Protein: DHOM
Homoserine dehydrogenase (HDH) (HSD) (EC 1.1.1.3)

Gene: DHOM, HOM6
Organism: Saccharomyces cerevisiae S288C
Interactions: 49
UniProt ID: P31116

Gene Ontology (top 5):
GO:0004412 - homoserine dehydrogenase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0009067 - aspartate family amino acid biosynthetic process
GO:0009086 - methionine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

724325

DHOM
Homoserine dehydrogenase

2

1

Small-scale

0.737

High

578999

HSC82
ATP-dependent molecular chaperone HSC82

3

2

High-throughput

0.643

High

544093

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

724337

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.513

High

670433

SIS1
Protein SIS1

1

0

High-throughput

0.493

High

622893

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.479

High

624978

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.479

High

724334

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.479

High

724346

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.479

High

358982

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.479

High

367713

ENO1
Enolase 1

1

1

High-throughput

0.479

High

392375

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.479

High

365580

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

368420

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

416395

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

439280

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

572535

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

575905

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.458

High

706429

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

724326

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

724329

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

724332

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

724335

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

724339

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

724340

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

724342

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

724344

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

724345

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

724348

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

724349

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

724338

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

367923

ENO2
Enolase 2

1

1

High-throughput

0.437

High

724333

CH10
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.437

High

724350

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

394326

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

526125

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

597064

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

724341

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.251

Low

368619

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.249

Low

555030

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.249

Low

724327

YPT7
Ypt/Rab-type GTPase YPT7

1

0

Small-scale

0.249

Low

724328

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

724330

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.249

Low

724336

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

724343

MTM1
Mitochondrial carrier protein MTM1

1

0

High-throughput

0.249

Low

724347

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

603427

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.232

Low

724331

CTM1
Cytochrome c lysine N-methyltransferase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025