179527

BCOR
BCL-6 corepressor

1

1

High-throughput

0.536

High

179531

PIM3
Serine/threonine-protein kinase pim-3

1

1

High-throughput

0.536

High

179546

MY18A
Unconventional myosin-XVIIIa

1

1

High-throughput

0.536

High

179552

MYO19
Unconventional myosin-XIX

1

2

High-throughput

0.536

High

179568

MYO5C
Unconventional myosin-Vc

1

2

High-throughput

0.536

High

179474

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.518

High

179486

LEG4
Galectin-4

1

0

High-throughput

0.518

High

179555

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.518

High

179557

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.518

High

179443

CATB
Cathepsin B

1

2

High-throughput

0.515

High

179581

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.515

High

179425

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

High-throughput

0.513

High

179439

FINC
Fibronectin

1

0

High-throughput

0.513

High

179460

FLNA
Filamin-A

1

0

High-throughput

0.513

High

179462

CXCR2
C-X-C chemokine receptor type 2

1

0

Small-scale

0.513

High

179469

MYH9
Myosin-9

1

0

High-throughput

0.513

High

179470

MNDA
Myeloid cell nuclear differentiation antigen

1

0

High-throughput

0.513

High

179483

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.513

High

179494

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

179507

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

179514

DREB
Drebrin

1

0

High-throughput

0.513

High

179519

CL16A
Protein CLEC16A

1

0

High-throughput

0.513

High

179535

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

179551

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

179569

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.513

High

179575

STK26
Serine/threonine-protein kinase 26

1

0

High-throughput

0.513

High

179580

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.513

High

179516

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.508

High

179464

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.493

High

126370

RHOD
Rho-related GTP-binding protein RhoD

1

1

High-throughput

0.479

High

142718

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.479

High

176907

CE290
Centrosomal protein of 290 kDa

1

3

High-throughput

0.479

High

179432

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

179433

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

179442

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

179445

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

179454

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

179456

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

179457

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

179481

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

179503

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

179504

DUS8
Dual specificity protein phosphatase 8

1

1

High-throughput

0.479

High

179518

DUS6
Dual specificity protein phosphatase 6

1

2

High-throughput

0.479

High

179539

BICD2
Protein bicaudal D homolog 2

1

3

High-throughput

0.479

High

179543

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.479

High

179547

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

179549

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

179563

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

179579

TES
Testin

1

1

High-throughput

0.479

High

179544

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.470

High

179495

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

Small-scale

0.460

High

156702

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

164178

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

172266

XPO1
Exportin-1

1

0

High-throughput

0.458

High

179422

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.458

High

179427

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

179429

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

179435

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

179437

FOS
Protein c-Fos

1

0

High-throughput

0.458

High

179438

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

179440

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

179446

FURIN
Furin

1

0

High-throughput

0.458

High

179450

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

179452

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

179459

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

179465

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

179468

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

179480

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.458

High

179482

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

179484

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

179489

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.458

High

179492

UFM1
Ubiquitin-fold modifier 1

1

0

High-throughput

0.458

High

179493

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

179502

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

179505

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

179510

CUL7
Cullin-7

1

0

High-throughput

0.458

High

179512

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

179513

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

179515

FSCN1
Fascin

1

0

High-throughput

0.458

High

179517

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

179525

ANO7
Anoctamin-7

1

0

Small-scale

0.458

High

179526

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

Small-scale

0.458

High

179540

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

179542

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

179545

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

179553

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

179559

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

179561

SIK2
Serine/threonine-protein kinase SIK2

1

0

Small-scale

0.458

High

179562

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

179566

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

179570

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.458

High

179571

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

179577

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

179578

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

46391

A0A1W2PNV4
Actin-related protein 2/3 complex subunit 1A

1

5

High-throughput

0.445

High

179448

CALM3
Calmodulin-3

1

1

High-throughput

0.445

High

179556

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.445

High

179447

LKHA4
Leukotriene A-4 hydrolase

1

0

High-throughput

0.438

High

179451

CETP
Cholesteryl ester transfer protein

1

0

High-throughput

0.438

High

179550

OTUD5
OTU domain-containing protein 5

1

0

High-throughput

0.438

High

179463

CATS
Cathepsin S

1

1

High-throughput

0.437

High

179520

PREP
Presequence protease, mitochondrial

1

1

High-throughput

0.437

High

179529

CE128
Centrosomal protein of 128 kDa

1

3

High-throughput

0.437

High

179530

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

179536

NIN
Ninein

1

3

High-throughput

0.437

High

179560

ASXL3
Putative Polycomb group protein ASXL3

1

1

High-throughput

0.437

High

179564

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

179449

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

179453

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

179467

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

179485

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

179496

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.426

High

179506

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

179573

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.426

High

179524

Q6IBM8
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.417

High

179479

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

179430

CLU
Clustered mitochondria protein homolog

3

0

High-throughput

0.347

High

179522

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

3

0

High-throughput

0.347

High

179541

CHUR
Protein Churchill

2

0

High-throughput

0.318

High

179532

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.316

High

179534

FAM9A
Protein FAM9A

2

0

High-throughput

0.316

High

179537

RB8NL
RBBP8 N-terminal-like protein

2

0

High-throughput

0.316

High

179572

SYBU
Syntabulin

2

0

High-throughput

0.316

High

65463

PCARE
Photoreceptor cilium actin regulator

1

0

High-throughput

0.279

Low

179576

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

179426

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.249

Low

179436

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

179461

FGFR4
Fibroblast growth factor receptor 4

1

0

High-throughput

0.249

Low

179509

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

179528

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

179582

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

179533

THNS2
Threonine synthase-like 2

1

0

High-throughput

0.238

Low

179428

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

179521

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025