Protein: PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2 (PDEase 2) (EC 3.1.4.53) (High-affinity cAMP phosphodiesterase)

Gene: PDE2
Organism: Saccharomyces cerevisiae S288C
Interactions: 86
UniProt ID: P06776

Gene Ontology (top 5):
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0019933 - cAMP-mediated signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

448266

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

7

High-throughput

0.618

High

448317

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.518

High

448318

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

1

High-throughput

0.515

High

448319

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.515

High

448301

LHS1
Heat shock protein 70 homolog LHS1

1

2

High-throughput

0.494

High

380917

H2B1
Histone H2B.1

1

2

High-throughput

0.479

High

381358

H2B2
Histone H2B.2

1

2

High-throughput

0.479

High

419320

H2A1
Histone H2A.1

1

1

High-throughput

0.479

High

419546

H2A2
Histone H2A.2

1

1

High-throughput

0.479

High

448272

NHP6A
Non-histone chromosomal protein 6A

1

2

High-throughput

0.479

High

448273

NHP6B
Non-histone chromosomal protein 6B

1

2

High-throughput

0.479

High

448282

RCC1
Guanine nucleotide exchange factor SRM1

1

2

High-throughput

0.479

High

448308

RCK2
Serine/threonine-protein kinase RCK2

1

6

High-throughput

0.479

High

448313

ATAD2
ATPase histone chaperone YTA7

1

1

High-throughput

0.479

High

448330

ABF2
ARS-binding factor 2, mitochondrial

1

3

High-throughput

0.479

High

448333

HMO1
High mobility group protein 1

1

3

High-throughput

0.479

High

448343

H2AZ
Histone H2A.Z

1

2

High-throughput

0.479

High

448292

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.470

High

381787

H4
Histone H4

1

0

High-throughput

0.458

High

448267

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.458

High

448268

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

448274

RAP1
DNA-binding protein RAP1

1

0

High-throughput

0.458

High

448275

TBP
TATA-box-binding protein

1

0

High-throughput

0.458

High

448276

ABF1
ARS-binding factor 1

1

0

High-throughput

0.458

High

448278

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.458

High

448279

GLN3
Nitrogen regulatory protein GLN3

1

0

High-throughput

0.458

High

448280

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

448281

ACE2
Metallothionein expression activator

1

0

High-throughput

0.458

High

448283

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

448284

RFA1
Replication factor A protein 1

1

0

High-throughput

0.458

High

448286

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

448287

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

High-throughput

0.458

High

448288

MIG1
Regulatory protein MIG1

1

0

High-throughput

0.458

High

448289

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.458

High

448291

IMB3
Importin subunit beta-3

1

0

High-throughput

0.458

High

448294

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.458

High

448296

IES6
Chromatin-remodeling complex subunit IES6

1

0

High-throughput

0.458

High

448297

T2AG
Transcription initiation factor IIA subunit 2

1

0

High-throughput

0.458

High

448298

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.458

High

448299

MSN2
Zinc finger protein MSN2

1

0

High-throughput

0.458

High

448300

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

448302

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.458

High

448303

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.458

High

448304

NOP4
Nucleolar protein 4

1

0

High-throughput

0.458

High

448306

SWC5
SWR1-complex protein 5

1

0

High-throughput

0.458

High

448310

NOP16
Nucleolar protein 16

1

0

High-throughput

0.458

High

448312

IES2
Ino eighty subunit 2

1

0

High-throughput

0.458

High

448314

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

448316

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

448320

RPA14
DNA-directed RNA polymerase I subunit RPA14

1

0

High-throughput

0.458

High

448321

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.458

High

448322

H1
Histone H1

1

0

High-throughput

0.458

High

448323

CRZ1
Transcriptional regulator CRZ1

1

0

High-throughput

0.458

High

448324

SUB1
RNA polymerase II transcriptional coactivator SUB1

1

0

High-throughput

0.458

High

448325

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.458

High

448326

H3
Histone H3

1

0

High-throughput

0.458

High

448327

DID2
Vacuolar protein-sorting-associated protein 46

1

0

High-throughput

0.458

High

448328

HPC2
Histone promoter control protein 2

1

0

High-throughput

0.458

High

448329

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.458

High

448331

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.458

High

448335

DPB4
DNA polymerase epsilon subunit D

1

0

High-throughput

0.458

High

448336

ECM22
Sterol regulatory element-binding protein ECM22

1

0

High-throughput

0.458

High

448337

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

448338

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.458

High

448342

IES4
Ino eighty subunit 4

1

0

High-throughput

0.458

High

448344

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.458

High

448269

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

448270

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

448271

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

448311

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

448332

NSE5
Non-structural maintenance of chromosome element 5

1

0

High-throughput

0.438

High

448277

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.249

Low

448285

RL24B
Large ribosomal subunit protein eL24B

1

0

High-throughput

0.249

Low

448290

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.249

Low

448293

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

0

High-throughput

0.249

Low

448295

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

448305

LDB7
Chromatin structure-remodeling complex protein RSC14

1

0

High-throughput

0.249

Low

448307

RGD1
RHO GTPase-activating protein RGD1

1

0

High-throughput

0.249

Low

448309

CIC1
Proteasome-interacting protein CIC1

1

0

High-throughput

0.249

Low

448315

NET1
Nucleolar protein NET1

1

0

High-throughput

0.249

Low

448334

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.249

Low

448339

NOP6
Nucleolar protein 6

1

0

High-throughput

0.249

Low

448340

NOP12
Nucleolar protein 12

1

0

High-throughput

0.249

Low

448341

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.249

Low

448345

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025