Protein: TGM1
Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1)

Gene: TGM1
Organism: Homo sapiens
Interactions: 227
UniProt ID: P22735

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0003810 - protein-glutamine gamma-glutamyltransferase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0010838 - positive regulation of keratinocyte proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

652276

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

3

High-throughput

0.783

High

652352

VSTM4
V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]

2

0

High-throughput

0.742

High

652376

NECT2
Nectin-2

2

0

High-throughput

0.742

High

652381

IGSF8
Immunoglobulin superfamily member 8

2

0

High-throughput

0.742

High

322201

GLSK
Glutaminase kidney isoform, mitochondrial

1

1

High-throughput

0.691

High

652299

CF298
Cilia- and flagella-associated protein 298

3

1

High-throughput

0.667

High

652283

MPI
Mannose-6-phosphate isomerase

3

0

High-throughput

0.638

High

652412

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

391566

FRIH
Ferritin heavy chain

2

2

High-throughput

0.628

High

652318

NONO
Non-POU domain-containing octamer-binding protein

2

1

High-throughput

0.628

High

652393

CDK15
Cyclin-dependent kinase 15

2

1

High-throughput

0.628

High

652429

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.618

High

652436

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

292288

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

3

2

High-throughput

0.609

High

350432

GPAN1
G patch domain and ankyrin repeat-containing protein 1

3

2

High-throughput

0.609

High

652387

MITOK
Mitochondrial potassium channel

3

2

High-throughput

0.609

High

652389

GMCL1
Germ cell-less protein-like 1

3

1

High-throughput

0.609

High

479768

GSTP1
Glutathione S-transferase P

2

1

High-throughput

0.606

High

592619

ITB4
Integrin beta-4

2

3

High-throughput

0.606

High

652278

KRA59
Keratin-associated protein 5-9

2

2

High-throughput

0.606

High

652313

SREC
Scavenger receptor class F member 1

2

2

High-throughput

0.606

High

652332

VASN
Vasorin

2

1

High-throughput

0.606

High

652375

DOCK2
Dedicator of cytokinesis protein 2

2

2

High-throughput

0.606

High

652404

C1QT1
Complement C1q tumor necrosis factor-related protein 1

2

1

High-throughput

0.606

High

652316

TNIP1
TNFAIP3-interacting protein 1

2

2

High-throughput

0.584

High

426048

PPB1
Alkaline phosphatase, placental type

2

0

High-throughput

0.580

High

561106

GILT
Gamma-interferon-inducible lysosomal thiol reductase

2

0

High-throughput

0.580

High

652317

JOS1
Josephin-1

2

0

High-throughput

0.580

High

652326

LCE1E
Late cornified envelope protein 1E

2

0

High-throughput

0.580

High

652327

LCE1B
Late cornified envelope protein 1B

2

0

High-throughput

0.580

High

652328

LCE3A
Late cornified envelope protein 3A

2

0

High-throughput

0.580

High

652329

LCE4A
Late cornified envelope protein 4A

2

0

High-throughput

0.580

High

652362

CNNM3
Metal transporter CNNM3

2

0

High-throughput

0.580

High

652369

TPC14
Trafficking protein particle complex subunit 14

2

0

High-throughput

0.580

High

652397

KR412
Keratin-associated protein 4-12

2

0

High-throughput

0.580

High

652398

ST4A1
Sulfotransferase 4A1

2

0

High-throughput

0.580

High

652445

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

2

0

High-throughput

0.580

High

231104

AIRE
Autoimmune regulator

2

2

High-throughput

0.574

High

652321

ZIC1
Zinc finger protein ZIC 1

2

1

High-throughput

0.574

High

652353

DAA19
Dynein axonemal assembly factor 19

2

1

High-throughput

0.574

High

652423

TB22B
TBC1 domain family member 22B

2

2

High-throughput

0.574

High

652330

MYOME
Myomegalin

2

1

High-throughput

0.558

High

652364

RIN3
Ras and Rab interactor 3

2

0

High-throughput

0.551

High

132566

UPK1A
Uroplakin-1a

1

1

High-throughput

0.536

High

135496

DNM1L
Dynamin-1-like protein

1

3

High-throughput

0.536

High

169440

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.536

High

185160

FANCG
Fanconi anemia group G protein

1

1

High-throughput

0.536

High

216055

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

2

High-throughput

0.536

High

227159

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

2

High-throughput

0.536

High

252010

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.536

High

292555

RENR
Renin receptor

1

2

High-throughput

0.536

High

343557

OXSR1
Serine/threonine-protein kinase OSR1

1

2

High-throughput

0.536

High

358054

ADH1G
Alcohol dehydrogenase 1C

1

1

High-throughput

0.536

High

552130

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.536

High

602735

AATC
Aspartate aminotransferase, cytoplasmic

1

2

High-throughput

0.536

High

618979

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

High-throughput

0.536

High

639188

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

High-throughput

0.536

High

652280

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

2

High-throughput

0.536

High

652281

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

652282

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.536

High

652289

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.536

High

652291

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.536

High

652293

ASCL1
Achaete-scute homolog 1

1

1

High-throughput

0.536

High

652297

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

652303

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

2

High-throughput

0.536

High

652304

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.536

High

652305

FAK1
Focal adhesion kinase 1

1

5

High-throughput

0.536

High

652320

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

652323

QRIC1
Transcriptional regulator QRICH1

1

1

High-throughput

0.536

High

652334

EDC4
Enhancer of mRNA-decapping protein 4

1

1

High-throughput

0.536

High

652338

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.536

High

652344

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.536

High

652348

AROS
Active regulator of SIRT1

1

1

High-throughput

0.536

High

652350

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

1

2

High-throughput

0.536

High

652359

PLD5
Inactive phospholipase D5

1

1

High-throughput

0.536

High

652361

FNDC5
Fibronectin type III domain-containing protein 5

1

4

High-throughput

0.536

High

652365

MYBPP
MYCBP-associated protein

1

1

High-throughput

0.536

High

652366

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

1

High-throughput

0.536

High

652371

THAP4
Peroxynitrite isomerase THAP4

1

4

High-throughput

0.536

High

652372

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

1

1

High-throughput

0.536

High

652377

STAM1
Signal transducing adapter molecule 1

1

2

High-throughput

0.536

High

652378

CBP
CREB-binding protein

1

2

High-throughput

0.536

High

652380

PIGT
GPI-anchor transamidase component PIGT

1

1

High-throughput

0.536

High

652382

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.536

High

652388

MTNB
Methylthioribulose-1-phosphate dehydratase

1

1

High-throughput

0.536

High

652396

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.536

High

652405

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.536

High

652415

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

1

High-throughput

0.536

High

652420

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

652424

KLH11
Kelch-like protein 11

1

1

High-throughput

0.536

High

652435

DBNL
Drebrin-like protein

1

2

High-throughput

0.536

High

652438

DYN3
Dynamin-3

1

3

High-throughput

0.536

High

652442

TLN1
Talin-1

1

2

High-throughput

0.536

High

652444

RN115
E3 ubiquitin-protein ligase RNF115

1

1

High-throughput

0.536

High

652446

S23IP
SEC23-interacting protein

1

2

High-throughput

0.536

High

280504

PR40A
Pre-mRNA-processing factor 40 homolog A

1

5

High-throughput

0.515

High

561895

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

652296

CASP6
Caspase-6

1

2

High-throughput

0.515

High

652441

SHLB1
Endophilin-B1

1

2

High-throughput

0.515

High

222352

TSN6
Tetraspanin-6

1

0

High-throughput

0.513

High

229214

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.513

High

254809

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.513

High

325282

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.513

High

352681

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

652286

FEN1
Flap endonuclease 1

1

0

High-throughput

0.513

High

652290

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

652294

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

0

High-throughput

0.513

High

652295

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

652319

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

652351

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.513

High

652356

D106A
Beta-defensin 106

1

0

High-throughput

0.513

High

652363

NFAM1
NFAT activation molecule 1

1

0

High-throughput

0.513

High

652370

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

652373

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.513

High

652385

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.513

High

652386

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.513

High

652390

SNX27
Sorting nexin-27

1

0

High-throughput

0.513

High

652392

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.513

High

652395

FCRL5
Fc receptor-like protein 5

1

0

High-throughput

0.513

High

652401

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.513

High

652402

THUM3
tRNA

1

0

High-throughput

0.513

High

652403

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

652411

NELFA
Negative elongation factor A

1

0

High-throughput

0.513

High

652416

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.513

High

652421

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.513

High

652428

UBIP1
Upstream-binding protein 1

1

0

High-throughput

0.513

High

213393

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

1

High-throughput

0.504

High

652285

SYUA
Alpha-synuclein

1

1

Small-scale

0.501

High

282669

E2F6
Transcription factor E2F6

1

1

High-throughput

0.489

High

335302

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

1

High-throughput

0.489

High

420242

IFNA4
Interferon alpha-4

1

1

High-throughput

0.489

High

622749

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

2

High-throughput

0.489

High

651059

RFX1
MHC class II regulatory factor RFX1

1

2

High-throughput

0.489

High

652277

CCNC
Cyclin-C

1

1

High-throughput

0.489

High

652307

FGL1
Fibrinogen-like protein 1

1

2

High-throughput

0.489

High

652311

ZN154
Zinc finger protein 154

1

2

High-throughput

0.489

High

652324

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

652335

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.489

High

652337

AMTN
Amelotin

1

1

High-throughput

0.489

High

652340

APTX
Aprataxin

1

1

High-throughput

0.489

High

652341

PBIR2
PABIR family member 2

1

1

High-throughput

0.489

High

652342

ZN550
Zinc finger protein 550

1

1

High-throughput

0.489

High

652346

MOGT3
2-acylglycerol O-acyltransferase 3

1

1

High-throughput

0.489

High

652347

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.489

High

652354

RAVR1
Ribonucleoprotein PTB-binding 1

1

1

High-throughput

0.489

High

652367

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.489

High

652384

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

652399

SH23A
SH2 domain-containing protein 3A

1

4

High-throughput

0.489

High

652400

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

652406

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.489

High

652408

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

2

High-throughput

0.489

High

652419

TSSP
Thymus-specific serine protease

1

2

High-throughput

0.489

High

652422

RBM12
RNA-binding protein 12

1

3

High-throughput

0.489

High

652430

THA10
THAP domain-containing protein 10

1

1

High-throughput

0.489

High

652434

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

652437

SATB2
DNA-binding protein SATB2

1

1

High-throughput

0.489

High

652440

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

334273

TACC2
Transforming acidic coiled-coil-containing protein 2

1

1

High-throughput

0.481

High

141323

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

302376

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.479

High

375175

RASK
GTPase KRas

1

1

High-throughput

0.479

High

411359

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

413194

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

536508

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

563203

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

652284

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.479

High

652287

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

652292

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

652301

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

652309

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

652314

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

652336

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

652368

TP4AP
Short transient receptor potential channel 4-associated protein

1

1

High-throughput

0.479

High

652374

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

652383

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

Small-scale

0.479

High

652407

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

652418

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

652432

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

652443

LOXL2
Lysyl oxidase homolog 2

1

4

High-throughput

0.479

High

74233

B2RWP4
TACC2 protein

1

1

High-throughput

0.470

High

652410

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.460

High

557867

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

652288

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

652300

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.445

High

652331

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

652409

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.445

High

371174

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

405793

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

652312

DX39B
Spliceosome RNA helicase DDX39B

1

3

High-throughput

0.437

High

652325

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.437

High

652355

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.437

High

652357

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

652379

RBP56
TATA-binding protein-associated factor 2N

1

6

High-throughput

0.437

High

652427

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.437

High

652360

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

652339

DPPA4
Developmental pluripotency-associated protein 4

3

0

High-throughput

0.347

High

376976

ANF
Natriuretic peptides A

2

0

High-throughput

0.328

High

652343

SO6A1
Solute carrier organic anion transporter family member 6A1

2

0

High-throughput

0.328

High

652333

TECT3
Tectonic-3

2

0

High-throughput

0.318

High

652279

ACADL
Long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.316

High

652345

MYPOP
Myb-related transcription factor, partner of profilin

2

0

High-throughput

0.316

High

652433

CRCT1
Cysteine-rich C-terminal protein 1

2

0

High-throughput

0.316

High

135777

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

231202

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.279

Low

331630

MBD4
Methyl-CpG-binding domain protein 4

1

0

High-throughput

0.279

Low

559666

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.279

Low

576164

PO2F1
POU domain, class 2, transcription factor 1

1

0

High-throughput

0.279

Low

652298

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

652302

TBPL1
TATA box-binding protein-like 1

1

0

High-throughput

0.279

Low

652306

GABPA
GA-binding protein alpha chain

1

0

High-throughput

0.279

Low

652308

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

0

High-throughput

0.279

Low

652310

CSTF3
Cleavage stimulation factor subunit 3

1

0

High-throughput

0.279

Low

652315

FASTK
Fas-activated serine/threonine kinase

1

0

High-throughput

0.279

Low

652322

QSER1
Glutamine and serine-rich protein 1

1

0

High-throughput

0.279

Low

652349

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

0

High-throughput

0.279

Low

652358

FNBP4
Formin-binding protein 4

1

0

High-throughput

0.279

Low

652391

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.279

Low

652394

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

652413

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

652414

HES4
Transcription factor HES-4

1

0

High-throughput

0.279

Low

652417

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

0

High-throughput

0.279

Low

652425

RFOX1
RNA binding protein fox-1 homolog 1

1

0

High-throughput

0.279

Low

652426

GPT2L
G patch domain-containing protein 2-like

1

0

High-throughput

0.279

Low

652431

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

652439

SCML2
Sex comb on midleg-like protein 2

1

0

High-throughput

0.279

Low

505281

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025