Protein: NFYA
Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA)

Gene: NFYA
Organism: Homo sapiens
Interactions: 88
UniProt ID: P23511

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

659655

NFYB
Nuclear transcription factor Y subunit beta

10

11

Small-scale

0.978

High

659679

NFYC
Nuclear transcription factor Y subunit gamma

9

20

Small-scale

0.976

High

659669

CSK21
Casein kinase II subunit alpha

4

6

High-throughput

0.705

High

413203

P53
Cellular tumor antigen p53

4

1

Small-scale

0.698

High

464813

SP1
Transcription factor Sp1

4

1

Small-scale

0.697

High

659674

EP300
Histone acetyltransferase p300

4

1

Small-scale

0.680

High

659665

TF2AA
Transcription initiation factor IIA subunit 1

4

0

High-throughput

0.668

High

659687

POGZ
Pogo transposable element with ZNF domain

3

0

High-throughput

0.646

High

659654

CDK2
Cyclin-dependent kinase 2

2

3

Small-scale

0.634

High

659711

TES
Testin

2

1

High-throughput

0.628

High

659698

ZC3HA
Zinc finger CCCH domain-containing protein 10

3

0

High-throughput

0.626

High

659712

ZHX1
Zinc fingers and homeoboxes protein 1

2

1

Small-scale

0.622

High

659693

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.613

High

659668

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

1

High-throughput

0.611

High

576165

PO2F1
POU domain, class 2, transcription factor 1

2

1

High-throughput

0.606

High

659676

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

2

0

High-throughput

0.602

High

659683

UAP1
UDP-N-acetylhexosamine pyrophosphorylase

2

0

High-throughput

0.602

High

659701

CHM4A
Charged multivesicular body protein 4a

2

0

High-throughput

0.602

High

659703

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.602

High

429315

JUN
Transcription factor Jun

2

3

Small-scale

0.584

High

659666

ATX1
Ataxin-1

2

0

High-throughput

0.580

High

659680

VEZF1
Vascular endothelial zinc finger 1

2

0

High-throughput

0.580

High

659685

QRIC1
Transcriptional regulator QRICH1

2

0

High-throughput

0.580

High

659690

BANP
Protein BANP

2

0

High-throughput

0.580

High

659696

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.580

High

659702

UBL5
Ubiquitin-like protein 5

2

0

High-throughput

0.580

High

659677

HDAC1
Histone deacetylase 1

2

0

Small-scale

0.559

High

659695

KAT2B
Histone acetyltransferase KAT2B

2

0

Small-scale

0.547

High

659675

SRBP2
Sterol regulatory element-binding protein 2

1

1

High-throughput

0.541

High

659678

PWP1
Periodic tryptophan protein 1 homolog

1

1

High-throughput

0.541

High

659661

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.537

High

659692

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

Small-scale

0.537

High

133948

IPO5
Importin-5

1

2

High-throughput

0.536

High

593021

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.536

High

248196

NDK8
Putative nucleoside diphosphate kinase

2

0

High-throughput

0.528

High

549285

SRF
Serum response factor

1

1

Small-scale

0.527

High

659656

MPIP1
M-phase inducer phosphatase 1

1

0

High-throughput

0.518

High

659700

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.518

High

659673

SRSF1
Serine/arginine-rich splicing factor 1

1

0

Small-scale

0.513

High

659705

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.513

High

659709

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.513

High

609902

SPI1
Transcription factor PU.1

1

1

Small-scale

0.501

High

629059

CCNA2
Cyclin-A2

1

1

Small-scale

0.501

High

629502

PO3F2
POU domain, class 3, transcription factor 2

1

1

Small-scale

0.501

High

659664

TAF6
Transcription initiation factor TFIID subunit 6

1

1

Small-scale

0.501

High

659684

TAF12
Transcription initiation factor TFIID subunit 12

1

1

Small-scale

0.501

High

617272

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

4

Small-scale

0.481

High

659699

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

4

Small-scale

0.481

High

421520

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

601562

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.480

High

659658

ELF1
ETS-related transcription factor Elf-1

1

0

Small-scale

0.480

High

659682

TAF11
Transcription initiation factor TFIID subunit 11

1

0

Small-scale

0.480

High

573749

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.479

High

583453

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

5

Small-scale

0.479

High

608956

XBP1
X-box-binding protein 1

1

3

Small-scale

0.479

High

659660

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.479

High

659663

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

Small-scale

0.479

High

659694

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

659704

P63
Tumor protein 63

1

1

Small-scale

0.479

High

659715

ZHX2
Zinc fingers and homeoboxes protein 2

1

1

Small-scale

0.479

High

659659

TGFR2
TGF-beta receptor type-2

1

1

Small-scale

0.470

High

282670

E2F6
Transcription factor E2F6

1

0

Small-scale

0.460

High

224623

ACTN4
Alpha-actinin-4

1

0

Small-scale

0.458

High

295456

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

0

Small-scale

0.458

High

395500

ESR1
Estrogen receptor

1

0

Small-scale

0.458

High

609579

LEG3
Galectin-3

1

0

Small-scale

0.458

High

612872

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

659672

TOP2B
DNA topoisomerase 2-beta

1

0

Small-scale

0.458

High

659707

TLR9
Toll-like receptor 9

1

0

Small-scale

0.458

High

659710

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

659706

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

659708

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

659713

LC7L2
Putative RNA-binding protein Luc7-like 2

4

0

High-throughput

0.364

High

659671

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

3

0

High-throughput

0.347

High

659691

IRGQ
Immunity-related GTPase family Q protein

3

0

High-throughput

0.347

High

659714

TCAF1
TRPM8 channel-associated factor 1

3

0

High-throughput

0.341

High

659657

ILEU
Leukocyte elastase inhibitor

2

0

High-throughput

0.328

High

659662

MAOX
NADP-dependent malic enzyme

2

0

High-throughput

0.318

High

659681

LASP1
LIM and SH3 domain protein 1

2

0

High-throughput

0.318

High

659686

BROX
BRO1 domain-containing protein BROX

1

0

High-throughput

0.279

Low

659689

MINK1
Misshapen-like kinase 1

1

0

High-throughput

0.279

Low

659697

PLPP
Chronophin

1

0

High-throughput

0.279

Low

359792

DYR
Dihydrofolate reductase

1

0

Small-scale

0.249

Low

450215

HYEP
Epoxide hydrolase 1

1

0

Small-scale

0.249

Low

551731

COBA1

1

0

Small-scale

0.249

Low

659667

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

659670

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

659688

GLT16
Polypeptide N-acetylgalactosaminyltransferase 16

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025