Protein: PELI2
E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2)

Gene: PELI2
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q9HAT8

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0001934 - positive regulation of protein phosphorylation
GO:0005829 - cytosol
GO:0008592 - regulation of Toll signaling pathway
GO:0034450 - ubiquitin-ubiquitin ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

905683

IRAK1
Interleukin-1 receptor-associated kinase 1

7

10

Small-scale

0.750

High

159861

DVL2
Segment polarity protein dishevelled homolog DVL-2

3

1

Small-scale

0.661

High

1437657

IRAK4
Interleukin-1 receptor-associated kinase 4

2

2

Small-scale

0.653

High

1437660

TRAF6
TNF receptor-associated factor 6

3

3

Small-scale

0.650

High

214042

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

5

Small-scale

0.640

High

1049003

REL
Proto-oncogene c-Rel

2

1

High-throughput

0.606

High

831454

CCNF
Cyclin-F

2

0

Small-scale

0.593

High

1246163

TRAF7
E3 ubiquitin-protein ligase TRAF7

2

0

Small-scale

0.593

High

1350567

NEK9
Serine/threonine-protein kinase Nek9

2

0

Small-scale

0.593

High

1437662

ROBO1
Roundabout homolog 1

2

0

Small-scale

0.593

High

789225

NUP62
Nuclear pore glycoprotein p62

2

0

High-throughput

0.580

High

1036863

SP4
Transcription factor Sp4

2

0

High-throughput

0.580

High

1089129

HYAL2
Hyaluronidase-2

2

0

High-throughput

0.580

High

1093431

TRI32
E3 ubiquitin-protein ligase TRIM32

2

0

High-throughput

0.580

High

1144880

RABE1
Rab GTPase-binding effector protein 1

2

0

High-throughput

0.580

High

1437654

LZTL1
Leucine zipper transcription factor-like protein 1

2

0

High-throughput

0.580

High

1254003

CL17A
C-type lectin domain family 17, member A

2

1

High-throughput

0.553

High

1432525

P63
Tumor protein 63

2

3

High-throughput

0.553

High

772522

IRS1
Insulin receptor substrate 1

1

1

Small-scale

0.552

High

1402590

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.550

High

1437655

UBQL4
Ubiquilin-4

1

0

High-throughput

0.518

High

210208

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

11

Small-scale

0.479

High

879477

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

Small-scale

0.479

High

642587

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.460

High

1107619

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.460

High

1217716

RN220
E3 ubiquitin-protein ligase RNF220

1

0

Small-scale

0.460

High

1228211

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

0

High-throughput

0.460

High

1437653

MYO10
Unconventional myosin-X

1

0

Small-scale

0.460

High

280430

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

1

High-throughput

0.439

High

1406590

CTIP
DNA endonuclease RBBP8

1

1

Small-scale

0.439

High

869244

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

Small-scale

0.437

High

414649

P53
Cellular tumor antigen p53

1

3

Small-scale

0.408

High

766123

PCGF2
Polycomb group RING finger protein 2

2

0

High-throughput

0.316

High

893740

MEOX1
Homeobox protein MOX-1

2

0

High-throughput

0.316

High

1401199

OR7D2
Olfactory receptor 7D2

2

0

High-throughput

0.316

High

1403789

RMD3
Regulator of microtubule dynamics protein 3

2

0

High-throughput

0.316

High

1407092

MDFI
MyoD family inhibitor

2

0

High-throughput

0.316

High

1412311

TMM79
Transmembrane protein 79

2

0

High-throughput

0.316

High

1437658

SEPT3
Neuronal-specific septin-3

2

0

High-throughput

0.316

High

299792

MPDZ
Multiple PDZ domain protein

1

0

Small-scale

0.251

Low

321938

FRYL
Protein furry homolog-like

1

0

High-throughput

0.251

Low

389518

FINC
Fibronectin

1

0

High-throughput

0.251

Low

965893

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

0

High-throughput

0.251

Low

1393122

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.251

Low

1413131

THAP7
THAP domain-containing protein 7

1

0

High-throughput

0.251

Low

1437656

LTBP3
Latent-transforming growth factor beta-binding protein 3

1

0

High-throughput

0.251

Low

1437659

C170B
Centrosomal protein of 170 kDa protein B

1

0

Small-scale

0.251

Low

1437661

LAMC3
Laminin subunit gamma-3

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025