Protein: MDS3
Negative regulator of sporulation MDS3 (MCK1 dosage suppressor 3)

Gene: MDS3
Organism: Saccharomyces cerevisiae S288C
Interactions: 53
UniProt ID: P53094

Gene Ontology (top 5):
GO:0004601 - peroxidase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0007124 - pseudohyphal growth

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416899

CDC25
Cell division control protein 25

4

1

High-throughput

0.700

High

709429

HRR25
Casein kinase I homolog HRR25

3

1

Small-scale

0.667

High

633492

PP11
Serine/threonine-protein phosphatase PP1-1

3

0

Small-scale

0.634

High

798042

YB75
Uncharacterized protein YBR225W

4

1

High-throughput

0.623

High

828494

SA185
SIT4-associating protein SAP185

2

1

High-throughput

0.601

High

734702

IMB3
Importin subunit beta-3

2

0

High-throughput

0.595

High

667143

CG23
G2/mitotic-specific cyclin-3

2

0

Small-scale

0.585

High

441385

KAPB
cAMP-dependent protein kinase type 2

1

1

High-throughput

0.536

High

642426

MCK1
Protein kinase MCK1

1

2

High-throughput

0.536

High

752521

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.536

High

867851

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

1

High-throughput

0.536

High

722107

XPO1
Exportin-1

1

0

High-throughput

0.513

High

779006

MYO3
Myosin-3

1

1

High-throughput

0.501

High

917096

MYO5
Myosin-5

1

1

High-throughput

0.501

High

820481

MMF1
Protein MMF1, mitochondrial

1

0

High-throughput

0.493

High

917092

FPK1
Flippase kinase 1

1

0

Small-scale

0.480

High

917095

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

479690

F16P
Fructose-1,6-bisphosphatase

1

0

Small-scale

0.458

High

743405

TOR2
Serine/threonine-protein kinase TOR2

1

0

High-throughput

0.458

High

917098

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

917099

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

917101

RMD5
E3 ubiquitin-protein ligase RMD5

1

0

High-throughput

0.458

High

393049

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

481697

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.445

High

524596

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.445

High

527210

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.445

High

545605

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

579757

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.445

High

670938

SIS1
Protein SIS1

1

1

High-throughput

0.445

High

727190

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

742002

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

742900

HSP79
Heat shock protein homolog SSE2

1

8

High-throughput

0.445

High

819296

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

824492

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.445

High

707677

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

365125

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

386796

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

394742

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

453696

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

486494

TBA3
Tubulin alpha-3 chain

1

0

High-throughput

0.426

High

592380

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

836796

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

912414

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

917100

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

917093

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

917097

SPC24
Kinetochore protein SPC24

1

0

Small-scale

0.251

Low

382227

H4
Histone H4

1

0

High-throughput

0.249

Low

739699

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

792876

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.249

Low

866233

IML1
Vacuolar membrane-associated protein IML1

1

0

High-throughput

0.249

Low

917094

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low

575482

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

849534

GCN20
Protein GCN20

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025