Protein: LCD1
DNA damage checkpoint protein LCD1 (DNA damage checkpoint protein 2) (Lethal, checkpoint-defective, DNA damage-sensitive protein 1)

Gene: LCD1
Organism: Saccharomyces cerevisiae S288C
Interactions: 41
UniProt ID: Q04377

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000228 - nuclear chromosome
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

793453

ATR
Serine/threonine-protein kinase MEC1

18

1

Small-scale

0.990

High

1046548

LCD1
DNA damage checkpoint protein LCD1

2

0

Small-scale

0.758

High

647832

RFA1
Replication factor A protein 1

6

0

Small-scale

0.705

High

805218

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

1

Small-scale

0.647

High

806115

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

3

0

High-throughput

0.634

High

722241

XPO1
Exportin-1

2

0

Small-scale

0.609

High

864250

DPB11
DNA replication regulator DPB11

2

0

Small-scale

0.599

High

1044184

MSH6
DNA mismatch repair protein MSH6

2

0

High-throughput

0.595

High

688766

RFA2
Replication factor A protein 2

2

0

High-throughput

0.576

High

688821

RFA3
Replication factor A protein 3

2

0

Small-scale

0.569

High

358422

ADH2
Alcohol dehydrogenase 2

1

1

High-throughput

0.536

High

793563

ADH5
Alcohol dehydrogenase 5

1

1

High-throughput

0.536

High

382328

H4
Histone H4

1

0

High-throughput

0.513

High

673127

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.513

High

865943

YJ66
Uncharacterized oxidoreductase YJR096W

1

0

High-throughput

0.493

High

531399

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

643664

SNF2
Transcription regulatory protein SNF2

1

0

Small-scale

0.458

High

647215

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

781963

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.458

High

815567

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

Small-scale

0.458

High

826813

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

864822

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

916882

RTF1
RNA polymerase-associated protein RTF1

1

0

Small-scale

0.458

High

917321

INO80
Chromatin-remodeling ATPase INO80

1

0

Small-scale

0.458

High

925243

ARP5
Actin-related protein 5

1

0

Small-scale

0.458

High

1043917

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.458

High

1046549

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

1046551

HFI1
SAGA complex subunit HFI1

1

0

Small-scale

0.458

High

1046550

RBX1
RING-box protein HRT1

1

0

High-throughput

0.438

High

510796

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.426

High

742350

HSP7F
Heat shock protein homolog SSE1

1

0

High-throughput

0.426

High

826152

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.282

High

439165

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.279

Low

598339

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.279

Low

367116

ATPB
ATP synthase subunit beta, mitochondrial

1

0

High-throughput

0.261

Low

405140

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

673530

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low

677723

VAC17
vacuole-related protein 17

1

0

High-throughput

0.249

Low

705221

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

917368

YGO0
Uncharacterized membrane protein YGL140C

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025