Protein: DPH6
Diphthine--ammonia ligase (EC 6.3.1.14) (ATP-binding domain-containing protein 4) (Diphthamide synthase) (Diphthamide synthetase) (Protein DPH6 homolog)

Gene: DPH6
Organism: Homo sapiens
Interactions: 30
UniProt ID: Q7L8W6

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0017178 - diphthine-ammonia ligase activity
GO:0017183 - protein histidyl modification to diphthamide

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1032602

AT2B2
Plasma membrane calcium-transporting ATPase 2

3

0

High-throughput

0.638

High

845518

PI2R
Prostacyclin receptor

2

1

High-throughput

0.628

High

720619

GRPR
Gastrin-releasing peptide receptor

2

1

High-throughput

0.574

High

424217

S10A8
Protein S100-A8

1

1

High-throughput

0.536

High

445210

S10A6
Protein S100-A6

1

1

High-throughput

0.536

High

1128041

DHX8
ATP-dependent RNA helicase DHX8

1

0

High-throughput

0.513

High

638460

FPR1
fMet-Leu-Phe receptor

1

4

High-throughput

0.489

High

640407

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

3

High-throughput

0.489

High

1273074

C5AR2
C5a anaphylatoxin chemotactic receptor 2

1

5

High-throughput

0.489

High

722875

SSR2
Somatostatin receptor type 2

1

2

High-throughput

0.445

High

410918

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

High-throughput

0.426

High

1273076

DAAM1
Disheveled-associated activator of morphogenesis 1

1

0

High-throughput

0.426

High

886083

CXCR3
C-X-C chemokine receptor type 3

1

2

High-throughput

0.407

High

1101551

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.407

High

1216322

MFS4B
Sodium-dependent glucose transporter 1

3

0

High-throughput

0.347

High

273770

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

2

0

High-throughput

0.328

High

926796

VMAT1
Chromaffin granule amine transporter

2

0

High-throughput

0.328

High

754056

CD80
T-lymphocyte activation antigen CD80

2

0

High-throughput

0.313

High

1273078

NPTN
Neuroplastin

2

0

High-throughput

0.313

High

1086618

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.282

High

1248476

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

0

High-throughput

0.279

Low

1273072

MORC1
MORC family CW-type zinc finger protein 1

1

0

High-throughput

0.279

Low

1273075

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.279

Low

1273073

CT55
Cancer/testis antigen 55

1

0

High-throughput

0.269

Low

1100052

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

914437

EFNB2
Ephrin-B2

1

0

High-throughput

0.232

Low

1149587

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.232

Low

1212260

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.232

Low

1273071

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.232

Low

1273077

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025