Protein: STING
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)

Gene: STING, STING1
Organism: Homo sapiens
Interactions: 143
UniProt ID: Q86WV6

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000139 - Golgi membrane
GO:0000421 - autophagosome membrane
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1292836

STING
Stimulator of interferon genes protein

15

2

Small-scale

0.984

High

1292886

TBK1
Serine/threonine-protein kinase TBK1

29

7

Small-scale

0.768

High

1278023

MAVS
Mitochondrial antiviral-signaling protein

12

1

Small-scale

0.756

High

1129156

IRF3
Interferon regulatory factor 3

7

2

Small-scale

0.739

High

1122522

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

5

6

Small-scale

0.702

High

1093379

TRI32
E3 ubiquitin-protein ligase TRIM32

4

8

Small-scale

0.692

High

1161523

IF16
Gamma-interferon-inducible protein 16

4

0

Small-scale

0.678

High

1094924

TRAF3
TNF receptor-associated factor 3

4

6

Small-scale

0.676

High

1292883

UBP35
Ubiquitin carboxyl-terminal hydrolase 35

3

10

Small-scale

0.670

High

345089

RIGI
Antiviral innate immune response receptor RIG-I

3

5

Small-scale

0.657

High

1292868

RNF5
E3 ubiquitin-protein ligase RNF5

3

6

Small-scale

0.650

High

1292869

TRI56
E3 ubiquitin-protein ligase TRIM56

3

5

Small-scale

0.640

High

184467

SURF4
Surfeit locus protein 4

2

1

Small-scale

0.634

High

1257878

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

2

6

Small-scale

0.624

High

1292872

RNF26
E3 ubiquitin-protein ligase RNF26

2

4

Small-scale

0.624

High

1292892

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

7

Small-scale

0.624

High

1097822

STX5
Syntaxin-5

2

3

High-throughput

0.606

High

1292861

REEP6
Receptor expression-enhancing protein 6

2

3

High-throughput

0.606

High

1292882

TECR
Very-long-chain enoyl-CoA reductase

2

1

High-throughput

0.606

High

951240

SC61B
Protein transport protein Sec61 subunit beta

2

1

Small-scale

0.594

High

337764

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.586

High

813147

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.586

High

863501

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

3

High-throughput

0.586

High

1292857

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.586

High

1292864

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

2

High-throughput

0.586

High

417547

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

High-throughput

0.584

High

74176

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

329637

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.580

High

1292880

TM100
Transmembrane protein 100

2

0

High-throughput

0.580

High

1292893

PLLP
Plasmolipin

2

0

High-throughput

0.580

High

1218562

MYSM1
Deubiquitinase MYSM1

1

1

Small-scale

0.578

High

1292885

TRI10
Tripartite motif-containing protein 10

1

2

Small-scale

0.578

High

317878

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.561

High

905610

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.561

High

1292838

CCD50
Coiled-coil domain-containing protein 50

1

1

Small-scale

0.561

High

1292856

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

5

Small-scale

0.561

High

1292895

RN115
E3 ubiquitin-protein ligase RNF115

1

2

Small-scale

0.561

High

838243

STAT6
Signal transducer and activator of transcription 6

1

4

Small-scale

0.554

High

1292871

YIPF2
Protein YIPF2

2

2

High-throughput

0.553

High

65779

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

1

High-throughput

0.536

High

178317

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.536

High

339525

ACSL3
Fatty acid CoA ligase Acsl3

1

2

High-throughput

0.536

High

488128

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

1

Small-scale

0.536

High

488183

IFIT1
Antiviral innate immune response effector IFIT1

1

1

Small-scale

0.536

High

650558

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

2

High-throughput

0.536

High

753822

MRP1
Multidrug resistance-associated protein 1

1

3

High-throughput

0.536

High

884665

SYHM
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

963096

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.536

High

1139484

S39AE
Metal cation symporter ZIP14

1

2

High-throughput

0.536

High

1292842

CNNM3
Metal transporter CNNM3

1

1

High-throughput

0.536

High

1292844

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

3

High-throughput

0.536

High

1292846

SPP
Signal peptide peptidase

1

2

High-throughput

0.536

High

1292863

CLP1L
Lipid scramblase CLPTM1L

1

1

High-throughput

0.536

High

847781

SSRB
Translocon-associated protein subunit beta

1

1

Small-scale

0.526

High

222380

TSN6
Tetraspanin-6

1

1

Small-scale

0.515

High

1292865

NECT4
Nectin-4

1

2

High-throughput

0.515

High

314958

DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

1

0

High-throughput

0.513

High

762084

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.513

High

1187002

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.513

High

1197249

MBRL
Membralin

1

0

High-throughput

0.513

High

1292853

GLMN
Glomulin

1

0

High-throughput

0.513

High

1292855

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

1211888

FKB15
FK506-binding protein 15

1

1

High-throughput

0.489

High

1292843

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

1

1

High-throughput

0.489

High

167927

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

7

Small-scale

0.479

High

288456

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

Small-scale

0.479

High

318025

TOM70
Mitochondrial import receptor subunit TOM70

1

3

Small-scale

0.479

High

623415

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

Small-scale

0.479

High

683279

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

Small-scale

0.479

High

921941

COPA
Coatomer subunit alpha

1

1

Small-scale

0.479

High

1090761

TRAF2
TNF receptor-associated factor 2

1

4

Small-scale

0.479

High

1113591

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1120918

TRI29
Tripartite motif-containing protein 29

1

6

Small-scale

0.479

High

1163031

H2B2E
Histone H2B type 2-E

1

4

Small-scale

0.479

High

1197523

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

Small-scale

0.479

High

1258242

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

4

Small-scale

0.479

High

1289004

NLRX1
NLR family member X1

1

2

Small-scale

0.479

High

1292840

CGAS
Cyclic GMP-AMP synthase

1

2

Small-scale

0.479

High

1292841

DHB11
Estradiol 17-beta-dehydrogenase 11

1

6

High-throughput

0.479

High

1292845

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

1

Small-scale

0.479

High

1292848

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1292850

LMO7
LIM domain only protein 7

1

3

Small-scale

0.479

High

1292852

IRF7
Interferon regulatory factor 7

1

2

Small-scale

0.479

High

1292854

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

8

Small-scale

0.479

High

1292858

FAF2
FAS-associated factor 2

1

3

Small-scale

0.479

High

1292866

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

4

Small-scale

0.479

High

1292867

ELF4
ETS-related transcription factor Elf-4

1

1

Small-scale

0.479

High

1292870

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1292875

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.479

High

1292877

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1292887

SEPT9
Septin-9

1

2

Small-scale

0.479

High

1292888

AMFR
E3 ubiquitin-protein ligase AMFR

1

9

Small-scale

0.479

High

1292890

UBP18
Ubl carboxyl-terminal hydrolase 18

1

8

Small-scale

0.479

High

1292891

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

2

Small-scale

0.479

High

1292894

TRAF6
TNF receptor-associated factor 6

1

6

Small-scale

0.479

High

1292897

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

Small-scale

0.479

High

181135

AXIN1
Axin-1

1

0

Small-scale

0.458

High

212672

DAPK3
Death-associated protein kinase 3

1

0

Small-scale

0.458

High

257262

PQBP1
Polyglutamine-binding protein 1

1

0

Small-scale

0.458

High

414137

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

507259

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

822740

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

1292860

OTUD5
OTU domain-containing protein 5

1

0

Small-scale

0.458

High

1292876

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

599998

ZNF16
Zinc finger protein 16

1

1

Small-scale

0.457

High

178558

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

6

Small-scale

0.445

High

253164

MOT2
Monocarboxylate transporter 2

1

6

Small-scale

0.445

High

552831

TPR
Nucleoprotein TPR

1

2

Small-scale

0.445

High

611207

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

Small-scale

0.445

High

685028

DNMT1
DNA

1

1

Small-scale

0.445

High

827833

STAT3
Signal transducer and activator of transcription 3

1

4

Small-scale

0.445

High

847588

SSRA
Translocon-associated protein subunit alpha

1

1

Small-scale

0.445

High

890137

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

Small-scale

0.445

High

992242

SKP1
S-phase kinase-associated protein 1

1

1

Small-scale

0.445

High

1065966

VAC14
Protein VAC14 homolog

1

3

Small-scale

0.445

High

1131563

MFS10
Major facilitator superfamily domain-containing protein 10

1

2

High-throughput

0.445

High

1196274

GRAP1
GRIP1-associated protein 1

1

3

Small-scale

0.445

High

1258029

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

3

Small-scale

0.445

High

1292837

RBM45
RNA-binding protein 45

1

2

Small-scale

0.445

High

1292847

DDX54
ATP-dependent RNA helicase DDX54

1

3

Small-scale

0.445

High

1292873

KPCD2
Serine/threonine-protein kinase D2

1

2

Small-scale

0.445

High

1292878

EXOS5
Exosome complex component RRP46

1

2

Small-scale

0.445

High

1292889

MYO6
Unconventional myosin-VI

1

2

Small-scale

0.445

High

1292896

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

1

Small-scale

0.445

High

1292879

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

67481

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

Small-scale

0.426

High

378573

IL1B
Interleukin-1 beta

1

0

Small-scale

0.426

High

405610

HRG
Histidine-rich glycoprotein

1

0

Small-scale

0.426

High

1226991

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1292839

INT1
Integrator complex subunit 1

1

0

Small-scale

0.426

High

1292851

PRCC
Proline-rich protein PRCC

1

0

Small-scale

0.426

High

1292862

INT4
Integrator complex subunit 4

1

0

Small-scale

0.426

High

1292874

INT2
Integrator complex subunit 2

1

0

Small-scale

0.426

High

1292881

INT7
Integrator complex subunit 7

1

0

Small-scale

0.426

High

1292884

SAE1
SUMO-activating enzyme subunit 1

1

0

Small-scale

0.426

High

231805

MFS11
UNC93-like protein MFSD11

1

1

High-throughput

0.407

High

1292859

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

0

High-throughput

0.316

High

1162406

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.279

Low

1254249

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.279

Low

326152

REC8
Meiotic recombination protein REC8 homolog

1

0

Small-scale

0.249

Low

1292849

MITD1
MIT domain-containing protein 1

1

0

Small-scale

0.232

Low

1292898

Z780B
Zinc finger protein 780B

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025