Protein: MDHC
Malate dehydrogenase, cytoplasmic (EC 1.1.1.37)

Gene: MDHC, MDH2
Organism: Saccharomyces cerevisiae S288C
Interactions: 67
UniProt ID: P22133

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006094 - gluconeogenesis
GO:0006099 - tricarboxylic acid cycle
GO:0006108 - malate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

644606

MDHC
Malate dehydrogenase, cytoplasmic

3

15

Small-scale

0.833

High

644622

GID4
GID complex substrate-recognition subunit 4

3

1

Small-scale

0.662

High

644615

MDHP
Malate dehydrogenase, peroxisomal

1

15

Small-scale

0.621

High

604901

MDHM
Malate dehydrogenase, mitochondrial

1

14

Small-scale

0.618

High

644611

GID7
GID complex subunit 7

2

1

Small-scale

0.595

High

644649

GET3
ATPase GET3

2

0

High-throughput

0.594

High

543823

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.584

High

392232

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.571

High

523065

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.552

High

644637

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.536

High

644631

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.513

High

644632

YIK8
Putative zinc metalloproteinase YIL108W

1

0

High-throughput

0.513

High

644650

RPN5
26S proteasome regulatory subunit RPN5

1

0

High-throughput

0.513

High

644634

GST1
Glutathione S-transferase 1

1

3

High-throughput

0.508

High

644638

KPYK2
Pyruvate kinase 2

1

1

High-throughput

0.508

High

405028

LEU3
3-isopropylmalate dehydrogenase

1

6

High-throughput

0.500

High

486030

TBA1
Tubulin alpha-1 chain

1

3

High-throughput

0.500

High

578853

HSC82
ATP-dependent molecular chaperone HSC82

1

9

High-throughput

0.500

High

597037

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.500

High

626586

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.500

High

644607

CLH
Clathrin heavy chain

1

2

High-throughput

0.500

High

644612

CDC48
Cell division control protein 48

1

8

High-throughput

0.500

High

644624

YHI0
Putative proline--tRNA ligase YHR020W

1

2

High-throughput

0.500

High

644628

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.500

High

610090

PDI
Protein disulfide-isomerase

1

6

High-throughput

0.489

High

479667

F16P
Fructose-1,6-bisphosphatase

1

0

Small-scale

0.480

High

420879

PMA1
Plasma membrane ATPase 1

1

0

High-throughput

0.479

High

452476

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.479

High

531242

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

598808

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

0

High-throughput

0.479

High

644610

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.479

High

644614

URA7
CTP synthase 1

1

0

High-throughput

0.479

High

475157

CISY2
Citrate synthase, peroxisomal

1

7

High-throughput

0.479

High

644608

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.479

High

644617

TOR1
Serine/threonine-protein kinase TOR1

1

2

Small-scale

0.479

High

644620

FAT2
Oxalate--CoA ligase

1

2

High-throughput

0.479

High

644621

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.479

High

644625

KOG1
Target of rapamycin complex 1 subunit KOG1

1

4

Small-scale

0.479

High

644626

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

1

High-throughput

0.479

High

644635

LST8
Target of rapamycin complex subunit LST8

1

1

Small-scale

0.479

High

644639

STR3
Cystathionine beta-lyase

1

1

High-throughput

0.479

High

644642

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

644647

DCI1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase

1

6

High-throughput

0.479

High

644633

MGA2
Protein MGA2

1

1

High-throughput

0.464

High

644618

PMU1
Probable phosphoglycerate mutase PMU1

1

0

High-throughput

0.458

High

644619

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.458

High

644636

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.458

High

644641

PEX8
Peroxisomal biogenesis factor 8

1

0

High-throughput

0.458

High

644640

GID10
GID complex substrate-recognition subunit 10

1

1

Small-scale

0.457

High

456331

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.457

High

644644

ACT
Actin

1

2

High-throughput

0.457

High

509397

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

12

High-throughput

0.445

High

510196

HSP77
Import motor subunit, mitochondrial

1

10

High-throughput

0.445

High

644629

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

644616

CACP
Carnitine O-acetyltransferase, mitochondrial

1

2

High-throughput

0.437

High

644623

HXT5
Probable glucose transporter HXT5

1

1

High-throughput

0.437

High

644627

LCF2
Long-chain-fatty-acid--CoA ligase 2

1

1

High-throughput

0.437

High

644645

FOX2
Peroxisomal hydratase-dehydrogenase-epimerase

1

3

High-throughput

0.437

High

644646

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

644609

EXG1
Glucan 1,3-beta-glucosidase I/II

1

0

High-throughput

0.279

Low

644630

RFC2
Replication factor C subunit 2

1

0

High-throughput

0.279

Low

575380

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.261

Low

644613

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.249

Low

644643

YG37
Uncharacterized protein YGR127W

1

0

High-throughput

0.249

Low

644648

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

Small-scale

0.249

Low

644651

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025