Protein: PKD2
Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)

Gene: PKD2
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q13563

Gene Ontology (top 5):
GO:0001658 - branching involved in ureteric bud morphogenesis
GO:0001889 - liver development
GO:0001892 - embryonic placenta development
GO:0001947 - heart looping
GO:0002133 - polycystin complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1022579

PKD1
Polycystin-1

8

8

Small-scale

0.982

High

1110784

PKD2
Polycystin-2

7

15

Small-scale

0.980

High

878228

TRPC1
Short transient receptor potential channel 1

2

18

Small-scale

0.825

High

1110824

PK2L2
Polycystin-2-like protein 2

2

16

High-throughput

0.811

High

1110797

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

2

0

High-throughput

0.770

High

1110787

CNGA3
Cyclic nucleotide-gated channel alpha-3

1

4

High-throughput

0.691

High

1110800

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

4

High-throughput

0.691

High

1110822

PICK1
PRKCA-binding protein

3

3

High-throughput

0.667

High

1110807

BCAS4
Breast carcinoma-amplified sequence 4

3

0

High-throughput

0.638

High

1110832

ALG5
Dolichyl-phosphate beta-glucosyltransferase

3

0

High-throughput

0.638

High

1110813

FAM3D
Protein FAM3D

3

0

High-throughput

0.634

High

845508

PI2R
Prostacyclin receptor

2

1

High-throughput

0.628

High

1057542

ACHD
Acetylcholine receptor subunit delta

2

1

High-throughput

0.628

High

1110828

CRYL1
Lambda-crystallin homolog

2

1

High-throughput

0.628

High

1110793

CE170
Centrosomal protein of 170 kDa

2

9

High-throughput

0.611

High

70197

CRTP1
Cysteine-rich tail protein 1

2

2

High-throughput

0.606

High

252863

EXOC3
Exocyst complex component 3

2

0

High-throughput

0.602

High

1110799

TMPSC
Transmembrane protease serine 12

2

0

High-throughput

0.602

High

170753

CLGN
Calmegin

2

1

High-throughput

0.601

High

638190

S1PR1
Sphingosine 1-phosphate receptor 1

2

1

High-throughput

0.601

High

1110825

FBX2
F-box only protein 2

2

1

High-throughput

0.601

High

658520

GLRA2
Glycine receptor subunit alpha-2

2

0

High-throughput

0.585

High

269191

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1110790

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1110817

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

1110804

LSME2
Leucine-rich single-pass membrane protein 2

2

0

High-throughput

0.576

High

1110814

TM169
Transmembrane protein 169

2

0

High-throughput

0.576

High

1110819

CENPH
Centromere protein H

2

0

High-throughput

0.576

High

622499

TNNI3
Troponin I, cardiac muscle

1

2

Small-scale

0.573

High

950471

KR108
Keratin-associated protein 10-8

1

3

High-throughput

0.573

High

1110795

K1C40
Keratin, type I cytoskeletal 40

1

8

High-throughput

0.573

High

180515

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.549

High

248439

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

1

High-throughput

0.536

High

640385

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

1

High-throughput

0.536

High

723683

NTR1
Neurotensin receptor type 1

1

1

High-throughput

0.536

High

889273

NUMB
Protein numb homolog

1

1

High-throughput

0.536

High

1110809

RN133
E3 ubiquitin-protein ligase RNF133

1

3

High-throughput

0.536

High

1110831

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.536

High

1036512

ID2
DNA-binding protein inhibitor ID-2

1

1

Small-scale

0.529

High

67037

IFM5
Interferon-induced transmembrane protein 5

1

0

High-throughput

0.513

High

904428

CP2J2
Cytochrome P450 2J2

1

0

High-throughput

0.513

High

1013507

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.513

High

1110785

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.513

High

1110786

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1110791

CLM2
CMRF35-like molecule 2

1

0

High-throughput

0.513

High

1110792

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1110798

TMC4
Voltage-gated chloride channel TMC4

1

0

High-throughput

0.513

High

1110805

OR6T1
Olfactory receptor 6T1

1

0

High-throughput

0.513

High

1110806

LHPL5
LHFPL tetraspan subfamily member 5 protein

1

0

High-throughput

0.513

High

1110808

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.513

High

1110810

NAR4
Ecto-ADP-ribosyltransferase 4

1

0

High-throughput

0.513

High

1110811

DACT3
Dapper homolog 3

1

0

High-throughput

0.513

High

1110830

O10H1
Olfactory receptor 10H1

1

0

High-throughput

0.513

High

1110833

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.513

High

385719

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

7

High-throughput

0.481

High

659024

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

9

Small-scale

0.481

High

949868

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.481

High

218156

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

252449

DIAP1
Protein diaphanous homolog 1

1

1

Small-scale

0.479

High

469075

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.479

High

728221

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.479

High

1110801

GCC2
GRIP and coiled-coil domain-containing protein 2

1

10

High-throughput

0.479

High

1110823

TM248
Transmembrane protein 248

1

1

High-throughput

0.479

High

418110

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

1110816

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1110803

AGRG5
Adhesion G-protein coupled receptor G5

1

5

High-throughput

0.445

High

1110812

S67A1
Solute carrier family 67 member A1

1

1

High-throughput

0.445

High

1110821

FBX6
F-box only protein 6

1

1

High-throughput

0.445

High

124333

HAX1
HCLS1-associated protein X-1

1

0

Small-scale

0.438

High

1110796

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1110802

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.426

High

1110815

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High

1110818

LMA2L
VIP36-like protein

1

0

High-throughput

0.426

High

1110820

ZDH11
Palmitoyltransferase ZDHHC11

1

0

High-throughput

0.426

High

1110826

S22AE
Solute carrier family 22 member 14

1

0

High-throughput

0.426

High

1110827

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

1110794

S35F1
Solute carrier family 35 member F1

1

1

High-throughput

0.407

High

1110829

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.328

High

848482

MAGA8
Melanoma-associated antigen 8

2

0

High-throughput

0.327

High

1110788

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1110789

CO032
Uncharacterized protein C15orf32

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025