Protein: PI2R
Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)

Gene: PI2R, PTGIR
Organism: Homo sapiens
Interactions: 71
UniProt ID: P43119

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response
GO:0007187 - G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

845506

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

4

20

Small-scale

0.878

High

640495

TA2R
Thromboxane A2 receptor

3

17

Small-scale

0.840

High

845547

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

0

High-throughput

0.770

High

845499

PI2R
Prostacyclin receptor

2

16

Small-scale

0.768

High

603199

KPCA
Protein kinase C alpha type

1

3

Small-scale

0.647

High

320436

TM63A
Mechanosensitive cation channel TMEM63A

2

1

High-throughput

0.628

High

336530

PIGN
GPI ethanolamine phosphate transferase 1

2

2

High-throughput

0.628

High

419968

B3A2
Anion exchange protein 2

2

3

High-throughput

0.628

High

624608

SL9A1
Sodium/hydrogen exchanger 1

2

2

High-throughput

0.628

High

665073

COT2
COUP transcription factor 2

2

2

High-throughput

0.628

High

732802

GLPK
Glycerol kinase

2

1

High-throughput

0.628

High

783030

CXG1
Gap junction gamma-1 protein

2

7

High-throughput

0.628

High

845503

S12A2
Solute carrier family 12 member 2

2

5

High-throughput

0.628

High

845504

MFAP3
Microfibril-associated glycoprotein 3

2

1

High-throughput

0.628

High

845507

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

12

High-throughput

0.628

High

845508

PKD2
Polycystin-2

2

1

High-throughput

0.628

High

845513

TM63B
Mechanosensitive cation channel TMEM63B

2

1

High-throughput

0.628

High

845515

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

7

High-throughput

0.628

High

845517

ANO5
Anoctamin-5

2

2

High-throughput

0.628

High

845518

DPH6
Diphthine--ammonia ligase

2

1

High-throughput

0.628

High

845522

DAAF5
Dynein axonemal assembly factor 5

2

2

High-throughput

0.628

High

845524

AT11C
Phospholipid-transporting ATPase IG

2

4

High-throughput

0.628

High

845527

EDA
Ectodysplasin-A

2

1

High-throughput

0.628

High

845534

S29A1
Equilibrative nucleoside transporter 1

2

1

High-throughput

0.628

High

845538

S12A9
Solute carrier family 12 member 9

2

8

High-throughput

0.628

High

845540

TTYH3
Protein tweety homolog 3

2

2

High-throughput

0.628

High

845543

PCD10
Protocadherin-10

2

2

High-throughput

0.628

High

845544

S53A1
Solute carrier family 53 member 1

2

1

High-throughput

0.628

High

845548

S12A6
Solute carrier family 12 member 6

2

8

High-throughput

0.628

High

845551

S12A7
Solute carrier family 12 member 7

2

8

High-throughput

0.628

High

845552

ZNT1
Proton-coupled zinc antiporter SLC30A1

2

3

High-throughput

0.628

High

845505

RB11A
Ras-related protein Rab-11A

2

1

Small-scale

0.619

High

845501

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

Small-scale

0.618

High

845545

GHRL
Appetite-regulating hormone

1

2

Small-scale

0.618

High

845500

SC6A8
Sodium- and chloride-dependent creatine transporter 1

2

0

High-throughput

0.602

High

845509

FZD2
Frizzled-2

2

0

High-throughput

0.602

High

845520

T179B
Transmembrane protein 179B

2

0

High-throughput

0.602

High

845523

S15A4
Solute carrier family 15 member 4

2

0

High-throughput

0.602

High

845541

XKR8
XK-related protein 8

2

0

High-throughput

0.602

High

399667

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

2

2

High-throughput

0.574

High

845511

MTX3
Metaxin-3

2

3

High-throughput

0.574

High

845516

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

2

2

High-throughput

0.574

High

845525

MFSD8
Major facilitator superfamily domain-containing protein 8

2

3

High-throughput

0.574

High

845528

GLMN
Glomulin

2

2

High-throughput

0.574

High

845542

DJC18
DnaJ homolog subfamily C member 18

2

1

High-throughput

0.574

High

845512

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

20

Small-scale

0.552

High

845521

NHRF4
Na(+)/H(+) exchange regulatory cofactor NHE-RF4

1

20

Small-scale

0.552

High

560957

GP1BB
Platelet glycoprotein Ib beta chain

1

2

High-throughput

0.536

High

845502

CTR2
Cationic amino acid transporter 2

1

5

High-throughput

0.536

High

845532

VMP1
Vacuole membrane protein 1

1

1

High-throughput

0.536

High

845535

GCP2
Gamma-tubulin complex component 2

1

7

High-throughput

0.536

High

845536

YIPF4
Protein YIPF4

1

3

High-throughput

0.536

High

845539

OSBL8
Oxysterol-binding protein-related protein 8

1

2

High-throughput

0.536

High

845550

FLVC1
Choline/ethanolamine transporter FLVCR1

1

1

High-throughput

0.536

High

231379

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

Small-scale

0.529

High

212557

GPAA1
GPI-anchor transamidase component GPAA1

1

0

High-throughput

0.513

High

536682

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

845514

STEA3
Metalloreductase STEAP3

1

0

High-throughput

0.513

High

845529

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

High-throughput

0.513

High

845531

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.513

High

845549

SNX14
Sorting nexin-14

1

0

High-throughput

0.513

High

845530

S2546
Mitochondrial outer membrane protein SLC25A46

1

3

High-throughput

0.489

High

845533

ARL5B
ADP-ribosylation factor-like protein 5B

1

5

High-throughput

0.489

High

845537

NFIP1
NEDD4 family-interacting protein 1

1

4

High-throughput

0.489

High

631104

RAB5A
Ras-related protein Rab-5A

1

3

Small-scale

0.479

High

845526

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.439

High

698462

CALX
Calnexin

1

5

Small-scale

0.437

High

845510

CEGT
Ceramide glucosyltransferase

2

0

High-throughput

0.328

High

845519

ATG9A
Autophagy-related protein 9A

2

0

High-throughput

0.328

High

845546

FA8A1
Protein FAM8A1

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025